Results 141 to 150 of about 873,934 (176)

Trans-chalcone: a novel small molecule inhibitor of mammalian alpha-amylase

Molecular Biology Reports, 2010
Trans-chalcone (1,3-diphenyl-2-propen-1-one), a biphenolic core structure of flavonoids precursor was tested for inhibitory activity toward alpha-amylase. Porcine pancreatic alpha-amylase was observed to be effectively inhibited by this compound, which showed competitive behavior with a K(i) of 48 μM. Soluble starch (the natural substrate of the enzyme)
Bagher Larijani, Parichehreh Yaghmaei, Kazem Parivar   +2 more
exaly   +3 more sources

Trans-Chalcone prevents VEGF expression and retinal neovascularization in the ischemic retina

Experimental Eye Research, 2011
Retinal neovascularization (RNV) is a critical pathological event and a major cause of blindness. Vascular inflammation and oxidative stress have been shown to play a key role in the induction and progression of RNV. Trans-Chalcone-derived flavonoids have been previously shown to be negative modulators of oxidative stress and inflammatory responses as ...
Mónica Varano, Manuela Bartoli
exaly   +3 more sources

Ultrasound-assisted Antisolvent Crystallisation of trans-chalcone

Antisolvent crystallisation of trans-chalcone was investigated using ethanol as the solvent and water as the antisolvent under both silent and ultrasound-assisted conditions. Solubility, metastable zone width, crystal yield, crystal structure, morphology, and particle size and shape distribution were evaluated.
Subramaniam Chidambaranathapillai, Subhrajit Swain, Vivek Ranade, Tom Van Gerven, Maela Manzoli, Giancarlo Cravotto   +5 more
openaire   +2 more sources

Phytotoxic Potential of Trans-chalcone on Crop Plants and Model Species

Journal of Plant Growth Regulation, 2013
Peer ...
Adela M Sánchez-Moreiras, Manuel Joaquín Reigosa Roger, Elisa Grana   +2 more
exaly   +3 more sources

Polycaprolactone/epoxide-functionalized silica composite microparticles for long-term controlled release of trans-chalcone

Journal of Polymer Engineering, 2022
Abstract In this study, controlled release of trans-chalcone was achieved by using a polycaprolactone-based hybrid system as the drug carrier material. Encapsulation efficiency was obtained in the range of 70–75% for various formulations and in vitro release studies, conducted at 37 °C and pH 7.4, revealed slow profile reaching 60 ...
Yasemin Kaptan
exaly   +2 more sources

Trans-Chalcone Plus Baicalein Synergistically Reduce Intracellular Amyloid Beta (Aβ42) and Protect from Aβ42 Induced Oxidative Damage in Yeast Models of Alzheimer’s Disease

International Journal of Molecular Sciences, 2021
Finding an effective therapeutic to prevent or cure AD has been difficult due to the complexity of the brain and limited experimental models. This study utilized unmodified and genetically modified Saccharomyces cerevisiae as model organisms to find ...
Ian Macreadie, Paul Ramsland, Sudip Dhakal   +2 more
exaly   +2 more sources

Trans-chalcone attenuate arsenic-induced toxicity in 3T3 embryonic fibroblast cells; An in vitro and in silico study

Journal of Molecular Structure
UNSAL, VELID/0000-0003-1415-0563This study investigated the curative role of trans-chalcone, a flanovide, against arsenic toxicity using in vitro and computer-based analyses. MTT and LDH methods were used to assess the cytotoxicity and viability of cells,
ReŞit Yıldız, Mustafa Cicek, Ergul Belge Kurutas   +2 more
exaly   +2 more sources

Clay-catalysed solventless synthesis of trans-chalcones

Green Chemistry, 2001
trans-Chalcones have been obtained in good yields and selectivities following an environmentally friendly methodology by using montmorillonite KSF as a reusable heterogeneous catalyst.
Ballini R., Bosica G., Maggi R., Ricciutelli M., Righi P., Sartori G., Sartorio R.   +6 more
openaire   +3 more sources

Two Nitro-α-methoxy-trans-chalcones

Acta Crystallographica Section C Crystal Structure Communications, 1996
The crystal structures of 2-methoxy-3-(3-nitrophenyl)-1-phenylprop-2-en-1-one, C16H13NO4, (Ia), and 2-methoxy-3-(2-nitrophenyl)-1-phenylprop-2-en-1-one, C16H13NO4, (Ib), are reported. These two molecules are constitutional isomers differing in the position of the nitro group attached to one of the phenyl rings.
M. Bolte, G. Schütz, H. J. Bader
openaire   +1 more source

Circular dichroism spectra of trans-chalcone epoxides

Tetrahedron: Asymmetry, 2007
Abstract The electronic absorption and CD spectra of (−)- trans -chalcone epoxide and its derivatives with methyl and alkoxy substituents at the ortho -positions of the aromatic rings have been measured. The spectra have been assigned with help of the energies, oscillatory strengths, and rotatory strengths of the singlet transitions obtained from ...
Krisztina Pál, Mihály Kállay, Miklós Kubinyi, Péter Bakó, Attila Makó   +4 more
openaire   +1 more source