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Integrative metabolomic and transcriptomic profiling deciphers flavonoid biosynthesis of bulbs in Lilium brownii var. Viridulum. [PDF]
Sci RepWang PT +5 more
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Acta Tropica, 2006 The present study was designed to investigate a new administration model and the antileishmanial activity of a semi-synthetic chalcone, benzylideneacetophenone (trans-chalcone). The antileishmanial activity of this product was first tested in vitro against promastigotes of L. braziliensis, L. tropica, L. infantum and L. amazonensis.
Jose, Piñero +8 more
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Trans-chalcone: a novel small molecule inhibitor of mammalian alpha-amylase
Molecular Biology Reports, 2010Trans-chalcone (1,3-diphenyl-2-propen-1-one), a biphenolic core structure of flavonoids precursor was tested for inhibitory activity toward alpha-amylase. Porcine pancreatic alpha-amylase was observed to be effectively inhibited by this compound, which showed competitive behavior with a K(i) of 48 μM. Soluble starch (the natural substrate of the enzyme)
Azadeh Ebrahim-Habibi +2 more
exaly +3 more sources
Trans-Chalcone prevents VEGF expression and retinal neovascularization in the ischemic retina
Experimental Eye Research, 2011Retinal neovascularization (RNV) is a critical pathological event and a major cause of blindness. Vascular inflammation and oxidative stress have been shown to play a key role in the induction and progression of RNV. Trans-Chalcone-derived flavonoids have been previously shown to be negative modulators of oxidative stress and inflammatory responses as ...
Anna Lisa Montemari +2 more
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International Journal of Molecular Sciences, 2021 Finding an effective therapeutic to prevent or cure AD has been difficult due to the complexity of the brain and limited experimental models. This study utilized unmodified and genetically modified Saccharomyces cerevisiae as model organisms to find ...
Sudip Dhakal +2 more
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Journal of Molecular StructureUNSAL, VELID/0000-0003-1415-0563This study investigated the curative role of trans-chalcone, a flanovide, against arsenic toxicity using in vitro and computer-based analyses. MTT and LDH methods were used to assess the cytotoxicity and viability of cells,
Velid Unsal +2 more
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Nutrition and Food Science, 2021 Purpose: The debate on the metabolic effects of high fructose corn syrup (HFCS) continues. The deterioration of endoplasmic reticulum (ER) homeostasis is called ER stress.
Velid Unsal +2 more
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Clay-catalysed solventless synthesis of trans-chalcones
Green Chemistry, 2001trans-Chalcones have been obtained in good yields and selectivities following an environmentally friendly methodology by using montmorillonite KSF as a reusable heterogeneous catalyst.
Ballini R. +6 more
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Two Nitro-α-methoxy-trans-chalcones
Acta Crystallographica Section C Crystal Structure Communications, 1996The crystal structures of 2-methoxy-3-(3-nitrophenyl)-1-phenylprop-2-en-1-one, C16H13NO4, (Ia), and 2-methoxy-3-(2-nitrophenyl)-1-phenylprop-2-en-1-one, C16H13NO4, (Ib), are reported. These two molecules are constitutional isomers differing in the position of the nitro group attached to one of the phenyl rings.
M. Bolte, G. Schütz, H. J. Bader
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Circular dichroism spectra of trans-chalcone epoxides
Tetrahedron: Asymmetry, 2007Abstract The electronic absorption and CD spectra of (−)- trans -chalcone epoxide and its derivatives with methyl and alkoxy substituents at the ortho -positions of the aromatic rings have been measured. The spectra have been assigned with help of the energies, oscillatory strengths, and rotatory strengths of the singlet transitions obtained from ...
Krisztina Pál +4 more
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