Results 151 to 160 of about 736,450 (179)

Chemical sensing of chalcones by voltammetry: trans-Chalcone, cardamonin and xanthohumol

Electrochimica Acta, 2013
Abstract Xanthohumol (XN) and cardamonin (CD) belong to the chemical class of chalcones which are phenolic compounds of large interest due to their health promoting properties. In the present work, their electrochemical behavior on a hanging mercury drop electrode (HMDE) is compared to trans -chalcone by means of cyclic voltammetry (CV).
Tavares, E.M., Carvalho, A.M., Gonçalves, Luis M., Valente, I.M., Moreira, M.M., Guido, L.F., Rodrigues, J.A., Doneux, Thomas, Barros, Aquiles   +8 more
openaire   +2 more sources

Electronic absorption spectra of heterocyclic analogs of trans-chalcone

Chemistry of Heterocyclic Compounds, 1977
Thiophene, furan, and pyrrole analogs of trans-chalcone have UV spectra consisting of bands belonging to the spectra of the corresponding 2-acetylhetaryls and 2-hetarylideneacetones that are shifted bathochromically as a result of mutual perturbation of these two crossconjugated fragments.
M. Reinkhardt, A. A. Sukhorukov, A. Raushal', V. F. Lavrushin   +3 more
openaire   +1 more source

Abstract 4654: Antitumorigenic activity of trans-chalcone in osteosarcoma

Cancer Research, 2015
Abstract Background and Aims: Osteosarcoma is the most common bone cancer, and it affects mostly teenagers and children. Although the emergence of multidrug therapies has improved available treatments for osteosarcoma, approximately 30% of patients will still develop metastasis.
Gabriel da Silva, Mozart Marins, Ana Lúcia Fachin, Seung J. Baek   +3 more
openaire   +1 more source

Development of trans-Chalcone loaded pectin/casein biodegradable microcapsules: Efficacy improvement in the management of experimental colitis

International Journal of Pharmaceutics, 2023
Improved therapies for inflammatory bowel diseases are sorely needed. Novel therapeutic agents and the development of controlled release systems for targeted tissue delivery are interesting approaches to overcome these barriers. We investigated the activity of trans-chalcone (T) in acetic acid-induced colitis in mice and developed, characterized, and ...
Carla F.S. Guazelli, Victor Fattori, Barbara B. Colombo, Isabela S. Ludwig, Laisa G. Vicente, Renata M. Martinez, Sandra R. Georgetti, Alexandre Urbano, Rubia Casagrande, Marcela M. Baracat, Waldiceu A. Verri   +10 more
openaire   +2 more sources

Polycaprolactone/epoxide-functionalized silica composite microparticles for long-term controlled release of trans-chalcone

Journal of Polymer Engineering, 2022
Abstract In this study, controlled release of trans-chalcone was achieved by using a polycaprolactone-based hybrid system as the drug carrier material. Encapsulation efficiency was obtained in the range of 70–75% for various formulations and in vitro release studies, conducted at 37 °C and pH 7.4, revealed slow profile reaching 60 ...
Yasemin Kaptan, Yüksel Güvenilir
openaire   +1 more source

Solubility enhancement of trans-chalcone using lipid carriers and supercritical CO2 processing

The Journal of Supercritical Fluids, 2009
Abstract This work studies the possibility of enhancing the solubility of 1,3-diphenyl-2-propenone, the core structure of chalcones, through lipidic formulations under supercritical CO 2 processing. Microparticles of chalcone, alone and with lipid carriers, were produced by PGSS ® , a method which involves the quick depressurization of a gas ...
A.R. Sampaio de Sousa, Rodrigo Silva, Feng H. Tay, Ana Luísa Simplício, Sergei G. Kazarian, Catarina M.M. Duarte   +5 more
openaire   +1 more source

trans-Chalcone modulates Leishmania amazonensis infection in vitro by Nrf2 overexpression affecting iron availability

European Journal of Pharmacology, 2019
Leishmania parasites infect macrophages causing a wide spectrum of human diseases encompassing from cutaneous to visceral forms. The drugs currently used in leishmaniasis treatment are highly toxic and associated with acquired resistance. Seeking novel therapeutic targets, we conducted a comprehensive in vitro study to investigate the action of trans ...
Milena Menegazzo, Miranda-Sapla, Fernanda, Tomiotto-Pellissier, João Paulo, Assolini, Amanda Cristina Machado, Carloto, Bruna Taciane da Silva, Bortoleti, Manoela Daiele, Gonçalves, Eliandro Reis, Tavares, Jean Henrique da Silva, Rodrigues, Andréa Name Colado, Simão, Lucy Megumi, Yamauchi, Celso Vataru, Nakamura, Waldiceu A, Verri, Idessania Nazareth, Costa, Ivete, Conchon-Costa, Wander Rogerio, Pavanelli   +14 more
openaire   +2 more sources

Hiding and unveiling trans-chalcone in a constrained derivative of 4′,7-dihydroxyflavylium in water: a versatile photochromic system

Organic & Biomolecular Chemistry, 2017
Rigidifying 4′,7-dihydroxyflavylium prevents the formation of trans-chalcone (Ct). The addition of CTAB micelles unveils Ct enabling photochromism. Disrupting the micelles with α-cyclodextrin returns the system to its initial state.
Márcia, Pessêgo, Sandra, Gago, Nuno, Basílio, César A T, Laia, A, Jorge Parola, João C, Lima, Fernando, Pina   +6 more
openaire   +2 more sources

Anti-cancer activity of trans-chalcone in osteosarcoma: Involvement of Sp1 and p53.

Molecular carcinogenesis, 2017
Osteosarcoma is the most common bone cancer. Although the emergence of multidrug therapies has improved available treatments for osteosarcoma, approximately 30% of patients will still develop metastasis. Currently, much anticancer therapy uses drugs that affect oncogenes/tumor suppressor genes, such as p53 (up-regulation) and Sp1 (down-regulation ...
Gabriel, Silva, Mozart, Marins, Ana Lúcia, Fachin, Seong-Ho, Lee, Seung Joon, Baek   +4 more
openaire   +1 more source

Kinetics and mechanism of reactions of cis- and trans-chalcones with amines

Journal of the American Chemical Society, 1969
F M, Menger, J H, Smith
openaire   +2 more sources