Results 191 to 200 of about 6,216 (203)

Solubility enhancement of trans-chalcone using lipid carriers and supercritical CO2 processing

The Journal of Supercritical Fluids, 2009
Abstract This work studies the possibility of enhancing the solubility of 1,3-diphenyl-2-propenone, the core structure of chalcones, through lipidic formulations under supercritical CO 2 processing. Microparticles of chalcone, alone and with lipid carriers, were produced by PGSS ® , a method which involves the quick depressurization of a gas ...
A.R. Sampaio de Sousa, Rodrigo Silva, Feng H. Tay, Ana Luísa Simplício, Sergei G. Kazarian, Catarina M.M. Duarte   +5 more
openaire   +1 more source

New administration model of trans-chalcone biodegradable polymers for the treatment of experimental leishmaniasis

Acta Tropica, 2006
The present study was designed to investigate a new administration model and the antileishmanial activity of a semi-synthetic chalcone, benzylideneacetophenone (trans-chalcone). The antileishmanial activity of this product was first tested in vitro against promastigotes of L. braziliensis, L. tropica, L. infantum and L. amazonensis.
Jose, Piñero, Rosane M, Temporal, Antonio J, Silva-Gonçalves, I A, Jiménez, Isabel L, Bazzocchi, Alexis, Oliva, Antonio, Perera, Leonor L, Leon, Basilio, Valladares   +8 more
openaire   +2 more sources

trans-Chalcone modulates Leishmania amazonensis infection in vitro by Nrf2 overexpression affecting iron availability

European Journal of Pharmacology, 2019
Leishmania parasites infect macrophages causing a wide spectrum of human diseases encompassing from cutaneous to visceral forms. The drugs currently used in leishmaniasis treatment are highly toxic and associated with acquired resistance. Seeking novel therapeutic targets, we conducted a comprehensive in vitro study to investigate the action of trans ...
Milena Menegazzo, Miranda-Sapla, Fernanda, Tomiotto-Pellissier, João Paulo, Assolini, Amanda Cristina Machado, Carloto, Bruna Taciane da Silva, Bortoleti, Manoela Daiele, Gonçalves, Eliandro Reis, Tavares, Jean Henrique da Silva, Rodrigues, Andréa Name Colado, Simão, Lucy Megumi, Yamauchi, Celso Vataru, Nakamura, Waldiceu A, Verri, Idessania Nazareth, Costa, Ivete, Conchon-Costa, Wander Rogerio, Pavanelli   +14 more
openaire   +2 more sources

ChemInform Abstract: Chalcone Aziridines. Part 3. Reaction of trans‐Chalcone Aziridines with Isocyanates, Isothiocyanates and HSCN.

ChemInform, 1987
AbstractThe reaction of the aziridines (I) with the isocyanate (II) or with the isothiocyanates (VIII) yields the 1‐phenylcarbamoyl aziridines (III) or the thiazolines (IX).
F. G. WEBER, H. LIEPERT, H. + KOEPPEL
openaire   +1 more source

Hiding and unveiling trans-chalcone in a constrained derivative of 4′,7-dihydroxyflavylium in water: a versatile photochromic system

Organic & Biomolecular Chemistry, 2017
Rigidifying 4′,7-dihydroxyflavylium prevents the formation of trans-chalcone (Ct). The addition of CTAB micelles unveils Ct enabling photochromism. Disrupting the micelles with α-cyclodextrin returns the system to its initial state.
Márcia, Pessêgo, Sandra, Gago, Nuno, Basílio, César A T, Laia, A, Jorge Parola, João C, Lima, Fernando, Pina   +6 more
openaire   +2 more sources

Anti-cancer activity of trans-chalcone in osteosarcoma: Involvement of Sp1 and p53.

Molecular carcinogenesis, 2017
Osteosarcoma is the most common bone cancer. Although the emergence of multidrug therapies has improved available treatments for osteosarcoma, approximately 30% of patients will still develop metastasis. Currently, much anticancer therapy uses drugs that affect oncogenes/tumor suppressor genes, such as p53 (up-regulation) and Sp1 (down-regulation ...
Gabriel, Silva, Mozart, Marins, Ana Lúcia, Fachin, Seong-Ho, Lee, Seung Joon, Baek   +4 more
openaire   +1 more source

ChemInform Abstract: Chalcone Aziridines. Part 4. Comparison of Spectroscopical and Mass Spectrometrical Behavior of trans‐Chalcone Aziridines and trans‐Chalcone Epoxides

ChemInform, 1989
F. G. WEBER, H. LIEPERT, R. RADEGLIA, H. + KOEPPEL   +3 more
openaire   +1 more source

Kinetics and mechanism of reactions of cis- and trans-chalcones with amines

Journal of the American Chemical Society, 1969
F M, Menger, J H, Smith
openaire   +2 more sources

ChemInform Abstract: ELECTRON ABSORPTION SPECTRA OF HETEROCYCLIC ANALOGS OF TRANS‐CHALCONE

Chemischer Informationsdienst, 1978
M. REINKHARDT, A. A. SUKHORUKOV, A. RAUSHAL', V. F. LAVRUSHIN   +3 more
openaire   +1 more source

Localizability of ?-electronic transitions in spectra of trans-chalcone and their classification

Theoretical and Experimental Chemistry, 1977
A. A. Sukhorukov, V. �. Umanskii, B. A. Zadorozhnyi, V. F. Lavrushin   +3 more
openaire   +1 more source