Results 141 to 150 of about 85,659 (234)
Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.GBM‐derived EVs transfer NCL to endothelial cells to facilitate BTB formation. AS1411‐based PROTACs exploit NCL‐dependent transcytosis to selectively cross the BTB and enter GBM. By recruiting the NCL‐MDM2 complex, these PROTACs induce the targeted degradation of POIs (VEGFR2/EGFR) to suppress tumor growth.
Hongzhen Chen +7 more
wiley +1 more source
The Open Reading Frame 7b of the SARS‐CoV‐2 Disperse Trans‐Golgi and Activate the NLRP3 Inflammasome
Journal of Medical Virology, Volume 98, Issue 4, April 2026.ABSTRACT Inflammasomes orchestrate the inflammatory response against bacterial and viral infections, thereby initiating the synthesis of pro‐inflammatory cytokines, mainly IL‐1β and IL‐18. SARS‐CoV‐2 infection induces an inflammatory response mediated by the activation of NLRP1 and NLRP3 inflammasomes.
Julio García‐Villalba +4 more
wiley +1 more source
Toxic mechanisms of amyloid oligomers and therapeutic strategies
Protein Science, Volume 35, Issue 4, April 2026.Abstract Amyloid oligomers are increasingly recognized as the major toxic contributors across protein‐misfolding disorders. In this review, we cover mechanistic evidence showing how these transient and structurally heterogeneous oligomers disrupt cellular homeostasis by: (i) permeabilizing lipid membranes and forming ion‐conducting pores; (ii ...
Magdalena I. Ivanova +2 more
wiley +1 more source
FASEB BioAdvances, Volume 8, Issue 4, April 2026.This graphical abstract illustrates that extracellular vesicles (EVs) are preferentially taken up by pulmonary artery endothelial cells in pulmonary arterial hypertension (PAH). Uptake is enhanced in diseased vessels and occurs exclusively in endothelium, not smooth muscle.
Aritra Bhadra +4 more
wiley +1 more source
Correction to: RAB GTPases and SNAREs at the trans-Golgi network in plants. [PDF]
J Plant Res, 2022 Ito E, Uemura T.
europepmc +1 more source
Engineering Yeast Extracellular Vesicle Biogenesis Through Rewiring Membrane Trafficking Pathways
Microbial Biotechnology, Volume 19, Issue 4, April 2026.Engineered Saccharomyces cerevisiae reveals how cell wall remodelling and membrane trafficking coordinate extracellular vesicle biogenesis. Interferon overexpression and chs3 deletion enhance EV secretion and reshape SNARE‐, Rab‐ and ESCRT‐associated pathways, establishing yeast as a versatile platform for EV engineering and therapeutic cargo loading ...
Yueyan Li +11 more
wiley +1 more source
New Phytologist, Volume 250, Issue 2, Page 799-804, April 2026.Summary Plant immunity is complex, and studies of leaf epidermal cells attacked by powdery mildew fungi have been instrumental in revealing how it relies on plant endomembrane trafficking. Immunity against these biotrophic fungi is manifested as cell wall deposits (‘papillae’) and the hypersensitive reaction (HR), both involving plant endomembrane ...
Hans Thordal‐Christensen +3 more
wiley +1 more source
Molecular Mechanisms of Secreting Vesicle Biogenesis and Secretion in Chronic Degenerative Diseases [PDF]
, 2012 Regulated trafficking and secretion of insulin by the β cell of the endocrine pancreas is critical to maintain our body energy homeostasis. Disruption of these processes typically leads to hyperglycemia and the complications of diabetes.
Qiao, Xinxian
core
The FASEB Journal, Volume 40, Issue 6, 31 March 2026.ORMDL proteins in the endoplasmic reticulum (ER) negatively regulate serine palmitoyltransferase (SPT) activity in response to the rate of de novo sphingolipid synthesis. Disruption of ceramide homeostasis by myriocin or fumonisin B1 (FB1) appears to destabilize the ORMDL‐SPT complex, leading to ORMDL degradation as a feedback mechanism.
Michal Mrkacek +7 more
wiley +1 more source
IKKβ primes inflammasome formation by recruiting NLRP3 to the trans-Golgi network. [PDF]
Immunity, 2022 Schmacke NA +19 more
europepmc +1 more source