Results 11 to 20 of about 85,659 (234)

Transport Vesicle Tethering at the Trans Golgi Network: Coiled Coil Proteins in Action [PDF]

Frontiers in Cell and Developmental Biology, 2016
The Golgi complex is decorated with so-called Golgin proteins that share a common feature: a large proportion of their amino acid sequences are predicted to form coiled-coil structures.
Pak-yan P. Cheung, Suzanne R. Pfeffer
core   +4 more sources

Golgi-associated retrograde protein (GARP) complex-dependent endosomes to trans Golgi network retrograde trafficking is controlled by Rab4b. [PDF]

Cell Mol Biol Lett
Background The trafficking of cargoes from endosomes to the trans-Golgi network requires numerous sequential and coordinated steps. Cargoes are sorted into endosomal-derived carriers that are transported, tethered, and fused to the trans-Golgi network ...
Gilleron J, Chafik A, Lacas-Gervais S, Tanti JF, Cormont M.   +4 more
europepmc   +2 more sources

LDL transcytosis passes through the trans-Golgi network and requires Rab10. [PDF]

J Lipid Res
Atherosclerosis begins with the subendothelial retention of LDLs from the circulation. While LDL transcytosis across the endothelium is mediated by scavenger receptor class B type I and activin-like kinase receptor 1 and is usually independent of LDL ...
Winnie Ho TW, Wang C, Lee WL.
europepmc   +2 more sources

Nanoscopical Analysis Reveals an Orderly Arrangement of the Presynaptic Scaffold Protein Bassoon at the Golgi-Apparatus

Frontiers in Molecular Neuroscience, 2021
Bassoon is a core scaffold protein of the presynaptic active zone. In brain synapses, the C-terminus of Bassoon is oriented toward the plasma membrane and its N-terminus is oriented toward synaptic vesicles.
Tina Ghelani, Carolina Montenegro-Venegas, Carolina Montenegro-Venegas, Carolina Montenegro-Venegas, Anna Fejtova, Anna Fejtova, Anna Fejtova, Thomas Dresbach   +7 more
doaj   +1 more source

IFT20 Mediates the Transport of Cell Migration Regulators From the Trans-Golgi Network to the Plasma Membrane in Breast Cancer Cells. [PDF]

Front Cell Dev Biol, 2021
IFT20 is a subunit of the intraflagellar transport (IFT) system essential for the formation and function of cilia. Besides predominant research in the cilia field, some IFT subunits perform extraciliary roles in non-ciliated cancer cells.
Yang H, Zhang F, Long H, Lin Y, Liao J, Xia H, Huang K.   +6 more
europepmc   +2 more sources

Sphingolipids mediate polar sorting of PIN2 through phosphoinositide consumption at the trans-Golgi network. [PDF]

Nat Commun, 2021
Lipid composition impacts the function of cellular membranes. Here the authors show that a reduction in sphingolipid acyl-chain length promotes phosphoinositide consumption by phospholipase C at the Arabidopsis trans-Golgi network which in turn regulates
Ito Y, Esnay N, Platre MP, Wattelet-Boyer V, Noack LC, Fougère L, Menzel W, Claverol S, Fouillen L, Moreau P, Jaillais Y, Boutté Y.   +11 more
europepmc   +2 more sources

Cargo sorting zones in the trans-Golgi network visualized by super-resolution confocal live imaging microscopy in plants. [PDF]

Nat Commun, 2021
The trans-Golgi network (TGN) serves as a platform to sort and transport proteins to their final destinations. Here the authors show that the TGN of Arabidopsis consists of spatially and temporally distinct subregions and propose that these zones may ...
Shimizu Y, Takagi J, Ito E, Ito Y, Ebine K, Komatsu Y, Goto Y, Sato M, Toyooka K, Ueda T, Kurokawa K, Uemura T, Nakano A.   +12 more
europepmc   +2 more sources

The Golgi Apparatus and its Next-Door Neighbors

Frontiers in Cell and Developmental Biology, 2022
The Golgi apparatus represents a central compartment of membrane traffic. Its apparent architecture, however, differs considerably among species, from unstacked and scattered cisternae in the budding yeast Saccharomyces cerevisiae to beautiful ministacks
Akihiko Nakano
doaj   +1 more source

Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion

Hepatology, EarlyView., 2022
The role of SMLR1 in lipid metabolism (high fat + cholesterol diet in mice) Abstract Background and Aims The assembly and secretion of VLDL from the liver, a pathway that affects hepatic and plasma lipids, remains incompletely understood. We set out to identify players in the VLDL biogenesis pathway by identifying genes that are co‐expressed with the ...
Willemien van Zwol, Antoine Rimbert, Justina C. Wolters, Marieke Smit, Vincent W. Bloks, Niels J. Kloosterhuis, Nicolette C. A. Huijkman, Mirjam H. Koster, Umesh Tharehalli, Simon M. de Neck, Colin Bournez, Marceline M. Fuh, Jeroen Kuipers, Sujith Rajan, Alain de Bruin, Henry N. Ginsberg, Gerard J. P. van Westen, M. Mahmood Hussain, Ludger Scheja, Joerg Heeren, Philip Zimmerman, Bart van de Sluis, Jan Albert Kuivenhoven   +22 more
wiley   +1 more source

Sphingolipid metabolic flow controls phosphoinositide turnover at the trans Golgi network [PDF]

, 2017
Sphingolipids are membrane lipids, which are globally required for eukaryotic life. Sphingolipid composition varies among endomembranes with pre- and post-Golgi compartments being poor and rich in sphingolipids, respectively.
Alberto Luini, Angelika Hausser, Chiara Luberto, Domenico Russo, Elina Ikonen, Felix Campelo, Gabriele Turacchio, Giovanni D'Angelo, Howard Riezman, Isabelle Riezman, Josse Galen, Lucia Sticco, Maarit Hölttä‐Vuori, Marinella Pirozzi, Nina A Dathan, Riccardo Rizzo, Seetharaman Parashuraman, Serena Capasso, Vivek Malhotra, Wang E   +19 more
core   +3 more sources