Results 41 to 50 of about 85,659 (234)

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

HID-1 controls formation of large dense core vesicles by influencing cargo sorting and trans-Golgi network acidification [PDF]

, 2017
Large dense core vesicles (LDCVs) mediate the regulated release of neuropeptides and peptide hormones. They form at the trans-Golgi network (TGN), where their soluble content aggregates to form a dense core, but the mechanisms controlling biogenesis are ...
Asensio, Cedric S, Burns, Christian, Chen, Lan, de Leeuw, Noah F, Fitzpatrick, James A. J., Hosford, Bethany, Hummer, Blake H, Joens, Matthew S   +7 more
core   +2 more sources

Traffic from the endosome towards trans-Golgi network

European Journal of Cell Biology, 2017
Retrograde passage of a transport carrier entails cargo sorting at the endosome, generation of a cargo-laden carrier and its movement along cytoskeletal tracks towards trans-Golgi network (TGN), tethering at the TGN, and fusion with the Golgi membrane.
Uma, Saimani, Kyoungtae, Kim
openaire   +2 more sources

Compartmentation of the Golgi complex: brefeldin-A distinguishes trans-Golgi cisternae from the trans-Golgi network. [PDF]

The Journal of cell biology, 1990
The Golgi complex is composed of at least four distinct compartments, termed the cis-, medial, and trans-Golgi cisternae and the trans-Golgi network (TGN). It has recently been reported that the organization of the Golgi complex is disrupted in cells treated with the fungal metabolite, brefeldin-A.
N W, Chege, S R, Pfeffer
openaire   +2 more sources

Internalized TSH receptors en route to the TGN induce local Gs-protein signaling and gene transcription

Nature Communications, 2017
Recent investigations suggest that G-protein-coupled receptors (GPCRs) can signal during intracellular trafficking. Here the authors use fluorescence microscopy approaches to directly visualize and investigate functional consequences of GPCR-mediated ...
Amod Godbole, Sandra Lyga, Martin J. Lohse, Davide Calebiro   +3 more
doaj   +1 more source

Subcellular localization of microsomal triglyceride transfer protein

Journal of Lipid Research, 2003
Microsomal triglyceride transfer protein (MTP) is essential for the assembly of apolipoprotein B-containing lipoproteins. Within the endoplasmic reticulum, it transfers lipid from the membrane to the forming lipoprotein.
Larry L. Swift, Mei-Ying Zhu, Bharati Kakkad, Aneta Jovanovska, M. Diana Neely, Klara Valyi-Nagy, Richard L. Roberts, David E. Ong, W. Gray Jerome   +8 more
doaj   +1 more source

TGNap1 is required for microtubule-dependent homeostasis of a subpopulation of the plant trans-Golgi network. [PDF]

Nat Commun, 2018
The plant trans-Golgi network comprises functionally distinct subcompartments. Here Renna et al. show that the TGNap1 protein acts in microtubule-dependent biogenesis, tracking and function of a TGN subset, highlighting diversification within the plant ...
Renna L, Stefano G, Slabaugh E, Wormsbaecher C, Sulpizio A, Zienkiewicz K, Brandizzi F.   +6 more
europepmc   +2 more sources

Golgi retention and oncogenic KIT signaling via PLCγ2-PKD2-PI4KIIIβ activation in gastrointestinal stromal tumor cells

Cell Reports, 2023
Summary: Most gastrointestinal stromal tumors (GISTs) develop due to gain-of-function mutations in the tyrosine kinase gene, KIT. We recently showed that mutant KIT mislocalizes to the Golgi area and initiates uncontrolled signaling.
Yuuki Obata, Kazuo Kurokawa, Takuro Tojima, Miyuki Natsume, Isamu Shiina, Tsuyoshi Takahashi, Ryo Abe, Akihiko Nakano, Toshirou Nishida   +8 more
doaj   +1 more source

The Golgi Apparatus: Morphology and Function with Recent Facts

Bezmiâlem Science, 2019
At the center of the secretory pathway, the Golgi complex ensures correct processing and sorting of cargos towards their final destination sites which are the cytoplasm, plasma membrane, and endosome-lysosome system.
Mukaddes Eşrefoğlu
doaj   +1 more source

Posttranslational modifications of GLUT4 affect its subcellular localization and translocation [PDF]

, 2013
The facilitative glucose transporter type 4 (GLUT4) is expressed in adipose and muscle and plays a vital role in whole body glucose homeostasis. In the absence of insulin, only ~1% of cellular GLUT4 is present at the plasma membrane, with the vast ...
Bayer, Begum, Birnbaum, Bogan, Bogan, Bogan, Bryant, Cassie Welburn, Chang, Fujita, Garvey, Gill, Giorgino, Govers, Grasbon-Frodl, Gwyn Gould, Haga, Hardy, Herrmann, Hicke, Huang, Ing, James, James, Jessica Sadler, Jeyaraj, Karylowski, Kupriyanova, Lamb, Lau, Lawrence, Lawrence, Leto, Li, Liu, Livingstone, Mahajan, Marsh, Marshall, Marshall, Martin, Matunis, McCormick, Muller, Nia Bryant, Perera, Pessin, Pilch, Piper, Ren, Reusch, Saltiel, Semiz, Shi, Shi, Stöckli, Toh, Urbe, Vannucci, Varki, Watson, Williams, Yang, Yu, Zaarour   +64 more
core   +3 more sources