Results 51 to 60 of about 85,659 (234)

The WDR11 complex facilitates the tethering of AP-1-derived vesicles

Nature Communications, 2018
Trafficking from endosomes to the trans-Golgi network requires recognition of vesicle tethers during membrane docking. Here, the authors identify a complex localised to AP-1 generated vesicles containing WDR11, C17orf75 and FAM91A, which together with ...
Paloma Navarro Negredo, James R. Edgar, Paul T. Manna, Robin Antrobus, Margaret S. Robinson   +4 more
doaj   +1 more source

Rab6A as a Pan-Astrocytic Marker in Mouse and Human Brain, and Comparison with Other Glial Markers (GFAP, GS, Aldh1L1, SOX9)

Cells, 2021
Astrocytes contribute to many higher brain functions. A key mechanism in glia-to-neuron signalling is vesicular exocytosis; however, the identity of exocytosis organelles remains a matter of debate.
Linda Melzer, Thomas M. Freiman, Amin Derouiche   +2 more
doaj   +1 more source

Golgicide A Reveals Essential Roles for GBF1 in Golgi Assembly and Function [PDF]

, 2013
ADP-ribosylation factor 1 (Arf1) plays a critical role in regulating secretory traffic and membrane transport within the Golgi of eukaryotic cells. Arf1 is activated by guanine nucleotide exchange factors (ArfGEFs) which confer spatial and temporal ...
Bursulaya, Badry, Chang, Jae Won, Gray, Nathanael S., Haslam, David B., Li, Jinmei, Saenz, Jose B., Sun, William J.   +6 more
core   +1 more source

Multiple activities of Arl1 GTPase in the trans-Golgi network [PDF]

Journal of Cell Science, 2017
ABSTRACT ADP-ribosylation factors (Arfs) and ADP-ribosylation factor-like proteins (Arls) are highly conserved small GTPases that function as main regulators of vesicular trafficking and cytoskeletal reorganization. Arl1, the first identified member of the large Arl family, is an important regulator of Golgi complex structure and ...
Chia-Jung Yu, Fang-Jen S. Lee
openaire   +2 more sources

SCYL2 Genes Are Involved in Clathrin-Mediated Vesicle Trafficking and Essential for Plant Growth [PDF]

, 2018
Protein transport between organelles is an essential process in all eukaryotic cells and is mediated by the regulation of processes such as vesicle formation, transport, docking, and fusion.
Hwang, Inhwan, Jung, Ji-Yul, Lee, Don-Wook, Ryu, Stephen Beungtae, Schachtman, Daniel P.   +4 more
core   +1 more source

Rab6a/a' are important Golgi regulators of pro-inflammatory TNF secretion in macrophages. [PDF]

PLoS ONE, 2013
Lipopolysaccharide (LPS)-activated macrophages secrete pro-inflammatory cytokines, including tumor necrosis factor (TNF) to elicit innate immune responses.
Massimo Micaroni, Amanda C Stanley, Tatiana Khromykh, Juliana Venturato, Colin X F Wong, Jet P Lim, Brad J Marsh, Brian Storrie, Paul A Gleeson, Jennifer L Stow   +9 more
doaj   +1 more source

Protein trafficking through the endosomal system prepares intracellular parasites for a home invasion [PDF]

, 2013
Toxoplasma (toxoplasmosis) and Plasmodium (malaria) use unique secretory organelles for migration, cell invasion, manipulation of host cell functions, and cell egress. In particular, the apical secretory micronemes and rhoptries of apicomplexan parasites
A Fomovska, AE Topolska, B Lige, B Shen, BF Kafsack, BJ Luft, C Lord, CA Hunter, Chetan E. Chitnis, Christian Slomianny, CY He, D Richard, DL Alexander, F Parussini, H El Hajj, HC Hoppe, HC Hoppe, I Mellman, J Schrevel, JB Dacks, JC Boothroyd, JE Rothman, JF Dubremetz, JM Harper, K Kremer, K Miranda, KA Joiner, KA Joiner, KM Hager, L Pelletier, L Sheiner, LH Bannister, LH Bannister, LM Kats, M Elias, M Tufet-Bayona, M Yang, Markus Meissner, ME Francia, MH Ngo, MH Ngo, MK Shaw, MS Breinich, MS Marks, NA Counihan, PJ Bradley, PJ Sloves, S Mogelsvang, SD Brydges, Stanislas Tomavo, VB Carruthers, Vern B. Carruthers, WM Henne, X Que, Z Dou   +54 more
core   +2 more sources

The Parkinson's Disease Protein LRRK2 Interacts with the GARP Complex to Promote Retrograde Transport to the trans-Golgi Network. [PDF]

Cell Rep, 2020
Summary: Mutations in Leucine-rich repeat kinase 2 (LRRK2) cause Parkinson’s disease (PD). However, the precise function of LRRK2 remains unclear. We report an interaction between LRRK2 and VPS52, a subunit of the Golgi-associated retrograde protein ...
Beilina A, Bonet-Ponce L, Kumaran R, Kordich JJ, Ishida M, Mamais A, Kaganovich A, Saez-Atienzar S, Gershlick DC, Roosen DA, Pellegrini L, Malkov V, Fell MJ, Harvey K, Bonifacino JS, Moore DJ, Cookson MR.   +16 more
europepmc   +2 more sources

Regulation of cargo export and sorting at the trans‐Golgi network [PDF]

FEBS Letters, 2019
The sorting and distribution to different final destinations of roughly a third of the membrane and secreted proteins occurs at the level of the trans‐Golgi network (TGN). This TGN mission involves efficient mechanisms of cargo recognition and activation of specific signalling pathways.
Di Martino Rosaria, Sticco Lucia, Luini Alberto   +2 more
openaire   +2 more sources

Golgi Apparatus: A Potential Therapeutic Target for Autophagy-Associated Neurological Diseases

Frontiers in Cell and Developmental Biology, 2020
Autophagy has dual effects in human diseases: appropriate autophagy may protect cells from stress, while excessive autophagy may cause cell death. Additionally, close interactions exist between autophagy and the Golgi.
Shuwen Deng, Jia Liu, Xiaomei Wu, Wei Lu
doaj   +1 more source