Results 61 to 70 of about 366,682 (319)

High Availability and Load Balancing Solution Development in High Load Distributed Systems of Electronic Payments

Безопасность информационных технологий, 2012
A review of several solutions for comfortable work in systems with a large number of short transactions has been produced in the work. Several common cluster design schemes of providing data identity between the nodes have been analyzed as well as ...
V. M. Nichiporchuk, V. V. Lopatkin
doaj  

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Enhancing blockchain scalability with snake optimization algorithm: a novel approach

Frontiers in Blockchain
Scalability remains a critical challenge for blockchain technology, limiting its potential for widespread adoption in high-demand transactional systems.
Shimal S. H. Taher, Siddeeq Y. Ameen, Jihan A. Ahmed   +2 more
doaj   +1 more source

Application Programming Interface (API) And Management of Web-Based Accounting Information System (AIS): Security of Transaction Processing System, General Ledger and Financial Reporting System [PDF]

, 2023
Olubunmi Omotayo EFUNTADE, Alani Olusegun Efuntade   +1 more
openalex   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Distributed Transaction Processing Mechanism with High Scalability for Information Network Model [PDF]

Jisuanji gongcheng, 2017
The rapid increase in the amount of data have driven many database systems to provide nearlinearly scalability,but most of these systems cannot automatically maintain the strong consistent relation among objects.Aiming at this problem,this paper designs ...
ZHANG Jian,LIU Mengchi
doaj   +1 more source

Integrating E-Commerce and Data Mining: Architecture and Challenges [PDF]

, 2000
We show that the e-commerce domain can provide all the right ingredients for successful data mining and claim that it is a killer domain for data mining.
Ansari, Suhail, Kohavi, Ron, Mason, Llew, Zheng, Zijian   +3 more
core   +5 more sources

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

ANALYSIS OF THE IMPACT OF SHARDING ON THE SCALABILITY AND EFFICIENCY OF BLOCKCHAIN TECHNOLOGIES FOR THE CREATION OF INFORMATION-ANALYTICAL SYSTEMS FOR ENVIRONMENTAL MONITORING OF EMISSIONS INTO THE ENVIRONMENT

Scientific Journal of Astana IT University
This study examines the impact of sharding on the scalability and efficiency of blockchain systems, specifically in the development of a complex of intelligent information and communication systems for environmental monitoring of emissions into the ...
Sapar Toxanov, Saltanat Sharipova, Andrii Biloshchytskyi, Dilara Abzhanova, Batyrbek Bakytkereiuly   +4 more
doaj   +1 more source