Results 81 to 90 of about 292,424 (340)

Potent Liver‐Tropic mRNA Lipid Nanoparticles: ApoE‐Mediated Delivery Through a Low‐Density Lipoprotein Receptor Independent Uptake Mechanism

Advanced Materials, EarlyView.
Helper and ionizable lipids play a crucial role in determining ApoE binding and subsequent liver tropism and LDLR‐mediated uptake. Ionizable lipids primarily govern the LDLR‐independent uptake pathway. This complementary interplay between lipid components ultimately governs LNP delivery performance and therapeutic efficacy in the liver.
Ashish Sarode, Christian Ortiz, Tadeh Derstepanian, Natalia Vargas‐Montoya, Priyal Patel, Nikita Khadse, Saikat Manna, Ryan Landis, Joseph Skaleski, Lianne Boeglin, Hongfeng Deng, Anusha Dias, Hong Wang, Debora Barreiros Petropolis, Barak Yahalom, Shrirang Karve, Frank DeRosa   +16 more
wiley   +1 more source

Termoativação da transaminase glutâmico oxaloacética

Memorias do Instituto Oswaldo Cruz, 1973
Estudou-se a atividade da transaminase glutâmico oxaloacética (TGO) em diferentes tecidos (fígado, músculo, rim, pulmão, baço e soro sanguíneo) de ratos e de soro humano.
Hélion Póvoa Júnior, Paulo Cesar Carvalho de Almeida, Orlando O. Alves, Neusa Marcondes   +3 more
doaj   +1 more source

Immune- and nonimmune-compartment-specific interferon responses are critical determinants of herpes simplex virus-induced generalized infections and acute liver failure [PDF]

, 2016
The interferon (IFN) response to viral pathogens is critical for host survival. In humans and mouse models, defects in IFN responses can result in lethal herpes simplex virus 1 (HSV-1) infections, usually from encephalitis.
Leib, David A, Parker, George A, Parker, Zachary M, Pasieka, Tracy Jo   +3 more
core   +3 more sources

Serotonergic System‐Targeted Nucleic Acid Hydrogel Coordinates Excitability Restoration and Circuit Reconstruction for Spinal Cord Injury Therapy

Advanced Materials, EarlyView.
The study reports a DNA/RNA heteroduplex hydrogel (SeroPTEN‐CG) that undergoes DNase‐mediated hydrogel‐to‐nanogel transition for spinal cord injury therapy by targeting the serotonergic system, combining 5‐hydroxytryptamine (5‐HT)‐mediated excitability restoration to reactivate dormant interneurons with phosphatase and tensin homolog (PTEN)‐targeted ...
Chunlin Li, Xiaoqing Zhao, Kai Jiang, Haixia Kang, Shuo Liu, Linlin Jiang, Baoshuai Bai, Haonan Cui, Ziyang Zhang, Menglei Dong, Ruizhi Zhang, Chenbo Zou, Shenghui Shang, Chi Zhang, Xiangchuang Fan, Lijuan Zhu, Huiquan Duan, Chuan Zhang, Shiqing Feng, Hengxing Zhou   +19 more
wiley   +1 more source

The Effects of Heavy Metal Contamination on Liver Function in a Rat Model

Magna Medika
Background:  Mining activities in South Kalimantan have been widely associated with the emergence of various health issues through heavy metal contamination in the water.
Ida Yuliana, Triawanti Triawanti, Muhammad Darwin Prenggono, Ika Kustiyah Oktaviyanti, Asnawati Asnawati, Fahrina Ulfah, Irfan Maulana   +6 more
doaj   +1 more source

Caracterização de variedades de batata doce (Ipomoea batatas L.) através de descritores morfológicos e isoenzimáticos Morphological and isoenzymatic characterization of sweet potato (Ipomoea batatas L.)

Ciência Rural, 2000
Ocorre grande variabilidade no germoplasma de batata-doce disponível no Rio Grande do Sul, mas nem todas populações podem ser caracterizadas através de aspectos morfológicos, havendo necessidade de recorrer a outros métodos, como análise de isoenzimas ...
Eliane Augustin, Alseny Garcia, Beatriz Helena Gomes Rocha   +2 more
doaj   +1 more source

Dual‐Functional Ingestible Passive Capsules for High‐Throughput Intestinal Sampling with Sealed Containment and Targeted Drug Delivery

Advanced Robotics Research, EarlyView.
To address challenges in high‐throughput intestinal sampling with sealed containment and target drug delivery, we developed a dual‐functional ingestible passive capsule with a dual‐triggered control system based on pH‐response and mechanical actuation.
Libing Huang, Houyu Ling, Xizong Chen, Yufei Duan, Yu Liu, Shuntian Cai, Yandan Ren, Wenlong Li, Lei Ren, Miao Wang   +9 more
wiley   +1 more source

Early postoperative liver function parameters as predictors of post-hepatectomy liver failure

Frontiers in Surgery
BackgroundPost-hepatectomy liver failure (PHLF) is a serious complication after liver resection and is associated with increased morbidity and mortality.
Schaima Abdelhadi, Mohamad El-Ahmar, Katharina Vedder, Mahmoud Halawa, Vanessa Orth, Maike Hermann, Meik Mönnichs, Georgi Vassilev, Christoph Reissfelder, Christoph Reissfelder, Flavius Sandra-Petrescu   +10 more
doaj   +1 more source

Serum Transaminase in Duchenne Dystrophy

Pediatric Neurology Briefs, 2011
Researchers at Children’s Hospital Boston, MA, have shown a linear relationship between serum CPK and serum ALT and AST and a logarithmic relationship between serum enzyme levels and age for boys with Duchenne (n=46) or Becker (n=9) muscular dystrophy ...
J Gordon Millichap
doaj   +1 more source

Prognostic Role of Pretreatment De Ritis Ratio (Aspartate Transaminase/Alanine Transaminase Ratio) in Urological Cancers: A Systematic Review and Meta-Analysis

Frontiers in Oncology, 2020
Background: To examine the potential prognostic significance of pretreatment De Ritis ratio (aspartate transaminase/alanine transaminase ratio) in urological cancers, including upper tract urothelial cancer (UTUC), renal cell carcinoma (RCC), prostate ...
Shiqiang Su, Lizhe Liu, Chao Li, Jin Zhang, Shen Li   +4 more
doaj   +1 more source