Results 111 to 120 of about 77,314 (347)

Development and Validation of Machine Learning‐Based Marker for Early Detection and Prognosis Stratification of Nonalcoholic Fatty Liver Disease

Advanced Science, EarlyView.
This study constructs a stacked multimodal machine learning model for nonalcoholic fattly liver disease (NAFLD) by integrating genetic and clinical features, and synthesize an in‐silico quantitative marker (ISNLD) that enables personalized risk stratification for intrahepatic and extrahepatic outcomes of high‐risk individuals of NAFLD.
Lushan Xiao, Lin Zeng, Jiaren Wang, Chang Hong, Ziyong Zhang, Chengkai Wu, Hao Cui, Yan Li, Ruining Li, Shengxing Liang, Qijie Deng, Wenyuan Li, Xuejing Zou, Pengcheng Ma, Li Liu   +14 more
wiley   +1 more source

Improvement of neutropenia in 2 adolescent cases treated with empagliflozin for glycogen storage disease type Ib [PDF]

Pediatric Emergency Medicine Journal
Neutropenia and elevated concentrations of hepatic transaminases often lead to referrals from emergency or outpatient departments to relevant specialists to diagnose underlying inborn errors of metabolism.
Hyunwoo Bae
doaj   +1 more source

Serum Lactic Dehydrogenase and Serum Transaminase in Human Leukemia [PDF]

, 1959
Gordon B. Magill, Felix Wróblewski, John S. LaDue   +2 more
openalex   +1 more source

Muscular Dystrophy and Transaminases

The Journal of Kartal Training and Research Hospital, 2014
Bulgular: Yaslari 5-10 yas arasi olan 11 cocuk degerlendirildi. Hastalarin 9’u erkek (%81.8) ve 2’si (%18.2) kiz idi. Fizik muayenede tum cocuklarin boy ve kilosu 3. persentilin uzerinde ve hepsinin norolojik gelisimi normal bulundu. Bes erkek cocukta (%45.5) gastroknemius kasinda hipertrofi saptandi. ALT seviyesi 70-2400 IU/L arasinda, AST seviyesi 70-
Meltem Ugras, Canan Kocaman Yıldırım, Ayça Vitrinel, Öznur Küçük   +3 more
openaire   +2 more sources

Phase Ib study of the combination of pexidartinib (PLX3397), a CSF-1R inhibitor, and paclitaxel in patients with advanced solid tumors. [PDF]

, 2019
Purpose:To evaluate the safety, recommended phase II dose (RP2D) and efficacy of pexidartinib, a colony stimulating factor receptor 1 (CSF-1R) inhibitor, in combination with weekly paclitaxel in patients with advanced solid tumors.
Coussens, Lisa M, Dowlati, Afshin, Karlin, David A, Le, Mai H, Marimuthu, Adhirai, Peck, Alexandra, Reebel, Laura, Rodal, Mary Beth, Rugo, Hope S, Severson, Paul, Sharma, Neelesh, Wesolowski, Robert, West, Brian L   +12 more
core  

Profiling and targeting HER2-positive breast cancer using trastuzumab emtansine. [PDF]

, 2014
PurposeThis article reviews the mechanism of action of trastuzumab emtansine (T-DM1), existing clinical data relating to its use for human growth factor receptor 2 (HER2)-positive breast cancer, potential pathways of resistance, and ongoing studies ...
Hurvitz, Sara A, Olevsky, Olga, Sadeghi, Saeed   +2 more
core   +1 more source

Efficient and Specific PDGFRβ‐Targeting Dual‐Mode T1‐T2 MRI Nanoprobe for Early Diagnosis of Non‐Alcoholic Fatty Liver

Advanced Science, EarlyView.
The Fe3O4/Gd@BSA‐pPB nanoprobe leverages biomimetic mineralization and targets hepatic stellate cells (HSCs) through PDGFRβ, offering superior enrichment in fibrotic regions. This targeted delivery overcomes biological barriers, enhancing both the accuracy and sensitivity of MRI imaging at early disease stages.
Zehua Li, Tongwei Zhang, Tongxiang Tao, Yaxuan Liu, Haining Xia, Sajid ur Rehman, Zeyong Guo, Jing Zhang, Ruiguo Chen, Zhan Zhang, Junfeng Wang, Kun Ma   +11 more
wiley   +1 more source

Cytogenetic, Hematobiochemical, and Histopathological Assessment of Albino Rats (Rattus norvegicus) Fed on Gluten Extracts [PDF]

arXiv
Background: Literature shows that most of the information on the toxicity of gluten is generated from survey and observational studies, resulting in inconsistent outcomes and a decrease in the acceptability of gluten-rich foods. To determine gluten's safety, an in-depth in vitro and in vivo toxicological examination is required. This enables scientists
arxiv  

piR‐RCC Suppresses Renal Cell Carcinoma Progression by Facilitating YBX‐1 Cytoplasm Localization

Advanced Science, EarlyView.
PIWI‐interacting RNAs (piRNAs), a novel category of small non‐coding RNAs, have been implicated in the development of various diseases. This study explores the tumor‐suppressive mechanism of a downregulated piRNA (designated piR‐RCC) in renal cell carcinoma (RCC), and provides a delivery strategy targeting RCC tumor by constructing a cell membrane ...
Ruyue Wang, Fan Li, Yudong Lin, Zeyi Lu, Wenqin Luo, Zhehao Xu, Ziwei Zhu, Yi Lu, Xudong Mao, Yang Li, Zhinian Shen, Haohua Lu, Yining Chen, Liqun Xia, Mingchao Wang, Lifeng Ding, Gonghui Li   +16 more
wiley   +1 more source

Liver transplantation for type I and type IV glycogen storage disease [PDF]

, 1993
Progressive liver failure or hepatic complications of the primary disease led to orthotopic liver transplantation in eight children with glycogen storage disease over a 9-year period.
A. G. Tzakis, AS Guerra, B Illingworth, B. I. Brown, BI Brown, BI Brown, BI Brown, CA Alper, D Raum, DA Merrill, E. Yunis, GA Bannayan, GB Reed, GM Greene, GT Cori, H Zellweger, HG Hers, HL Greene, IT Ferguson, JJ Malatack, JJ Siekierka, KR McMaster, MW Harding, N Kashiwagi, N Kashiwagi, R. S. Kendall, R. Selby, RC Nordlie, S Servidei, S. Todo, T Ishihara, T. E. Starzl, TE Starl, TE Starzl, TE Starzl, TE Starzl, TE Starzl, V Mazzaferro   +37 more
core   +1 more source