Results 191 to 200 of about 114,148 (343)

Conversion of Transplanted Mature Hepatocytes into Afp+ Reprogrammed Cells for Liver Regeneration After Injury

Advanced Science, EarlyView.
Donor‐derived tdTomato+ mature hepatocytes were FACS‐isolated and transplanted into Fah−/− host mice. During regeneration, these cells convert into proliferative, unipotent Afp+ rHeps. Their plasticity is governed by a PPARγ/AFP‐dependent metabolic switch, segregating into pro‐proliferative Afplow and pro‐survival Afphigh subpopulations.
Ting Fang, Chao Yang, Hua Qiu, Yuan Du, Xicheng Wang, Yuting Li, Mingyang Xu, Changcheng Liu, Xiuhua Li, Na Guo, Jun Shi, Wencheng Zhang, Zhiying He   +12 more
wiley   +1 more source

Hepatic Glycogenosis Resulting in Hyperammonemia in a Young Adult With Type 1 Diabetes Mellitus. [PDF]

JCEM Case Rep
Dinh CB, Ghaben AL, Newfield RS.
europepmc   +1 more source

Glutamine‐utilizing transaminases are a metabolic vulnerability of TAZ/YAP‐activated cancer cells

EMBO Reports, 2018
Chih-Sheng Yang, Eleni Stampouloglou, N. Kingston, Liye Zhang, S. Monti, X. Varelas   +5 more
semanticscholar   +1 more source

Regulation of Branched Chain Amino Acid Transaminase Formation During the Growth of Pseudomonas fluorescens UK-1. [PDF]

, 1972
M. Puukka, Harri Lönnberg, Veikko Nurmikko, R.-L. Pajula, Veikko Nurmikko   +4 more
openalex   +1 more source

Development of an Amine Transaminase-Lipase Cascade for Chiral Amide Synthesis under Flow Conditions

, 2023
Antía Pintor, Ashley P. Mattey, Iván Lavandera, Vicente Gotor‐Fernández, Alexey Volkov   +4 more
openalex   +1 more source

Smart Nanoparticles Disrupting Energy Supply through Triple Mechanisms to Kill Tumors via Dual Disruption of Mitochondria and Lysosomes

Advanced Science, EarlyView.
This study introduces a biomimetic nanoplatform (MTCA@C) designed for precise cancer therapy. It targets mitochondria to induce dysfunction through photodynamic activation, while concurrently blocking mitophagy via lysosomal alkalinization. The platform further triggers methuosis, resulting in tumor cell death through vacuolization and energy pathway ...
Xiao Xu, Qiqing Huang, Yang Liu, Jinzhuo Liu, Deyi Yang, Yanni Song, Xin Han   +6 more
wiley   +1 more source

Ibrutinib-Associated Liver Injury in a Patient with Chronic Lymphocytic Leukemia: Clinical Course and Therapeutic Approach. [PDF]

Hematol Rep
Frolli A, Parvis G, Bullo M, Grano S, Fornari G, Bonuomo V, Cilloni D, Fava C.   +7 more
europepmc   +1 more source

Integrin β3 Orchestrates Hepatic Steatosis via a Novel CD36‐Dependent Lipid Uptake Complex

Advanced Science, EarlyView.
In MASH, ITGB3 recruits LYN and drives its ubiquitin‐proteasomal degradation via phosphorylation. This relieves DHHC5 inhibition, enabling ITGB3/DHHC5/CD36 complex assembly to enhance CD36 palmitoylation and fatty acid uptake, thereby exacerbating disease. Targeting ITGB3 blocks this pathogenic axis and ameliorates MASH.
Ying Zhang, Lei Dai, Zhongquan Cui, Ye Zhou, Wenyuan Dong, Hongcheng Jiang, Mengwen Wang, Xiaodan Zhong, Wei Dong, Zhang Yue, Thati Madhusudhan, Hongjie Wang, Xiong Zhong Ruan, Hesong Zeng   +13 more
wiley   +1 more source

A Case of Acetaminophen Toxicity in a Patient With an Unusual Alpha-1 Antitrypsin Phenotype. [PDF]

Cureus
Agrawal A, Chowdhury M, Winkie C, Vijay C.   +3 more
europepmc   +1 more source

Explaining Operational Instability of Amine Transaminases: Substrate-Induced Inactivation Mechanism and Influence of Quaternary Structure on Enzyme-Cofactor Intermediate Stability.

, 2017
Tim Börner, S. Rämisch, E. Reddem, S. Bartsch, A. Vogel, A. Thunnissen, P. Adlercreutz, Carl Grey   +7 more
semanticscholar   +1 more source