Results 191 to 200 of about 137,846 (394)

Neoadjuvant Chemotherapy With Cisplatin Up‐Regulates GSDMD to Enhance Oral Squamous Cell Carcinoma Metastasis Through MMP14‐Mediated EMT Activation

open access: yesAdvanced Science, EarlyView.
Oral squamous cell carcinoma cells exhibit upregulated expression of GSDMD upon exposure to low‐dose cisplatin chemotherapy, which subsequently interacts with MMP14 through its N‐terminal domain, activating the epithelial‒mesenchymal transition (EMT) process and promoting the lymph node metastasis of oral squamous cell carcinoma.
Zixian Huang   +9 more
wiley   +1 more source

Late-onset Pompe Disease with Elevated Liver Transaminases: A Case Report

open access: yesJournal of Mazandaran University of Medical Sciences, 2019
Pompe disease or type II glycogen storage disease is a rare autosomal hereditary disease. The prevalence of the disease is about 1 in 40,000 to 1 in 300,000 population. It usually occurs as a result of glycogen accretion following acid maltase deficiency.
Maryam Bagheri   +2 more
doaj  

Hematological profile, inflammatory markers and serum liver enzymes in COVID 19 positive children vs. COVID 19 negative ones—a comparative study

open access: yesFrontiers in Pediatrics
BackgroundComplete blood count, C-reactive protein and transaminases are routine laboratory parameters investigated in children with infections, including COVID 19.
Mirela Luminița Pavelescu   +8 more
doaj   +1 more source

Action of Phenylalanine Metabolites on Glutamic Acid Decarboxylase and gamma-Aminobutyric Acid---alpha-Ketoglutaric Acid Transaminase in Brain. [PDF]

open access: bronze, 1959
Arne Hanson   +5 more
openalex   +1 more source

Endothelial dysfunction in adolescents and young adults with nonalcoholic liver disease [PDF]

open access: yes, 2019
Nonalcoholic liver disease is a global public health problem that increases cardiovascular morbidity and mortality in these patients. This paper discusses endothelial dysfunction among patients (adolescents and young adults) with nonalcoholic liver ...
Donoiu, Ionuț   +6 more
core   +1 more source

Responsive ROS‐Augmented Prodrug Hybridization Nanoassemblies for Multidimensionally Synergitic Treatment of Hepatocellular Carcinoma in Cascade Assaults

open access: yesAdvanced Science, EarlyView.
This study proposes a novel HCC therapy using CA‐4S2@ES‐Cu nanomedicines to amplify cuproptosis, enhancing chemotherapy and immunotherapy. CA‐4 and ES‐Cu synergistically inhibit tumor growth, induce immune responses, and reverse the immunosuppressive microenvironment, offering an effective multidimensional therapeutic strategy for HCC treatment ...
Yingjie Zeng   +16 more
wiley   +1 more source

A MXene‐Based Nanothermal Knife Inhibits Aggresome‐Mediated Persister Formation for Preventing Dental Caries

open access: yesAdvanced Science, EarlyView.
Early childhood caries (ECC) involves cariogenic persisters that evade antimicrobial treatment. Persisters achieve this by downregulating heat shock proteins (HSPs) and formation of protein aggregates. Ti3C2 MXene‐based photothermal therapy (PTT) acts as a “nanothermal knife,” disrupting membranes, upregulating HSPs, inhibits aggregates, prevents ...
Yinyin Zhang   +8 more
wiley   +1 more source

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