Results 41 to 50 of about 114,148 (343)

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Self-Sufficient Flow-Biocatalysis by Coimmobilization of Pyridoxal 5′-Phosphate and ω-Transaminases onto Porous Carriers

ACS Sustainable Chemistry and Engineering, 2018
We expanded the application of self-sufficient heterogeneous biocatalysts containing coimmobilized ω-transaminases and pyridoxal 5′-phosphate (PLP) to efficiently operate packed-bed reactors in continuous flow.
A. I. Benítez-Mateos, M. Contente, Susana Velasco-Lozano, F. Paradisi, F. López‐Gallego   +4 more
semanticscholar   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Routine Laboratory Parameter Dynamics and Laboratory Adverse Events in Psoriasis Patients on Long-term Treatment with Adalimumab, Etanercept, and Ustekinumab

Acta Dermato-Venereologica, 2017
Only limited data on laboratory parameter dynamics and safety under prolonged biologic treatment in a “real-world” scenario are available for recommendations on screening and monitoring.
Jochen H. Hoffmann, Christian Knoop, Alexander H. Enk, Eva N. Hadaschik   +3 more
doaj   +1 more source

Hepatotoxicity Evaluation of Aqueous Extract from Scutia buxifolia

Molecules, 2013
Nowadays there is an increase in the number of people taking herbals worldwide. Scutia buxifolia is used for the treatment of hypertension, but little is known about its action on liver.
Margareth Linde Athayde, Liliane de Freitas Bauermann, Isabel Cristina da Costa Araldi, Rafael Noal Moresco, Helena Kober, Roberta da Silva Jesus, Carolina Fantinel Veloso, Mariana Piana, Thiele Faccim de Brum, Aline Augusti Boligon, Bruno Tomazele Rovani, Robson Borba de Freitas   +11 more
doaj   +1 more source

Adequacy of the 10 mg/kg Daily Dose of Antituberculosis Drug Isoniazid in Infants under 6 Months of Age

Antibiotics, 2023
In 2010, the WHO recommended an increase in the daily doses of first-line anti-tuberculosis medicines in children. We aim to characterize the pharmacokinetics of the once-daily isoniazid (INH) dose at 10 mg/kg of body weight in infants 3 mg/L and 11.6–26.
Maria Goretti López-Ramos, Joan Vinent, Rob Aarnoutse, Angela Colbers, Eneritz Velasco-Arnaiz, Loreto Martorell, Lola Falcón-Neyra, Olaf Neth, Luis Prieto, Sara Guillén, Fernando Baquero-Artigao, Ana Méndez-Echevarría, David Gómez-Pastrana, Ana Belén Jiménez, Rebeca Lahoz, José Tomás Ramos-Amador, Antoni Soriano-Arandes, Begoña Santiago, Rosa Farré, Clàudia Fortuny, Dolors Soy, Antoni Noguera-Julian   +21 more
doaj   +1 more source

Clinical significance of elevated liver transaminases in HIV-infected patients.

AIDS (London), 2019
: Elevation of liver transaminases is common in patients infected with the HIV. Although this is usually an incidental finding during regular work-up, HIV-infected patients with transaminase elevations require additional visits for laboratory studies and
Jia-Hui Cai, M. Osikowicz, G. Sebastiani
semanticscholar   +1 more source

Serum Uric Acid Levels in Older Adults: Associations With Clinical Outcomes and Implications for Reference Intervals in Those Aged 70 Years and Over

Arthritis Care &Research, EarlyView.
Objective Reports have linked both high and low serum uric acid (SUA) levels to adverse health outcomes. This study aimed to establish a reference interval for SUA in older adults and assessed its association with clinically relevant outcomes in relatively healthy, community‐dwelling individuals aged ≥70 years old.
Amanda J. Rickard, Cammie Tran, Hans G. Schneider, Flavia M. Cicuttini, Anita E. Wluka, Ego Seeman, Johannes T. Neumann, Md Nazmul Karim, Zhen Zhou, Sultana Monira Hussain, David P. Q. Clark, Daniel Clayton‐Chubb, Andrew M. Tonkin, Lawrence J. Beilin, Robyn L. Woods, John J. McNeil   +15 more
wiley   +1 more source

The effect of isotretinoin on triglycerides and liver aminotransferases Influência da isotretinoína nas transaminases hepáticas e triglicerídeos

Anais Brasileiros de Dermatologia, 2012
BACKGROUND: Isotretinoin has been used to treat the most severe cases of acne; however, it may provoke adverse events in mucocutaneous and hepatic tissues, lead to alterations in lipid levels and cause teratogenicity.
Andreia Salezze Vieira, Vanessa Beijamini, Ana Carolina Melchiors   +2 more
doaj   +1 more source

The clinical profile, hematological parameters and liver transaminases of dengue NS1 Ag positive patients admitted to Jaffna Teaching Hospital, Sri Lanka

BMC Research Notes, 2019
Objective of the study is to evaluate the on-admission day symptoms and signs, clinical, hematological parameters and liver transaminases of the dengue NS1 positive patients who got admitted on different clinical phases [Febrile phase (day 1–3) and ...
T. Jayadas, T. Kumanan, V. Arasaratnam, K. Gajapathy, S. Surendran   +4 more
semanticscholar   +1 more source