Results 11 to 20 of about 390 (152)
The role of transcobalamins in vitamin B12 metabolism [PDF]
, 1976 available : p.9 ...
MacDonald, Caroline Mary Leslie Anne
core +7 more sources
Unexplained Elevated Vitamin B12: Consider Macro-B12. [PDF]
Int J Lab HematolABSTRACT Introduction Elevated vitamin B12 concentration can be caused by supplementation, liver disease, kidney disease, or myeloid malignancies. Persistent, unexplained elevations of vitamin B12 can raise concern among patients and may lead to invasive diagnostic procedures, including bone marrow biopsy.
Hurkmans EGE +3 more
europepmc +2 more sources
Measurement of Transcobalamin by ELISA [PDF]
Clinical Chemistry, 2000 AbstractBackground: Transcobalamin is essential for the cellular internalization of cobalamin. Methods to quantify the unsaturated protein are available, but few attempts have been made to develop methods to quantify the sum of unsaturated and cobalamin saturated transcobalamin.Methods: γ-Globulins from two polyclonal rabbit antibodies against ...
Nexø, Ebba; id_orcid 0000-0001-9406-9081 +3 more
openaire +4 more sources
Direct Assay for Cobalamin Bound to Transcobalamin (Holo-Transcobalamin) in Serum [PDF]
Clinical Chemistry, 2002 Abstract Background: Only cobalamin carried by transcobalamin (holo-transcobalamin) is available for cellular uptake and hence is physiologically relevant. However, no reliable or accurate methods for quantifying holo-transcobalamin are available. We report a novel holo-transcobalamin assay based on solid-phase capture of transcobalamin.
Ulleland, M. +6 more
openaire +3 more sources
Mouse Transcobalamin Has Features Resembling both Human Transcobalamin and Haptocorrin [PDF]
PLoS ONE, 2011 In humans, the cobalamin (Cbl) -binding protein transcobalamin (TC) transports Cbl from the intestine and into all the cells of the body, whereas the glycoprotein haptocorrin (HC), which is present in both blood and exocrine secretions, is able to bind also corrinoids other than Cbl. The aim of this study is to explore the expression of the Cbl-binding
Hygum, Katrine +7 more
openaire +5 more sources
Aggregation of Transcobalamin II
Experimental Biology and Medicine, 1972 SummaryPurification of transcobalamin II prepared from normal serum by DEAE-cellulose column chromatography and polyacryalmide gel electrophoresis resulted in aggregation of this vitamin B12 binder. Exposure of transcobalamin II to 8 M urea resulted in liberation of the vitamin and aggregation of the binder.
L M, Meyer, E J, Gizis, C, Calas
openaire +2 more sources
Transport function of transcobalamin II [PDF]
Journal of Clinical Investigation, 1972 The uptake of free and bound (57)CoB(12), principally to transcobalamin II (TC II), was studied in isolated, perfused liver and kidney of the dog. (1) There was good uptake of canine TC II-B(12) by both organs. (2) In the liver TC II enhanced uptake over that of free B-12. (3) Renal uptake of free B-12 was greater than that of TC II-B(12).
M E, Rappazzo, C A, Hall
openaire +2 more sources
Measuring and Interpreting Holo-Transcobalamin (Holo-Transcobalamin II) [PDF]
Clinical Chemistry, 2002 At one time, diagnosing cobalamin deficiency was fairly simple, usually involving a patient with clinical problems, and was usually settled by determining whether the serum cobalamin concentration was low or not. As reviewed elsewhere (1), things began to change after sensitive metabolic tests were introduced and as attention extended to the cobalamin ...
openaire +1 more source
Heat Lability of Transcobalamin II
Experimental Biology and Medicine, 1971 Summary57Co B12 labeled normal serum was heated at 56° for 30 min and chromatographed on DEAE-cellulose columns, using the following sodium phosphate buffers for elution: 0.0175 M, pH 6.3; 0.04 M, pH 5.9; 0.1 M, pH 5.8, and 0.4 M, pH 5.2. The amount of bound 57Co B12 eluted with 0.04 M buffer decreased and that eluted with 0.1 and 0.4 M buffer ...
E J, Gizis, L M, Meyer
openaire +2 more sources
Journal of the Science of Food and Agriculture, EarlyView.Abstract BACKGROUND Diet‐induced inflammation is a major cause of muscle degeneration impacting human and animal health. Owing to their anti‐inflammatory and antioxidant properties, polyphenols have attracted considerable interest as feed additives.
Graziella Orso +8 more
wiley +1 more source