Results 21 to 30 of about 390 (152)

Bridging gaps in diabetic neuropathy care: A Delphi‐based regional consensus from the Gulf Cooperation Council

Journal of Diabetes Investigation, EarlyView.
A three‐round Delphi consensus developed GCC‐specific, evidence‐based recommendations for diabetic peripheral neuropathy (DPN) and painful diabetic neuropathy (PND). The consensus emphasizes proactive screening, early multimodal management, and addressing regional barriers to improve early detection, optimize management, and enhance quality of life ...
Abdulrahman Alshaikh, Abdulnabi T Alattar, Ahmed Abdul Karim Hassoun, Afaf Alshammary, Hussein Elbadawi, Khaled Aldossari, Noor Al Busaidi, Saud Alsifri, Talal Muzaffar, Wiam I. Hussein, Christine Talaat, Abanoub Effat, Marwa Elsaghier, Rayaz A Malik   +13 more
wiley   +1 more source

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

First Revision of the Guidelines for the Diagnosis and Management of Remethylation Disorders

Journal of Inherited Metabolic Disease, Volume 49, Issue 4, July 2026.
ABSTRACT This guideline summarizes diagnostic and therapeutic approaches based on a systematic literature review and evidence evaluation using the GRADE methodology. Given the limited high‐quality data, expert consensus was additionally obtained through a modified Delphi process.
Giorgia Olivieri, Andrea Bordugo, Birute Burnyte, Alessandro Costetti, Maria‐Luz Couce, Luisa Diogo, Francois Feillet, D. Sean Froese, Benedetta Greco, Jean‐Louis Gueant, Luciana Hannibal, Friederike Hörster, Viktor Kožich, Giancarlo La Marca, Irini Manoli, Fanny Mochel, Lorenzo Orazi, Belén Pérez, Manuel Schiff, Bernd C. Schwahn, Ida Schwartz, Karolina M. Stepien, Jolanta Sykut‐Cegielska, Trine Tangeraas, Rolf H. Zetterström, Carlo Dionisi‐Vici, Martina Huemer   +26 more
wiley   +1 more source

Vitamin‐Responsive Disorders: From Molecular Basis to Clinical Presentation and Therapy

Journal of Inherited Metabolic Disease, Volume 49, Issue 4, July 2026.
ABSTRACT Vitamin‐dependent cofactors are essential for numerous metabolic reactions, and defects affecting their uptake, conversion, utilisation, or regeneration constitute a heterogeneous group of inherited metabolic disorders (IMDs). Although dietary vitamin intake is sufficient to sustain coenzyme synthesis in healthy individuals, it is insufficient
Cécile Acquaviva, Yann Nadjar, Manuel Schiff, Christine Vianey‐Saban, Alain Fouilhoux, Jean‐François Benoist   +5 more
wiley   +1 more source

Acute Lung Injury: From Molecular Circuits to System‐Level Therapeutics

MedComm, Volume 7, Issue 6, June 2026.
This visual summary illustrates the paradigm shift from linear pathways to network medicine in ALI. Three interconnected circuits—innate immunity, immunometabolism, and cell death (PANoptosis)—drive disease progression under multiorgan crosstalk (gut–lung, brain–lung).
Yaoli Hou, Sheng He, Lili He, Kun Liu, Wen Tang, Deming Wang, Jing Gui, Zhiying Zeng, Yan Wang, Wenjie Liu, Ren Jing   +10 more
wiley   +1 more source

The Impact of Metformin on Vitamin B12 Levels in Children and Adolescents: A Systematic Review and Single‐Arm Meta‐Analysis

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 3, May 2026.
This first systematic review and single‐arm meta‐analysis in children and adolescents taking metformin found a significant vitamin B12 deficiency rate in observational studies than in randomised controlled trials (RCT). Larger RCTs with longer duration are recommended to better understand the risk.
Einas Abdullah Tahir, Muhtadi G. Ahmed, Motasam Belah Al Swayah, Sarah Mostafa Elsayed, Farhan Ahmed Alnoaimi, Ahmed Mohamed Hegazy, Nada Sayed Abdelalim, Rehab Adel Diab   +7 more
wiley   +1 more source

The Multifaceted Role of Keratinocytes in Hidradenitis Suppurativa Pathogenesis

Experimental Dermatology, Volume 35, Issue 5, May 2026.
ABSTRACT Hidradenitis suppurativa (HS) is a chronic autoinflammatory skin disorder of the pilosebaceous unit, with multiple factors contributing to its onset, activity and progression. Alongside a predisposing genetic background, hormonal and microbiome alterations, dysregulation of innate and adaptive immune response, as well as environmental ...
Chiara Moltrasio, Angelo Valerio Marzano, Maurizio Romagnuolo   +2 more
wiley   +1 more source

Discordant Vitamin B12 Results in an IgA Nephropathy Patient

Journal of Clinical Laboratory Analysis, Volume 40, Issue 5, March 2026.
ABSTRACT Background Discordant Vitamin B12 results can result from immunoassay interferences, potentially leading to unnecessary diagnostic procedures and misdiagnoses if not properly recognized. Case Presentation A 76‐year‐old male with a history of IgA nephropathy, hypertension, and other comorbidities presented with unexpectedly elevated total ...
Oytun Portakal, Nazende Işlak, Muhammed Ş. Binici, Yahya Büyükaşik   +3 more
wiley   +1 more source

VDLIN: A Deep Learning‐Based Platform for Methylcobalamin‐Inspired Immunomodulatory Compound Screening

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Using the convolutional neural network model VDLIN, Co7 is identified as a promising therapeutic candidate. Co7 demonstrates distinct advantages over MCB by effectively balancing anti‐inflammatory and immune‐stimulatory functions, making it a potential novel approach for immune modulation.
Xuefei Guo, Yang Zhao, Xianle Rong, Chenxi Niu, Shiyu Hu, Qiang Liu, Fuping You   +6 more
wiley   +1 more source

Transcobalamin (TC) deficiency and newborn screening [PDF]

Journal of Inherited Metabolic Disease, 2011
Dear Editor, We would like to update the readership about transcobalamin (TC) deficiency and newborn screening. In a recent article we described two siblings with TC deficiency (Prasad et al. 2008). The older child was clinically symptomatic with pancytopenia and his sister was diagnosed at birth by mutation analysis.
Chitra, Prasad, A E, Cairney, D S, Rosenblatt, C A, Rupar   +3 more
openaire   +2 more sources