Results 211 to 220 of about 5,189,368 (329)

The impact of Hnrnpl deficiency on transcriptional patterns of developing muscle cells

FEBS Open Bio, EarlyView.
We performed nanopore whole‐transcriptome sequencing comparing RNA from Hnrnpl‐knockdown versus control C2C12 myoblasts to investigate the contributions of Hnrnpl to muscle development. Our results indicate that Hnrnpl regulates the expression of genes involved with Notch signaling and skeletal muscle, particularly splicing patterns of specific muscle ...
Hannah R. Littel, Mekala Gunasekaran, Audrey L. Daugherty, Natalya M. Wells, Johnnie Turner, Christine C. Bruels, Christina A. Pacak, Isabelle Draper, Peter B. Kang   +8 more
wiley   +1 more source

Potential Genetic Markers Associated with Coloration in Duck: A Review. [PDF]

Int J Mol Sci
Khan MZ, Ma Q, Wang C, Peng Y, Zhu M, Wang C.   +5 more
europepmc   +1 more source

Mitochondria‐associated membranes (MAMs): molecular organization, cellular functions, and their role in health and disease

FEBS Open Bio, EarlyView.
Mitochondria‐associated membranes (MAMs) are contact sites between the endoplasmic reticulum and mitochondria that regulate calcium signaling, lipid metabolism, autophagy, and stress responses. This review outlines their molecular organization, roles in cellular homeostasis, and how dysfunction drives neurodegeneration, metabolic disease, cancer, and ...
Viet Bui, Maryline Santerre, Natalia Shcherbik, Bassel E Sawaya   +3 more
wiley   +1 more source

Genetic variation in the Nr1d1 transcription factor binding site shapes metabolism-related protein networks associated with cognitive resilience in an Alzheimer's disease mouse reference panel. [PDF]

Alzheimers Dement
Chen Y, Stevenson TK, Cao Y, Fish LA, Robbins JE, Merrihew GE, Park J, Hohman TJ, MacCoss MJ, Kaczorowski CC.   +9 more
europepmc   +1 more source

Editing the epigenome: technologies for programmable transcription and epigenetic modulation

Nature Methods, 2016
P. Thakore, Joshua B. Black, Isaac B. Hilton, C. Gersbach   +3 more
semanticscholar   +1 more source

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

The molecular aspects in prostatic cancer, unraveling the role of CDKs in prostate cancer progression. [PDF]

Discov Oncol
Farjami Z, Mohammadzadeh Z, Saifi B, Nezhad MT, Akbarin MM.   +4 more
europepmc   +1 more source

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

DNA, RNA, and histone methylation regulation enzymes and their crosstalk in colorectal carcinogenesis and progression: a review of molecular mechanisms, clinical implications, and future perspectives. [PDF]

Cell Mol Biol Lett
Qian S, Song H, Huang L, Hua H, Zhang X, Li Z, Pu M, Huang H, Zhang J.   +8 more
europepmc   +1 more source

SND1 Transcription Factor–Directed Quantitative Functional Hierarchical Genetic Regulatory Network in Wood Formation in Populus trichocarpa[C][W]

The Plant Cell, 2013
Y. Lin, Wei Li, Ying-Hsuan Sun, S. Kumari, Hairong Wei, Quanzi Li, Sermsawat Tunlaya-Anukit, R. Sederoff, V. Chiang   +8 more
semanticscholar   +1 more source