Results 231 to 240 of about 1,566,033 (293)

pka1 deletion induces hyperactivation of the transcription factor Mca1 and drives chromosome mis-segregation in Schizosaccharomyces pombe. [PDF]

Mol Genet Genomics
Yamawaki M, Nishioka S, Matsuo Y.
europepmc   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

The intersection of disorders of sex development and cardiovascular diseases. [PDF]

Biol Sex Differ
Hashmi S, Aherrahrou R.
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Research progress in the role and mechanism of GALNT3 in human diseases (Review). [PDF]

Biomed Rep
Su L, Lin Y, Hu X, Liu Z.
europepmc   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Genetic loci underlying seed size and yield-related traits in cowpea. [PDF]

Front Plant Sci
Iro Sodo AM, Fatokun C, Olasanmi B, Ongom PO, Dieng I, Boukar O.   +5 more
europepmc   +1 more source

Beyond the baseline: mapping the context-specific regulatory landscape of disease. [PDF]

Trends Genet
Gilad Y, Battle A.
europepmc   +1 more source

Genetics of CAKUT. [PDF]

Med Genet
Hilger AC, Westland R, Hoefele J.
europepmc   +1 more source

Keeping it centered: decoding the activities that regulate yeast histone H3 variant Cse4 and confine it to centromeres. [PDF]

Front Cell Dev Biol
Greco M, Klim J, De Wulf P.
europepmc   +1 more source