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Genetic Determinants of 5–Lipoxygenase Transcription
International Archives of Allergy and Immunology, 1999<b>Background: </b>5 Lipoxygenase (5–LO) is a critical enzyme in the production of the leukotrienes. We have identified a series of mutations in the 5–LO gene that modify gene transcription. These mutations consist of addition of an Sp–1 binding motif (–GGGCGG–) or deletion of one or two Sp–1 binding motifs in the 5–LO core promoter.
J M, Drazen, E S, Silverman
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Diversity of Regulation of Genetic Transcription
Nature New Biology, 1972Functional coupling of the translational machinery to transcription is obligatory for the transcription of some genes, including the trp operon, but not for others.
F, Imamoto, S, Tani
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Collinearity of Transcriptional and Traditional Genetic Maps
Nature New Biology, 1972THE transcriptional mapping method1 makes possible the detection of polycistronic operons in systems which are not amenable to fine structure genetic mapping. The theory behind transcriptional mapping is that a defined interference with the travel of the genetic transcribing enzyme can be used for genetic analysis in a variety of ways.
K S, Webb, M A, Bleyman
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Ionizing Radiation: Effect on Genetic Transcription
Science, 1964Cells of Escherichia coli grown on maltose can be induced by the addition of thiomethyl galactoside to produce β-galactosidase. If cells are irradiated shortly after induction, the transcription of the DNA ceases, and the enzyme produced by the messenger RNA is observed to reach a maximum.
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Nucleosomes and transcription: recent lessons from genetics
Current Opinion in Genetics & Development, 1997Substantial evidence exists that nucleosomes affect transcription and that additional factors modify nucleosome function. Recent work has demonstrated that different types of histone mutants can be classified by their distinct effects on transcription in vivo.
G A, Hartzog, F, Winston
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Transcription control reprogramming in genetic backup circuits
Nature Genetics, 2005A key question in molecular genetics is why severe mutations often do not result in a detectably abnormal phenotype. This robustness was partially ascribed to redundant paralogs that may provide backup for one another in case of mutation. Mining mutant viability and mRNA expression data in Saccharomyces cerevisiae, we found that backup was provided ...
Kafri, R., Bar-Even, A., Pilpel, Y.
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Genetic and Epigenetic Control of RKIP Transcription
Critical Reviews in Oncogenesis, 2014Raf kinase inhibitory protein (RKIP) is known to modulate key signaling cascades and regulate normal physiological processes such as cellular proliferation, differentiation, and apoptosis. The expression of RKIP is found to be downregulated in several cancer metastases and the repressed RKIP expression can be reactivated on treatment with ...
Ila, Datar +6 more
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Transcription factories: genetic programming in three dimensions
Current Opinion in Genetics & Development, 2012Among the most intensively studied systems in molecular biology is the eukaryotic transcriptional apparatus, which expresses genes in a regulated manner across hundreds of different cell types. Several studies over the past few years have added weight to the concept that transcription takes place within discrete 'transcription factories' assembled ...
Lucas Brandon, Edelman, Peter, Fraser
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Noise Propagation in Transcriptional Genetic Cascades
2023ABSTRACTCellular processes are inherently stochastic, leading to fluctuations in protein concentration quantifiable as noise in gene expression. Precise description of noise propagation in gene networks is essential for designing noise-tolerant gene circuits and understanding signal reliability in biological networks, but current models for noise ...
JD Marmolejo, JM Pedraza
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Transcription, Reverse Transcription, and Analysis of RNA Containing Artificial Genetic Components
ACS Synthetic Biology, 2014Expanding the synthetic biology of artificially expanded genetic information systems (AEGIS) requires tools to make and analyze RNA molecules having added nucleotide "letters". We report here the development of T7 RNA polymerase and reverse transcriptase to catalyze transcription and reverse transcription of xNA (DNA or RNA) having two complementary ...
Nicole A, Leal +5 more
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