Results 201 to 210 of about 2,206,258 (297)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Interplay between Epigenetic and Transcription Factors Mediating Drug Resistance via Stem Cells in Breast Cancer. [PDF]

ACS Omega
Barhela K, Chaudhary AA, Mishra R, Nupur N, Magani SKJ, Rudayni HA, Kumar S, Kumar B.   +7 more
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Host Factors Promoting the LTR Retrotransposon Life Cycle in Plant Cells: Current Knowledge and Future Directions. [PDF]

Int J Mol Sci
Merkulov P, Polkhovskiy A, Kamarauli E, Tiurin K, Soloviev A, Kirov I.   +5 more
europepmc   +1 more source

Signal-Induced Transcriptional Activation by Dif Requires the dTRAP80 Mediator Module

, 2003
Jin Mo Park, Jung Mo Kim, Lark Kyun Kim, Se Nyun Kim, Jeongsil Kim‐Ha, Jung Hoe Kim, Young‐Joon Kim   +6 more
openalex   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Primed to Burst: Corepressors Coordinate Transcriptional Activation and Efficient Switching Between Cell States. [PDF]

Bioessays
Leydon AR, Nemhauser JL.
europepmc   +1 more source

6-Mercaptopurine influences TPMT gene Transcription in a TPMT Gene Promoter Variable Number of Tandem Repeats-Dependent Manner

, 2012
Nikola Kotur, Biljana Stanković, Katerina Kassela, Marianthi Georgitsi, Anna Vicha, Iliana Leontari, Lidija Dokmanović, Dragana Janić, Nada Krstovski, Kristel Klaassen, Milena Radmilovic, Maja Stojiljković, Gordana Nikčević, Argiris Simeonidis, Gregory Sivolapenko, Sonja Pavlović, George P. Patrinos, Branka Zukić   +17 more
openalex   +2 more sources

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

Cockayne syndrome mutation in XPG activate the integrated stress response. [PDF]

Hum Genet
Zhang D, Hartmann M, Cao Z, Zhu G, Najjar G, Günes C, Emmert S, Scharffetter-Kochanek K, Iben S.   +8 more
europepmc   +1 more source