Results 101 to 110 of about 15,541,955 (379)

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

ChIP-on-chip significance analysis reveals large-scale binding and regulation by human transcription factor oncogenes [PDF]

, 2007
ChIP-on-chip has emerged as a powerful tool to dissect the complex network of regulatory interactions between transcription factors and their targets.
A. A. Ferrando, A. A. Margolin, A. Califano, Ashburner, Basso, Buck, Buck, Ferrando, G. Stolovitzky, Gibbons, Glynn, Hughes, Keles, Kim, Lee, Li, Matys, Miele, Odom, P. Sumazin, Palomero, Palomero, Pelengaris, Qi, Ren, Sandelin, T. Palomero, Weng   +27 more
core   +3 more sources

The nicotinamide hypothesis revisited—plant defense signaling integrating PARP, nicotinamide, nicotinic acid, epigenetics, and glutathione

FEBS Letters, EarlyView.
Nicotinamide (NIC) and nicotinic acid (NIA) are proposed as stress signaling compounds in plants. Oxidative stress may lead to single strand breaks (SSB) in DNA, which activate poly(ADP‐ribose) polymerase (PARP). NIC and NIA are then formed from NAD. NIC and NIA can promote epigenetic changes leading to the expression of defense genes specific for the ...
Torkel Berglund, Anna B. Ohlsson
wiley   +1 more source

A mouse tissue transcription factor atlas

Nature Communications, 2017
While we have abundant data for transcription factor (TF) binding sites and TF expression at the mRNA level, our knowledge of TFs at the protein level and their DNA-binding activities is sparser.
Quan Zhou, Mingwei Liu, Xia Xia, Tongqing Gong, Jinwen Feng, Wanlin Liu, Yang Liu, Bei Zhen, Yi Wang, Chen Ding, Jun Qin   +10 more
doaj   +1 more source

In silico analysis for the presence of HARDY an Arabidopsis drought tolerance DNA binding transcription factor product in chromosome 6 of Sorghum bicolor genome [PDF]

, 2009
Expression of the Arabidopsis HARDY (hrd) DNA binding transcription factor (555 bp present on chromosome 2) has been shown to increase WUE in rice by Karaba et al 2007 (PNAS, 104:15270–15275). We conducted a detail analysis of the complete sorghum
Arun K. Shanker, B Ventateswarlu, M Maheswari, S K. Yadav   +3 more
core   +2 more sources

Predicting variation of DNA shape preferences in protein-DNA interaction in cancer cells with a new biophysical model

, 2017
DNA shape readout is an important mechanism of target site recognition by transcription factors, in addition to the sequence readout. Several models of transcription factor-DNA binding which consider DNA shape have been developed in recent years.
Batmanov, Kirill, Wang, Junbai
core   +2 more sources

Single cis‐elements in brassinosteroid‐induced upregulated genes are insufficient to recruit both redox states of the BIL1/BZR1 DNA‐binding domain

FEBS Letters, EarlyView.
Phytohormone brassinosteroid‐induced gene regulation by the transcription factor BIL1/BZR1 involves redox‐dependent DNA‐binding alternation and interaction with the transcription factor PIF4. The reduced BIL1/BZR1 dimer binds preferred cis‐elements, while oxidation alters its oligomerization state and disrupts DNA‐binding ability.
Shohei Nosaki, Masae Ohtsuka, Takeshi Nakano, Masaru Tanokura, Takuya Miyakawa   +4 more
wiley   +1 more source

Protein Evolution in Yeast Transcription Factor Subnetworks [PDF]

, 2010
When averaged over the full yeast protein–protein interaction and transcriptional regulatory networks, protein hubs with many interaction partners or regulators tend to evolve significantly more slowly due to increased negative selection. However, genome-
Franzosa, Eric A., Wang, Yong, Xia, Yu, Zhang, Xiang-Sun   +3 more
core   +3 more sources

A working model for cytoplasmic assembly of H/ACA snoRNPs

FEBS Letters, EarlyView.
Dyskerin is the component of nuclear H/ACA ribonucleoproteins (RNPs) endowed with pseudouridine synthase catalytic activity. Two isoforms of human dyskerin have been characterized: the abundant Iso1, mainly nuclear, and the shorter Iso3, mainly cytoplasmic but occasionally imported into nuclei.
Alberto Angrisani, Maria Furia
wiley   +1 more source

The primary σ factor in Escherichia coli can access the transcription elongation complex from solution in vivo

eLife, 2015
The σ subunit of bacterial RNA polymerase (RNAP) confers on the enzyme the ability to initiate promoter-specific transcription. Although σ factors are generally classified as initiation factors, σ can also remain associated with, and modulate the ...
Seth R Goldman, Nikhil U Nair, Christopher D Wells, Bryce E Nickels, Ann Hochschild   +4 more
doaj   +1 more source