Results 101 to 110 of about 15,248,084 (403)

Unlocking a dark past. [PDF]

, 2018
A transcription factor called SALL4 could be the missing link between thalidomide and the limb defects caused by the ...
Borozdin, Brynner, Churcher, Donovan, Ito, Kohlhase, Kohlhase, Koshiba-Takeuchi, Krönke, Lenz, Lu, Petzold, Sakamoto   +12 more
core   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Coding limits on the number of transcription factors [PDF]

, 2006
Transcription factor proteins bind specific DNA sequences to control the expression of genes. They contain DNA binding domains which belong to several super-families, each with a specific mechanism of DNA binding.
Alon, Uri, Itzkovitz, Shalev, Tlusty, Tsvi   +2 more
core   +4 more sources

Purification tags markedly affect self‐aggregation of CPEB3

FEBS Letters, EarlyView.
Although recombinant proteins are used to study protein aggregation in vitro, uncleaved tags can interfere with accurate interpretation. Our findings demonstrate that His₆‐GFP and His₁₂ tags significantly affect liquid droplet and amyloid fibril formation in the intrinsically disordered region (IDR) of mouse cytoplasmic polyadenylation element‐binding ...
Harunobu Saito, Yujin Lee, Motoharu Ueno, Naotaka Sekiyama, Masatomo So, Ayako Furukawa, Kenji Sugase   +6 more
wiley   +1 more source

Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes

Autophagy, 2016
Autophagy is a highly coordinated process that is controlled at several levels including transcriptional regulation. Here, we identify the transcription factor NFE2L2/NRF2 (nuclear factor, erythroid 2 like 2) as a regulator of autophagy gene expression ...
Marta Pajares, Natalia Jiménez-Moreno, Á. J. García-Yagüe, M. Escoll, M. L. de Ceballos, F. van Leuven, A. Rábano, Masayuki Yamamoto, A. I. Rojo, A. Cuadrado   +9 more
semanticscholar   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

MYB transcription factor PdMYB118 directly interacts with bHLH transcription factor PdTT8 to regulate wound-induced anthocyanin biosynthesis in poplar

BMC Plant Biology, 2020
Background R2R3-MYB transcription factors (TFs) play important roles in plant growth and development, and response to biotic and abiotic stresses. However, their regulatory mechanisms in wound-induced anthocyanin biosynthesis in woody plants are largely ...
Haihai Wang, Xiaoqing Wang, Chunyan Yu, Cuiting Wang, Yanli Jin, Hongxia Zhang   +5 more
doaj   +1 more source

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

The primary σ factor in Escherichia coli can access the transcription elongation complex from solution in vivo

eLife, 2015
The σ subunit of bacterial RNA polymerase (RNAP) confers on the enzyme the ability to initiate promoter-specific transcription. Although σ factors are generally classified as initiation factors, σ can also remain associated with, and modulate the ...
Seth R Goldman, Nikhil U Nair, Christopher D Wells, Bryce E Nickels, Ann Hochschild   +4 more
doaj   +1 more source

Operator Sequence Alters Gene Expression Independently of Transcription Factor Occupancy in Bacteria [PDF]

, 2012
A canonical quantitative view of transcriptional regulation holds that the only role of operator sequence is to set the probability of transcription factor binding, with operator occupancy determining the level of gene expression.
Boedicker, James Q., Garcia, Hernan G., Gelles, Jeff, Kondev, Jane, Osborne, Melissa, Phillips, Rob, Sanchez, Alvaro   +6 more
core   +4 more sources