Results 221 to 230 of about 15,248,084 (403)

The adenovirus early region 4 open reading frame 6/7 protein regulates the DNA binding activity of the cellular transcription factor, E2F, through a direct complex. [PDF]

, 1989
Miller Huang, Patrick Hearing
openalex   +1 more source

Beyond cytotoxic T cells: reprogrammed regulatory T cells help facilitate response to dual checkpoint blockade

Molecular Oncology, EarlyView.
Rolig, Peng, and colleagues have shed new light on how dual blockade of PD1 and LAG3 enhances antitumor immunity. They found that response to immunotherapy with anti‐PD1 + anti‐LAG3 was associated with reprogramming of canonically suppressive CD4+ regulatory T cells to an inflammatory state.
Tullia C. Bruno, Anthony R. Cillo
wiley   +1 more source

Editorial: Bacterial transcription factors and the cell cycle, volume II

Frontiers in Microbiology, 2023
Morigen, Monika Glinkowska, Jianping Xie, Richa Priyadarshini, Kazutoshi Kasho   +4 more
doaj   +1 more source

Targeting the Undruggable: Recent Progress in PROTAC-Induced Transcription Factor Degradation. [PDF]

Cancers (Basel)
Jung H, Lee Y.
europepmc   +1 more source

Overlapping sites for constitutive and induced DNA binding factors involved in interferon-stimulated transcription. [PDF]

, 1989
Trevor Dale, Jeffrey M. Rosen, Matthew Guille, Andrew R. Lewin, Alan Porter, Ian M. Kerr, George R. Stark   +6 more
openalex   +1 more source

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

Molecular Oncology, EarlyView.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková, Marie Ehrlichová, Alžběta Spálenková, Ivona Krus, Simona Šůsová, Viktor Hlaváč, Vlasta Němcová, Renata Koževnikovová, Markéta Trnková, David Vrána, Jiří Gatěk, Kateřina Kopečková, Marcela Mrhalová, Soňa Měšťáková, Pavel Souček   +14 more
wiley   +1 more source

Small modifier, big decision: switching to SUMO mode adds weight to cancer stemness in mammary tumors

Molecular Oncology, EarlyView.
Inhibition of protein SUMOylation has been shown to block tumorigenesis; however, the specific mechanisms by which SUMOylation controls the tumor‐initiating capacities remain elusive. Li et al. describe the role of Etv1 SUMOylation in cancer stem cells using mouse models of mammary gland tumorigenesis.
Veronika Yevdokimova, Yannick D. Benoit
wiley   +1 more source

Promoter decoding of transcription factor dynamics

Molecular Systems Biology, 2013
Amie D Moody, Eric Batchelor
doaj   +1 more source

Interactions Between the Transcription Factor BOL/DRNL/ESR2 and the Jasmonate Pathway. [PDF]

Plants (Basel)
Ruiz-Cortés BE, Durán-Medina Y, Ramos-Tamayo CC, Guerrero-Largo H, Elizarraraz-Anaya MIC, Hernández-Zepeda OF, Ramírez-Chávez E, Lammers M, de Maagd RA, Molina-Torres J, de Folter S, Marsch-Martínez N.   +11 more
europepmc   +1 more source

Targeting carbonic anhydrase IX/XII prevents the anti‐ferroptotic effect of stromal lactic acid in prostate carcinoma

Molecular Oncology, EarlyView.
In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella, Giuseppina Comito, Luigi Ippolito, Erica Pranzini, Marta Iozzo, Giulia Gangarossa, Francesca Virgilio, Silvia Bua, Alessio Nocentini, Giada Sandrini, Nicla Lorito, Marina Bacci, Gabriella Nesi, Pietro Spatafora, Sergio Serni, Claudiu T. Supuran, Andrea Morandi, Paola Chiarugi, Elisa Giannoni   +18 more
wiley   +1 more source