Results 211 to 220 of about 4,565,651 (259)
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Transcription factors in autoimmunity
Current Opinion in Immunology, 2003The identification of two transcription factors that, when mutated, are responsible for severe autoimmune disease in humans is leading to a better understanding of the fundamental processes involved in T-cell tolerance. Both AIRE and FOXP3, identified initially via their association with genetically manipulated mice, are critically involved in ...
Fred, Ramsdell, Steven F, Ziegler
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TRANSCRIPTION FACTORS | Overview
2006The term ‘transcription factor’ refers to a large family of proteins, which exert transcriptional control via specific interactions with regulatory gene sequences. Here, we provide a summary of the different classes of the transcription factor divided according to their DNA-binding motifs. The modular structure of transcription factors and the presence
Adcock I. M., Ito K., CARAMORI, Gaetano
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Transcription Factors and Hypopituitarism
Trends in Endocrinology & Metabolism, 1999Several homeodomain factors are found in the developing anterior pituitary lobe. The production of these developmental transcription factors has distinct temporal and spatial patterns. By interacting with each other, as well as with other extrinsic and intrinsic signals, they control cell determination and specification.
, Cohen, , Radovick, , Wondisford
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Transcription factors and osteoblasts
Frontiers in Bioscience, 1998Transcription factors play a key role in determination of the fate of the cells in osteoblastic and chondrocytic lineage. A runt family member, Cbfa, is indispensable for osteoblastic differentiation. Sox 9 and scleraxis are involved in the phenotypic expression in chondrocytes and the cells of early stage connective tissues.
M, Noda +7 more
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Eukaryotic transcription factors
Current Opinion in Structural Biology, 1998The structural characterization of eukaryotic transcription factors that interact with DNA has advanced on two fronts in the past two years. New complexes of transcription factors bound to TATA-box DNA include the TFIIA-TBP-DNA complex as well as human and archaeal TBP-DNA and TFIIB-TBP-DNA complexes, respectively.
Tan S, Richmond TJ
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Molecular Biology, 2012
Transcription factor RUNX1 is one of the key regulatory proteins in vertebrates. It controls hematopoiesis and angiogenesis. It is indispensable during embryogenesis for the emergence of sites of definitive hematopoiesis and later in mature organisms for bone marrow blood stem cells differentiation.
E N, Markova +3 more
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Transcription factor RUNX1 is one of the key regulatory proteins in vertebrates. It controls hematopoiesis and angiogenesis. It is indispensable during embryogenesis for the emergence of sites of definitive hematopoiesis and later in mature organisms for bone marrow blood stem cells differentiation.
E N, Markova +3 more
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Transcription factors on the move
Trends in Genetics, 2001We think of transcription factors as being confined to the cell where they are transcribed, but recent work shows they are able to move from cell to cell in plants. Plant cells are thought to communicate through membrane-lined channels called plasmodesmata.
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Transcription factors: An overview
The International Journal of Biochemistry & Cell Biology, 1997This special issue of the International Journal of Biochemistry and Cell Biology contains a series of review articles and original papers dealing with the topic of transcription factors. The purpose of this introductory article is to provide an overview of these factors, their mechanism of action, their regulation and the manner in which alterations in
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2006
POU domain transcription factor proteins are critical regulators of many developmental processes during embryogenesis, are prominent in the neural system where they are identified as BRN transcription factors, and can be reactivated during malignant transformation of cancerous tissue. This family of genes is characterized by a common 150-160 amino acid
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POU domain transcription factor proteins are critical regulators of many developmental processes during embryogenesis, are prominent in the neural system where they are identified as BRN transcription factors, and can be reactivated during malignant transformation of cancerous tissue. This family of genes is characterized by a common 150-160 amino acid
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Trends in Plant Science, 2010
WRKY transcription factors are one of the largest families of transcriptional regulators in plants and form integral parts of signalling webs that modulate many plant processes. Here, we review recent significant progress in WRKY transcription factor research. New findings illustrate that WRKY proteins often act as repressors as well as activators, and
Rushton, P. +3 more
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WRKY transcription factors are one of the largest families of transcriptional regulators in plants and form integral parts of signalling webs that modulate many plant processes. Here, we review recent significant progress in WRKY transcription factor research. New findings illustrate that WRKY proteins often act as repressors as well as activators, and
Rushton, P. +3 more
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