Results 231 to 240 of about 1,824,501 (365)

A signal-responsive cooperative transcription factor network determines alveolar macrophage identity. [PDF]

J Exp Med
Mínguez-Martínez J, Porcuna J, Casablanca L, Gómez MJ, Aghelpasand H, Höjer P, García-Fojeda B, Núñez V, Torroja C, Mühleder S, Gustafsson C, Fischer T, Benedito R, Casals C, Månsson R, Sánchez-Cabo F, Ricote M.   +16 more
europepmc   +1 more source

Additional file 1: of Transcription factor E2F1 promotes EMT by regulating ZEB2 in small cell lung cancer

, 2017
Tingting Wang, Xufang Chen, Weiwei Qiao, Lijun Kong, Daqing Sun, Zunling Li   +5 more
openalex   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Emerging Role of Transcription Factor 19 (TCF19) in Inflammatory Disease and Cancer. [PDF]

Biomolecules
Li X, Jiang YF, Wang R, Yu J, Liu YJ, Dang YF, Yang GJ, Chen J.   +7 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

The transcription factor IRF8 drives tumor-specific exhaustion in CD8+ T cells. [PDF]

J Exp Med
Ongaro M, Thouenon R, Crespo I, Dumez A, Charmoy M, Roman Camacho E, Morel VJ, Cropp D, Desponds E, Zanette G, Wang YC, Vergili L, Tillé L, Di Resta I, Leblond MM, Corria Osorio J, Ho PC, Held W, Verdeil G.   +18 more
europepmc   +1 more source

A TCP domain transcription factor controls flower type specification along the radial axis of the Gerbera (Asteraceae) inflorescence

, 2008
Suvi Broholm, Sari Tähtiharju, Roosa A. E. Laitinen, Victor A. Albert, Teemu H. Teeri, Paula Elomaa   +5 more
openalex   +2 more sources

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Cleavage of the RNA polymerase II general transcription factor TFIIB tunes transcription during stress. [PDF]

Genes Dev
Gulyas L, Lari A, Shah SB, Glaunsinger BA.   +3 more
europepmc   +1 more source