Results 231 to 240 of about 15,541,955 (379)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

A GATA transcription factor OfGATA9 positively regulates flower size of sweet osmanthus. [PDF]

BMC Genomics
Wang Y, Peng L, Chen Q, Xia M, Ning A, Dong B, Zhong S, Deng J, Zhao H.   +8 more
europepmc   +1 more source

Characterization of a factor that can prevent random transcription of cloned rDNA and its probable relationship to poly(ADP-ribose) polymerase

, 1985
Rabinder N. Kurl, Samson T. Jacob
openalex   +1 more source

Regulatory T cell lineage specification by the forkhead transcription factor foxp3.

Immunity, 2005
J. Fontenot, J. P. Rasmussen, L. Williams, James L. Dooley, A. Farr, A. Rudensky   +5 more
semanticscholar   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Properties of Putative APSES Transcription Factor AfpA in <i>Aspergillus fumigatus</i>. [PDF]

J Fungi (Basel)
Choi YH, Lee MW, Shin KS.
europepmc   +1 more source

Internal deletion mutants ofXenopustranscription factor IIIA

, 1989
Jay S. Hanas, Roanna M. Littell, Chris J. Gaskins, Robert Zebrowski   +3 more
openalex   +1 more source

The master role of microphthalmia-associated transcription factor in melanocyte and melanoma biology.

Laboratory investigation; a journal of technical methods and pathology, 2017
A. Kawakami, D. Fisher
semanticscholar   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Promoter decoding of transcription factor dynamics

Molecular Systems Biology, 2013
Amie D Moody, Eric Batchelor
doaj   +1 more source