Results 51 to 60 of about 15,248,084 (403)
Dissection of a complex transcriptional response using genome‐wide transcriptional modelling
Molecular Systems Biology, 2009 Modern genomics technologies generate huge data sets creating a demand for systems level, experimentally verified, analysis techniques. We examined the transcriptional response to DNA damage in a human T cell line (MOLT4) using microarrays.
Martino Barenco +6 more
doaj +1 more source
Molecular Oncology, 2023 Transcription factors (TFs) are key players in the regulation of gene transcription in mammalian cells. Although high‐throughput screening can be used to identify differentially expressed genes between comparable groups, the precision of the ...
Fanchen Wang +7 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2022 The vertebrate nervous system exhibits dramatic variability in regenerative capacity across species and neuronal populations. For example, while the mammalian central nervous system (CNS) is limited in its regenerative capacity, the CNS of many other ...
Hilary R. Katz +4 more
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Identification of transcription factor binding sites using ATAC-seq
Genome Biology, 2018 Transposase-Accessible Chromatin followed by sequencing (ATAC-seq) is a simple protocol for detection of open chromatin. Computational footprinting, the search for regions with depletion of cleavage events due to transcription factor binding, is poorly ...
Zhijian Li +5 more
semanticscholar +1 more source
Smad transcription factors [PDF]
Genes & Development, 2005 Smad transcription factors lie at the core of one of the most versatile cytokine signaling pathways in metazoan biology—the transforming growth factor-β (TGFβ) pathway. Recent progress has shed light into the processes of Smad activation and deactivation, nucleocytoplasmic dynamics, and assembly of transcriptional complexes.
Joan Massagué +2 more
openaire +2 more sources
Determinants of transcription factor regulatory range
Nature Communications, 2020 Characterization of the distance over which TF binding influences gene expression is important for inferring target genes. Here the authors study this relationship using thousands of genomic data sets, finding two classes of TFs with distinct ranges of ...
Chen-Hao Chen +10 more
doaj +1 more source
Temperature-sensitive protein–DNA dimerizers [PDF]
, 2005 Programmable DNA-binding polyamides coupled to short peptides have led to the creation of synthetic artificial transcription factors. A hairpin polyamide-YPWM tetrapeptide conjugate facilitates the binding of a natural transcription factor Exd to an ...
Ansari, Aseem Z. +6 more
core +1 more source
Nucleic Acids Res., 2017 We present a major update of the HOCOMOCO collection that consists of patterns describing DNA binding specificities for human and mouse transcription factors.
I. Kulakovskiy +11 more
semanticscholar +1 more source
Transcription Factor KLF14 and Metabolic Syndrome
Frontiers in Cardiovascular Medicine, 2020 Metabolic syndrome (MetSyn) is a combination of metabolic abnormalities that lead to the development of cardiovascular disease (CVD) and Type 2 Diabetes (T2D).
Qianyi Yang, Mete Civelek, Mete Civelek
doaj +1 more source
Skeletal Muscle, 2021 Background The signal transducer and activator of transcription 6 (STAT6) transcription factor plays a vitally important role in immune cells, where it is activated mainly by interleukin-4 (IL-4).
Mitsutoshi Kurosaka +4 more
doaj +1 more source