Results 41 to 50 of about 2,521,760 (295)

Activating transcription factor 4-dependent hsa-miR-663a transcription mediates mTORC1/p70S6K1 signaling underleucine deprivation

Frontiers in Nutrition, 2022
The mechanistic target of rapamycin complex 1 (mTORC1) is involved in nutrient-induced signaling and is a master regulator of cell growth and metabolism.
Junki Yamamura, Sihui Ma, Huijuan Jia, Hisanori Kato   +3 more
doaj   +1 more source

Functional Profiling of Transcription Factor Genes in Neurospora crassa. [PDF]

, 2017
Regulation of gene expression by DNA-binding transcription factors is essential for proper control of growth and development in all organisms. In this study, we annotate and characterize growth and developmental phenotypes for transcription factor genes ...
Bekman, Thomas, Blahut, Johnathon, Borkovich, Katherine A, Cabrera, Ilva E, Carrera, Cristian, Carrillo, Alexander J, Chen, Vivian, Clark, Isaiah, Dietrich, Sarah, Fierro, Gerardo, Ganzen, Logan, Mei, Jennifer, Orellana, Jose, Prudhomme, Loren, Schacht, Patrick, Wise, Shelby, Yang, Kevin, Zhong, Hui   +17 more
core   +1 more source

NTH201, a Novel Class II KNOTTED1-Like Protein, Facilitates the Cell-to-Cell Movement of Tobacco mosaic virus in Tobacco

Molecular Plant-Microbe Interactions, 2008
NTH201, a novel class II KNOTTED1-like protein gene, was cloned from tobacco (Nicotiana tabacum cv. Xanthi) and its role in Tobacco mosaic virus (TMV) infection was analyzed. Virus-induced gene silencing of NTH201 caused a delay in viral RNA accumulation
Atsushi Yoshii, Takumi Shimizu, Akiko Yoshida, Koji Hamada, Keitaro Sakurai, Yasuyuki Yamaji, Masashi Suzuki, Shigetou Namba, Tadaaki Hibi   +8 more
doaj   +1 more source

Determinants of transcription factor regulatory range

Nature Communications, 2020
Characterization of the distance over which TF binding influences gene expression is important for inferring target genes. Here the authors study this relationship using thousands of genomic data sets, finding two classes of TFs with distinct ranges of ...
Chen-Hao Chen, Rongbin Zheng, Collin Tokheim, Xin Dong, Jingyu Fan, Changxin Wan, Qin Tang, Myles Brown, Jun S. Liu, Clifford A. Meyer, X. Shirley Liu   +10 more
doaj   +1 more source

Architecture of Pol II(G) and molecular mechanism of transcription regulation by Gdown1. [PDF]

, 2018
Tight binding of Gdown1 represses RNA polymerase II (Pol II) function in a manner that is reversed by Mediator, but the structural basis of these processes is unclear.
A Leitner, A Rohou, A Sali, AL Gnatt, Andrej Sali, BL Allen, Brian T. Chait, C Bernecky, C Plaschka, C Suloway, D Kostrewa, D Russel, EF Pettersen, F Yue, Francisco J. Asturias, G Pan, GC Lander, H Ueda, J Eichner, J Fernandez-Martinez, J Sun, L Fagerberg, M Jishage, MA Cevher, Miki Jishage, P Emsley, PB Rosenthal, PV Afonine, R Algret, RG Roeder, Robert G. Roeder, S Grunberg, S Malik, S Malik, S Malik, S Malik, S Sainsbury, S Sainsbury, S Tan, Sai J. Ganesan, SH Scheres, SH Scheres, T Kanesaki, VB Chen, W Muhlbacher, Wei-Yi Chen, X Hu, X Li, XC Bai, Xiaodi Yu, Y He, Y He, Y Shi, Y Shi, Yi Shi, YM Wu, ZA Chen   +56 more
core   +2 more sources

Simple SVM based whole-genome segmentation [PDF]

, 2009
We present a support vector machine (SVM) based framework for DNA segmentation into binary classes. Two applications are explored: transcription start site prediction and transcription factor binding prediction.
Adam Kowalczyk, Geoff Macintyre, Izhak Haviv, Justin Bedo   +3 more
core   +2 more sources

Transcription factor mutations in myelodysplastic/myeloproliferative neoplasms

Haematologica, 2010
Background Aberrant activation of tyrosine kinases, caused by either mutation or gene fusion, is of major importance for the development of many hematologic malignancies, particularly myeloproliferative neoplasms.
Thomas Ernst, Andrew Chase, Katerina Zoi, Katherine Waghorn, Claire Hidalgo-Curtis, Joannah Score, Amy Jones, Francis Grand, Andreas Reiter, Andreas Hochhaus, Nicholas C.P. Cross   +10 more
doaj   +1 more source

Transcription factor dynamics

Microbiology, 2008
Gene expression is a fundamental process that is highly conserved from humans to bacteria. The first step in gene expression, transcription, is performed by structurally conserved DNA-dependent RNA polymerases (RNAPs), which results in the synthesis of an RNA molecule from a DNA template.
Lewis, P. J., Doherty, G. P., Clarke, J.
openaire   +4 more sources

Identification of transcription factor binding sites in promoter databases [PDF]

, 2011
Transcription factors (TFs) are the proteins which regulates the expression of their target genes either in a positive or negative manner. TFs realize this task by binding to a specific DNA sequence contained in promoter regions, via their DNA binding ...
Dağ, Uğur, Durası, İlknur Melis, Erdoğan, Burcu, Güngör, Burcu Bakır, Kurnaz, Işıl Aksan, Sezerman, Uğur   +5 more
core   +1 more source

A patient‐derived explant (PDE) model of hormone‐dependent cancer

Molecular Oncology, 2018
Breast and prostate cancer research to date has largely been predicated on the use of cell lines in vitro or in vivo. These limitations have led to the development of more clinically relevant models, such as organoids or murine xenografts that utilize ...
Margaret M. Centenera, Theresa E. Hickey, Shalini Jindal, Natalie K. Ryan, Preethi Ravindranathan, Hisham Mohammed, Jessica L. Robinson, Matthew J. Schiewer, Shihong Ma, Payal Kapur, Peter D. Sutherland, Clive E. Hoffmann, Claus G. Roehrborn, Leonard G. Gomella, Jason S. Carroll, Stephen N. Birrell, Karen E. Knudsen, Ganesh V. Raj, Lisa M. Butler, Wayne D. Tilley   +19 more
doaj   +1 more source