Results 21 to 30 of about 1,606,785 (217)
Determinants of transcription factor regulatory range
Nature Communications, 2020 Characterization of the distance over which TF binding influences gene expression is important for inferring target genes. Here the authors study this relationship using thousands of genomic data sets, finding two classes of TFs with distinct ranges of ...
Chen-Hao Chen +10 more
doaj +1 more source
Transcription factor mutations in myelodysplastic/myeloproliferative neoplasms
Haematologica, 2010 Background Aberrant activation of tyrosine kinases, caused by either mutation or gene fusion, is of major importance for the development of many hematologic malignancies, particularly myeloproliferative neoplasms.
Thomas Ernst +10 more
doaj +1 more source
A patient‐derived explant (PDE) model of hormone‐dependent cancer
Molecular Oncology, 2018 Breast and prostate cancer research to date has largely been predicated on the use of cell lines in vitro or in vivo. These limitations have led to the development of more clinically relevant models, such as organoids or murine xenografts that utilize ...
Margaret M. Centenera +19 more
doaj +1 more source
Transcription Factor Networks in Drosophila melanogaster
Cell Reports, 2014 Specific cellular fates and functions depend on differential gene expression, which occurs primarily at the transcriptional level and is controlled by complex regulatory networks of transcription factors (TFs).
David Y. Rhee +12 more
doaj +1 more source
Pleiotropic functions for transcription factor zscan10.
PLoS ONE, 2014 The transcription factor Zscan10 had been attributed a role as a pluripotency factor in embryonic stem cells based on its interaction with Oct4 and Sox2 in in vitro assays.
Petra Kraus +35 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Purpose To explore caregivers' experiences and perceptions of the nutritional challenges faced by children and adolescents undergoing cancer treatment, including oral intake and the use of nutritional support. Methods This was a qualitative study based on focus groups with parents and caregivers at a Brazilian pediatric oncology hospital ...
Danyelle Apparecida Balsamão Marques +5 more
wiley +1 more source
Dissection of a complex transcriptional response using genome‐wide transcriptional modelling
Molecular Systems Biology, 2009 Modern genomics technologies generate huge data sets creating a demand for systems level, experimentally verified, analysis techniques. We examined the transcriptional response to DNA damage in a human T cell line (MOLT4) using microarrays.
Martino Barenco +6 more
doaj +1 more source
The Sox2 transcription factor binds RNA
Nature Communications, 2020 Some transcription factors have been proposed to functionally interact with RNA to facilitate proper regulation of gene expression. Here the authors demonstrate that human Sox2 interact directly and with high affinity to RNAs through its HMG DNA-binding ...
Zachariah E. Holmes +6 more
doaj +1 more source
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Introduction Hyperlipidemia is a major risk factor for atherosclerotic cardiovascular disease (ASCVD). Although statins are the cornerstone of lipid‐lowering therapy, their use may be limited in some patients by adverse effects. This study evaluated the possible impact of non‐drug treatment using double‐filtration plasmapheresis (DFPP) on CD14+
Yun Cheng +3 more
wiley +1 more source
Pea3 transcription factor promotes neurite outgrowth
Frontiers in Molecular Neuroscience, 2014 Pea3 subfamily of ETS transcription factors consist of three major proteins, Pea3, ERM and ER81. Although important for many different tissues that exhibit branching morphogenesis, the function of Pea3 family in nervous system development and ...
BASAK eKANDEMIR +8 more
doaj +1 more source