Results 21 to 30 of about 2,521,760 (295)

Sequence Dependence of Transcription Factor-Mediated DNA Looping [PDF]

, 2012
DNA is subject to large deformations in a wide range of biological processes. Two key examples illustrate how such deformations influence the readout of the genetic information: the sequestering of eukaryotic genes by nucleosomes, and DNA looping in ...
Barry, Bellomy, Bellomy, Brenowitz, Butler, Chen, Chen, Cloutier, Cloutier, Drew, Du, Echols, Edelman, Finzi, Frank, Garcia, Geggier, Han, Hirsh, Hogan, Hsieh, Jacobson, Krämer, Lewis, Lowary, Luger, Luijsterburg, Martin Lindén, Matthews, Mehta, Milstein, Morgan, Müller, Newman, Normanno, Oehler, Olson, Peters, Plischke, Ptashne, Rippe, Rob Phillips, Rutkauskas, Saiz, Schafer, Schleif, Segall, Shimada, Stephanie Johnson, Swigon, Tolhuis, Towles, Vanzi, Villa, Watson, Whitson, Whitson, Widom, Wong, Xu, Yin, Zhan, Zhang   +62 more
core   +4 more sources

Transforming a transcription factor

eLife, 2018
A transcription factor that regulates skeleton formation in sea urchin embryos has evolved a new domain that is essential for this process.
Robert D Burke
doaj   +1 more source

Structural fingerprints of transcription factor binding site regions [PDF]

, 2009
Fourier transforms are a powerful tool in the prediction of DNA sequence properties, such as the presence/absence of codons. We have previously compiled a database of the structural properties of all 32,896 unique DNA octamers.
Christopher Hunter, Collins, Eleanor J. Gardiner, Fickett, Kampa, Packer, Peter Willett, Tiwari, Waterston   +8 more
core   +2 more sources

A preliminary computational outputs versus experimental results: Application of sTRAP, a biophysical tool for the analysis of SNPs of transcription factor‐binding sites

Molecular Genetics & Genomic Medicine, 2020
Background In the human genome, the transcription factors (TFs) and transcription factor‐binding sites (TFBSs) network has a great regulatory function in the biological pathways.
Shirin Moradifard, Reza Saghiri, Parastoo Ehsani, Fatemeh Mirkhani, Mina Ebrahimi‐Rad   +4 more
doaj   +1 more source

Human transcription factor protein interaction networks

Nature Communications, 2022
Transcription factors (TFs) interact with several other proteins in the process of transcriptional regulation. Here the authors identify 6703 and 1536 protein–protein interactions for 109 different human TFs through BioID and AP-MS analyses, respectively.
Helka Göös, Matias Kinnunen, Kari Salokas, Zenglai Tan, Xiaonan Liu, Leena Yadav, Qin Zhang, Gong-Hong Wei, Markku Varjosalo   +8 more
doaj   +1 more source

Transcription factor EB regulates cardiovascular homeostasis

EBioMedicine, 2021
Cardiovascular diseases (CVDs) are the leading cause of death and a major cause of disability globally. Transcription factor EB (TFEB), as a member of the microphthalmia transcription factor (MITF) family, has been demonstrated to be a master regulator ...
Haocheng Lu, Jinjian Sun, Milton H. Hamblin, Y. Eugene Chen, Yanbo Fan   +4 more
doaj   +1 more source

Re-utilization of a transcription factor

eLife, 2016
The temporal transcription factor Krüppel has a dual role in the development of neurons.
Filipe Pinto-Teixeira, Claude Desplan
doaj   +1 more source

Transcription Factor KLF14 and Metabolic Syndrome

Frontiers in Cardiovascular Medicine, 2020
Metabolic syndrome (MetSyn) is a combination of metabolic abnormalities that lead to the development of cardiovascular disease (CVD) and Type 2 Diabetes (T2D).
Qianyi Yang, Mete Civelek, Mete Civelek
doaj   +1 more source

Stochastic model of transcription factor-regulated gene expression [PDF]

, 2006
We consider a stochastic model of transcription factor (TF)-regulated gene expression. The model describes two genes: Gene A and Gene B which synthesize the TFs and the target gene proteins respectively.
Alberts B, Bose I, Ferrer J, Fodde R, Ghosh B, Hume D A, Indrani Bose, Karmakar R, Kepler T B, Rajesh Karmakar, Santarosa M, Scott M   +11 more
core   +2 more sources

Optimization of Transcription Factor Genetic Circuits

Biology, 2022
Transcription factors (TFs) affect the production of mRNAs. In essence, the TFs form a large computational network that controls many aspects of cellular function. This article introduces a computational method to optimize TF networks. The method extends
Steven A. Frank
doaj   +1 more source