Results 11 to 20 of about 1,606,785 (217)

A Transcription Factor-Centric View of Transcription Regulation [PDF]

Biology
Transcription is arguably the most critical regulatory step in gene expression. In eukaryotes, a promoter is necessary for transcription, but it alone often does not lead to significant gene transcription.
Jing He, Jiahui Chi, Siqian Feng
doaj   +2 more sources

MAFF is a transcription factor that regulates contraction-induced skeletal muscle transcription [PDF]

Life Science Alliance
Acute exercise robustly induces MAFF in human and mouse skeletal muscle, and loss of Maff in C2C12 myotubes impairs myogenic fusion and attenuates contraction-induced transcriptional programs.
Taku Fukushima, Taiju Fujioka, Satoru Masubuchi, Iori Sakakibara   +3 more
doaj   +2 more sources

Transcription factor condensates and signaling driven transcription

Nucleus, 2023
Transcription Factor (TF) condensates are a heterogenous mix of RNA, DNA, and multiple co-factor proteins capable of modulating the transcriptional response of the cell.
Rajat Mann, Dimple Notani
doaj   +1 more source

The ets-related transcription factor GABP directs bidirectional transcription. [PDF]

PLoS Genetics, 2007
Approximately 10% of genes in the human genome are distributed such that their transcription start sites are located less than 1 kb apart on opposite strands. These divergent gene pairs have a single intergenic segment of DNA, which in some cases appears
Patrick J Collins, Yuya Kobayashi, Loan Nguyen, Nathan D Trinklein, Richard M Myers   +4 more
doaj   +1 more source

KLF4 transcription factor in tumorigenesis

Cell Death Discovery, 2023
Krüppel-like transcriptional factor is important in maintaining cellular functions. Deletion of Krüppel-like transcriptional factor usually causes abnormal embryonic development and even embryonic death.
Zhihong He, Jie He, Keping Xie
doaj   +1 more source

Understanding variation in transcription factor binding by modeling transcription factor genome-epigenome interactions.

PLoS Computational Biology, 2013
Despite explosive growth in genomic datasets, the methods for studying epigenomic mechanisms of gene regulation remain primitive. Here we present a model-based approach to systematically analyze the epigenomic functions in modulating transcription factor-
Chieh-Chun Chen, Shu Xiao, Dan Xie, Xiaoyi Cao, Chun-Xiao Song, Ting Wang, Chuan He, Sheng Zhong   +7 more
doaj   +1 more source

Transforming a transcription factor

eLife, 2018
A transcription factor that regulates skeleton formation in sea urchin embryos has evolved a new domain that is essential for this process.
Robert D Burke
doaj   +1 more source

Widespread Strain-Specific Distinctions in Chromosomal Binding Dynamics of a Highly Conserved Escherichia coli Transcription Factor

mBio, 2020
Bacterial gene regulation is governed by often hundreds of transcription factors (TFs) that bind directly to targets on the chromosome. Global studies of TFs usually make assumptions that regulatory targets within model strains will be conserved between ...
James P. R. Connolly, Nicky O’Boyle, Andrew J. Roe   +2 more
doaj   +1 more source

A preliminary computational outputs versus experimental results: Application of sTRAP, a biophysical tool for the analysis of SNPs of transcription factor‐binding sites

Molecular Genetics & Genomic Medicine, 2020
Background In the human genome, the transcription factors (TFs) and transcription factor‐binding sites (TFBSs) network has a great regulatory function in the biological pathways.
Shirin Moradifard, Reza Saghiri, Parastoo Ehsani, Fatemeh Mirkhani, Mina Ebrahimi‐Rad   +4 more
doaj   +1 more source

Re-utilization of a transcription factor

eLife, 2016
The temporal transcription factor Krüppel has a dual role in the development of neurons.
Filipe Pinto-Teixeira, Claude Desplan
doaj   +1 more source