Results 71 to 80 of about 15,248,084 (403)
FEBS Letters, EarlyView.Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi +3 more
wiley +1 more source
Transcription factors in fungi [PDF]
FEMS Microbiology Letters, 2008 Transcription factors (TFs) orchestrate gene expression control of a cell and, in many respects, their repertoire determines the life and functionality of the cell. For a better understanding of their regulatory mechanisms, it is essential to know the entire repertoire of TFs of a species.
openaire +3 more sources
Transcription Factors in Cancer
International Journal of Molecular Sciences, 2022 This Special Issue comprises three original studies and five review articles [...]
Tomasz Wilanowski, Sebastian Dworkin
openaire +2 more sources
Dynamic Transformations of Genome-wide Epigenetic Marking and Transcriptional Control Establish T Cell Identity [PDF]
, 2012 T cell development comprises a stepwise process of commitment from a multipotent precursor. To define molecular mechanisms controlling this progression, we probed five stages spanning the commitment process using RNA-seq and ChIP-seq to track genome-wide
Mortazavi, Ali +4 more
core +2 more sources
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
A mouse tissue transcription factor atlas
Nature Communications, 2017 While we have abundant data for transcription factor (TF) binding sites and TF expression at the mRNA level, our knowledge of TFs at the protein level and their DNA-binding activities is sparser.
Quan Zhou +10 more
doaj +1 more source
Biophysical Fitness Landscapes for Transcription Factor Binding Sites
, 2013 Evolutionary trajectories and phenotypic states available to cell populations are ultimately dictated by intermolecular interactions between DNA, RNA, proteins, and other molecular species.
Haldane, Allan +2 more
core +3 more sources
Identification of transcription factor binding sites in promoter databases [PDF]
, 2011 Transcription factors (TFs) are the proteins which regulates the expression of their target genes either in a positive or negative manner. TFs realize this task by binding to a specific DNA sequence contained in promoter regions, via their DNA binding ...
Dağ, Uğur +5 more
core +1 more source
Visualizing transcription factor dynamics in living cells
Journal of Cell Biology, 2018 Liu and Tjian review how superresolution and live-cell imaging are providing new insights into transcription factor dynamics and genome organization.
Zhe J. Liu, R. Tjian
semanticscholar +1 more source
FEBS Letters, EarlyView.Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa +8 more
wiley +1 more source