Results 71 to 80 of about 2,601,708 (287)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

A novel compartment, the 'subqpical stem' of the aerial hyphae, is the location of a sigN-dependent, developmentally distinct transcription in Streptomyces coelicolor. [PDF]

, 2007
Streptomyces coelicolor has nine SigB-like RNA polymerase sigma factors, several of them implicated in morphological differentiation and/or responses to different stresses. One of the nine, SigN, is the focus of this article.
Bignell D.R., Boylan S.A., Champness W.C., Delic V., Errington J., Flardh K., Haldenwang W.G., Homerova D., Hopwood D.A., Kalman S., Karmazyn-Campelli C., Kelemen G.H., Kieser T., Lee E.J., Masuda E.S., Mendez C., Merrick M.J., Nodwell J.R., Price C.W., Sun J., Wildermuth H., Willey J.   +21 more
core   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Wide-Scale Analysis of Human Functional Transcription Factor Binding Reveals a Strong Bias towards the Transcription Start Site [PDF]

, 2007
We introduce a novel method to screen the promoters of a set of genes with shared biological function, against a precompiled library of motifs, and find those motifs which are statistically over-represented in the gene set.
A Ambesi-Impiombato, A Blais, A Eto, A Subramanian, AE Kel, AG Clark, AL Lam, AM McGuire, Anat Reiner, Assif Yitzhaky, B Ren, C Kimura-Yoshida, C Plessy, C Yang, CT Harbison, D Pfeifer, D Wang, DB Allison, E Emberly, E Segal, Eytan Domany, FP Roth, GC Pipes, GC Yuan, GQ Yao, GZ Hertz, H Li, H Lodish, J Zheng, JD Hughes, JL DeRisi, JQ Ling, K Frech, K Quandt, KD MacIsaac, L Amir-Zilberstein, L Elnitski, L Marino-Ramirez, L McCue, M Ashburner, M Kellis, M Milyavsky, MA Nobrega, Mark Koudritsky, MC Frith, ML Howard, ML Whitfield, N Rajewsky, Or Zuk, P Carninci, P Carninci, P Cliften, PM Haverty, PR Buckland, R Elkon, R Liu, R Sharan, Ran Brosh, S Aerts, S Rashi-Elkeles, S Tavazoie, SJ Cooper, SJ Ho Sui, Sui Huang, U Gerland, Varda Rotter, WW Wasserman, X Xie, Y Barash, Y Benjamini, Y Benjamini, Y Tabach, Yossi Buganim, Yuval Tabach, Z Wang   +74 more
core   +5 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Transcription Factor-DNA Binding Via Machine Learning Ensembles [PDF]

, 2018
We present ensemble methods in a machine learning (ML) framework combining predictions from five known motif/binding site exploration algorithms. For a given TF the ensemble starts with position weight matrices (PWM's) for the motif, collected from the ...
DeLisi, Charles, Fan, Yue, Kon, Mark
core  

Protein Evolution in Yeast Transcription Factor Subnetworks [PDF]

, 2010
When averaged over the full yeast protein–protein interaction and transcriptional regulatory networks, protein hubs with many interaction partners or regulators tend to evolve significantly more slowly due to increased negative selection. However, genome-
Franzosa, Eric A., Wang, Yong, Xia, Yu, Zhang, Xiang-Sun   +3 more
core   +3 more sources

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

A mouse tissue transcription factor atlas

Nature Communications, 2017
While we have abundant data for transcription factor (TF) binding sites and TF expression at the mRNA level, our knowledge of TFs at the protein level and their DNA-binding activities is sparser.
Quan Zhou, Mingwei Liu, Xia Xia, Tongqing Gong, Jinwen Feng, Wanlin Liu, Yang Liu, Bei Zhen, Yi Wang, Chen Ding, Jun Qin   +10 more
doaj   +1 more source

MicroRNA-631 deriving from bone marrow mesenchymal stem cell exosomes facilitates the malignant behavior of non-small cell lung cancer via modulating the E2F family of transcription factor 2/phosphatidylinositol 3‐kinase/Akt signaling pathway [PDF]

, 2022
Hong Lv, Jing Yu, Hao Zhang, Xingjia Qian, Qian Wang, Bing Lu, Yifeng Sun   +6 more
openalex   +1 more source