Results 221 to 230 of about 4,631,251 (249)

Optimized Genome‐Wide Profiling of Centromeric Chromatin Complexes by ChIP‐seq

Current Protocols, Volume 6, Issue 10, October 2026.
Abstract Centromeres are specialized chromosomal regions essential for faithful chromosome segregation and genome stability. Their highly repetitive DNA composition and epigenetically defined chromatin state present significant challenges for genome‐wide profiling approaches such as chromatin immunoprecipitation followed by sequencing (ChIP‐seq ...
Alessia Daponte, Rachel Schwope, Caterina Manzari, Lucia Trisolini, Francesca Antonacci, Michele Morgante, Mario Ventura, Glennis A. Logsdon, Claudia R. Catacchio   +8 more
wiley   +1 more source

Lactate metabolism and protein lactylation in programmed cell death: From novel mechanism to therapeutic strategies in human diseases

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
This review highlights protein lactylation as a metabolic‐epigenetic regulator linking lactate reprogramming to programmed cell death. By modulating histone and non‐histone targets, lactylation reshapes cell fate decisions and represents a promising biomarker and therapeutic target in human diseases.
Yue Chen, Xiwen Wang, Xiuping Wang, Na Lin, Wenjie Wang, Ruiqi Fu, Yutong Wu, Yi Liu, Hengwei Liu   +8 more
wiley   +1 more source

Predicting Relevant Microglia‐Associated Cell–Cell Communication Pathways in Alzheimer's Disease: A Role for SPP1

Glia, Volume 74, Issue 10, October 2026.
We used CellChat to infer altered cell–cell communication in Alzheimer's disease Microglia signal to each other via SPP1 in Alzheimer's disease. SPP1‐expressing microglia are present around amyloid‐β plaques. ABSTRACT Microglia play a key role in the pathophysiology of Alzheimer's Disease (AD) and their increased heterogeneity likely affects disease ...
Janssen M. Kotah, Marina Trombetta Lima, Esmée C. Dragt, Asimenia Voulgaroglou, Nieske Brouwer, Inge R. Holtman, Susanne M. Kooistra, Bart J. L. Eggen   +7 more
wiley   +1 more source

Crosstalk Between Parkinson's Disease and Colorectal Cancer: Genetic Mechanisms, Gut Microbiota, and Therapeutic Insights

Health Care Science, Volume 5, Issue 5, Page 495-513, October 2026.
This review elucidates the crosstalk between Parkinson's disease and colorectal cancer, driven by shared genetics (PRKN, PINK1, DJ‐1) involving oxidative stress, cell cycle regulation, and inflammation. It identifies the gut microbiota—via functional amyloids and short‐chain fatty acids (SCFAs)—as a mechanistic bridge, offering insights for dual ...
Jiacheng Ying, Zhengyuan Fang, Cheng Zhang, Xu Liu, Jianzhi Cui, Zezhi Li, Jiayin Tang   +6 more
wiley   +1 more source

Towards System Changes: Experiences of General Practitioners and Nurses in Facilitating Appointments and Referrals for Africans from Refugee Backgrounds in Australia

Health Promotion Journal of Australia, Volume 37, Issue 4, October 2026.
ABSTRACT Objective This study explored the experiences of general practitioners (GPs) and nurses working in specialised refugee health services when facilitating specialist hospital appointments and referrals for Africans from refugee backgrounds in Australia. Methods An exploratory‐descriptive, qualitative study was conducted.
Prince Peprah, Emmanuel Brenyah Adomako, Dipti Zachariah, David Ajak Ajang   +3 more
wiley   +1 more source

C1qc Mediates Blood–Brain Barrier Disruption in a Mouse Model of Intracerebral Haemorrhage Through Microglia‐Derived Migrasomes

Journal of Extracellular Vesicles, Volume 15, Issue 10, October 2026.
Microglia‐derived migrasomes induce vascular endothelial pyroptosis through C1qc delivery, uncovering a novel mechanism of blood–brain barrier (BBB) disruption after intracerebral haemorrhage (ICH) and proposing a novel therapeutic strategy targeting extracellular vesicles (EVs).
Mengyuan Li, Zhihua Li, Dengpan Song, Fang Wang, Mengzhao Feng, Chi‐Tai Yeh, Tingting Zhai, Menghan Deng, Yanyan Sun, Junyang Wang, Xuemei Chen, Yating Wang, Qiong Yang, Moxin Wu, Xiaoping Yin, Junmin Wang, Jian Wang, Fuyou Guo   +17 more
wiley   +1 more source

Transcription Factor EB Overexpression through Glial Fibrillary Acidic Protein Promoter Disrupts Neuronal Lamination by Dysregulating Neurogenesis during Embryonic Development.

Dev Neurosci
Wang L, Cao J, Chen H, Ma Y, Zhang Y, Su X, Jing Y, Wang Y.   +7 more
europepmc   +1 more source

The Neuroprotective Effects of Curcumin Nanoparticles on The Cerebral Ischemia-Reperfusion Injury in The Rats-The Roles of The Protein Kinase RNA-Like ER Kinase/Extracellular Signal-Regulated Kinase and Transcription Factor EB proteins. [PDF]

Cell J
Saghari Y, Movahedi M, Tebianian M, Entezari M.   +3 more
europepmc   +1 more source

The thrombopoietin receptor S264F mutant drives MPN with marrow fibrosis through a dual mechanism

HemaSphere, Volume 10, Issue 10, October 2026.
Charlotte Lees, Emile Brandt, Emmanuel Dutranoix, Gabriel Levy, Bogdan I. Iorga, Hosuk Ryou, Jens Rittscher, Daniel Royston, Stefan N. Constantinescu, Adam J. Mead   +9 more
wiley   +1 more source

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Roles of transposable elements in the regulation of mammalian transcription

Nature Reviews Molecular Cell Biology, 2022
Julius A Judd, Joanna Wysocka, Cédric Feschotte   +2 more
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