Results 141 to 150 of about 36,830 (233)

Transcriptional induction of SOX9 by NF-κB family member RelA in chondrogenic cells

, 2009
SummaryObjectiveAlthough SOX9 is a key molecule for chondrogenic differentiation, little is known about the upstream signal. The present study attempted to identify transcription factors to induce SOX9 expression and examined the mechanism ...
Nakamura, K., Higashikawa, A., Kawaguchi, H., Ushita, M., Saito, T., Chung, U., Ikeda, T., Ogata, N., Yano, F.   +8 more
core   +1 more source

Polygonati Rhizoma Attenuates Oxidative Stress‐Induced Senescence in Periodontal Ligament Stem Cells

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Network pharmacology identified the potential targets and pathways of Polygonati Rhizoma (PR) against aging‐related periodontitis through PPI, GO/KEGG enrichment, and molecular docking. Experimental validation in a D‐galactose‐induced senescence model of periodontal ligament stem cells showed that PR‐medicated serum attenuated cellular senescence and ...
Xinran Feng, Ying An, Fanfan Hou, Qian Guo, Shanshan Cai, Hongbin Xu, Youfu He   +6 more
wiley   +1 more source

Foodborne toxin Aflatoxin B1 induced glomerular podocyte inflammation through proteolysis of RelA, downregulation of miR-9 and CXCR4/TXNIP/NLRP3 pathway

Food Science and Human Wellness
Aflatoxin B1 (AFB1) is a naturally-occurring mycotoxin and recognized as the most toxic foodborne toxin, particularly causing damages to kidney. Glomerular podocytes are terminally differentiated epithelial cells.
Jie Zhang, Shuang Yang, Baocai Xu, Zihui Qin, Xinyi Guo, Ben Wei, Qinghua Wu, Kamil Kuca, Tushuai Li, Wenda Wu   +9 more
doaj   +1 more source

Hypoxia induces rapid, STAT3 and ROS dependent, mitochondrial translocation of RelA(p65) and IκBα [PDF]

, 2019
\ua9 2019 The Author(s).The nuclear factor-κB (NF-κB) family of transcription factors can directly or indirectly regulate many important areas of biology, including immunity, inflammation and cell survival.
Perkins ND, Ivanova IG
core  

Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells.

, 1997
The pathogenesis and etiology of Hodgkin's disease, a common human malignant lymphoma, is still unresolved. As a unique characteristic, we have identified constitutive activation of the transcription factor nuclear factor (NF)-kappaB p50-RelA in Hodgkin ...
Emmerich, F., Krappmann, D., Arnold, W., W Arnold, A Greiner, Royer, H.D., Doerken, B., D Krappmann, H D Royer, M Y Mapara, B Dörken, K Bommert, Grinstein, E., Scheidereit, C., Greiner, A., R C Bargou, F Emmerich, Bommert, K., C Scheidereit, Mapara, M.Y., Bargou, R.C., E Grinstein   +21 more
core   +1 more source

The Rising Burden of Osteosarcopenia in Older Adults: A Narrative Review of Pathophysiology, Diagnostic Challenges, and Therapeutic Perspectives

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aims Osteosarcopenia, defined as the coexistence of osteoporosis and sarcopenia, is an emerging geriatric syndrome linked to the musculoskeletal decline associated with aging. It is correlated with an increased risk of falls, fractures, disability, and mortality.
Javeria Taj, Rabia Zafar, Joshua Ekouo, Ayesha Junaid, Dujardin Makeda, Kinza Latif, Hermann Yokolo   +6 more
wiley   +1 more source

Engineered Bacillus subtilis regulates intestinal barrier in ETEC K88‐infected piglets and modulates miR‐1250‐5p/NFκB pathway in IPEC‐J2

iMetaOmics, Volume 3, Issue 2, June 2026.
Upon enterotoxigenic Escherichia coli (ETEC) K88 infection, intestinal barrier function is disrupted with compromised tight junctions, accompanied by an exacerbated inflammatory response, proliferation of pathogenic Escherichia, and depletion of beneficial Lactobacillus paralimentarius.
Chaoyue Wen, Hong Zhang, Qiuping Guo, Yehui Duan, Sisi Chen, Mengmeng Han, Leli Wang, Le Huang, Yuankun Deng, Fengna Li, Yizhen Wang, Mingliang Jin   +11 more
wiley   +1 more source

Mutational analysis of the transcription activation domain of RelA: identification of a highly synergistic minimal acidic activation module

, 1994
The potent C-terminal activation domain of the RelA(p65) subunit of the cellular transcription factor NF-KB is shown to contain several discrete acidic activation modules.
Bryan R. Cullen, Wade S. Blair, Hal P. Bogerd, Steven J. Madore   +3 more
core  

Chronic Low‐Dose Unsymmetrical Dimethylhydrazine Exposure in Rats: Multiorgan Mechanisms and Biomarker Identification

Journal of Applied Toxicology, Volume 46, Issue 6, Page 1987-2002, June 2026.
ABSTRACT Unsymmetrical dimethylhydrazine (UDMH), a highly toxic rocket propellant with known multiorgan effects, requires urgent characterization of its chronic low‐dose toxicity. Using an integrated approach including exploratory transcriptomics (n = 3/group) and metabolomic (n = 4/group) approaches in male Sprague–Dawley rats exposed to high‐dose ...
Fuzhou Liu, Bing Liu, Keli Wang, Xiaoyu Wang, Zhen Sun, Xiaojuan Pan, Zengming Zhao   +6 more
wiley   +1 more source

Enterococcus faecalis Extracellular Vesicles Deliver the Bacterial GTPase Obg to Hijack mTOR Signalling in Hepatocellular Carcinoma

Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
E. faecalis is enriched in HCC tissue and can promote liver tumourigenesis by activating mTOR signalling pathway. Obg derived from E. faecalis extracellular vesicles (EVs) is a GTPase physically interacts with mTOR, and acts as an interkingdom activator of mTOR. EF‐Obg expression level in HCC tissue correlates with poor prognosis in HCC patients.
Ning Ma, Xiaoshan Xie, Jiarui Wang, Zhikai Zheng, Huilin Jin, Xijie Chen, Xiaoling Huang, Haidan Luo, Yue Wei, Qihao Pan, Boyu Zhang, Jiaying Zheng, Peng Zhang, Fenghai Yu, Xue Liu, Zhi‐Min Zhang, Zhongguo Zhou, Xiangqi Meng, Mong‐Hong Lee   +18 more
wiley   +1 more source