Results 121 to 130 of about 36,830 (233)

Identification of a Selective RelA Inhibitor Based on DSE-FRET Screening Methods

, 2020
Nuclear factor-κB (NF-κB) is an important transcription factor involved in various biological functions, including tumorigenesis. Hence, NF-κB has attracted attention as a target factor for cancer treatment, leading to the development ...
Hidetoshi Tahara, Ashutosh Kumar, Akihiro Ito, Hiroyuki Osada, Minoru Yoshida, Go Fujita, Ryou-u Takahashi, Kam Y. J. Zhang, Takuya Yamamoto, Yoshitomo Shiroma   +9 more
core   +1 more source

Polygonatum cyrtonema Polysaccharides‐Derived Metabolic Meta Alleviates ALD via a Gut–Liver Axis–Mediated, Bifidobacterium pseudolongum–Driven Suppression of the AA Metabolism–MAPK Signaling Network

Food Frontiers, Volume 7, Issue 4, July 2026.
This study demonstrates that the hepatoprotective effect of Polygonatum cyrtonema polysaccharide (PCP) is mediated by its gut microbiota‐derived metabolome, which enriches Bifidobacterium pseudolongum, suppresses the gut–liver axis of AA metabolism, and inhibits hepatic MAPK signaling. ABSTRACT Polygonatum cyrtonema, a traditional Chinese medicinal and
Xingcai Gao, Qing Zhou, Baoting Liu, Jun Li, Jianhua Xie, Yi Chen, Chenxu Gong, Xiaobo Hu, Qiang Yu   +8 more
wiley   +1 more source

Deciphering the Therapeutic and Preventive Potential of Dietary Tannins in Osteosarcoma: A Multi‐Omics Approach Targeting TGFA and Immune Microenvironment Remodeling

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
Dietary tannin‐associated molecular programs converge on a TGFA‐centered regulatory axis that governs osteosarcoma progression and immune remodeling. Multi‐omics integration combined with machine learning identifies a tannin‐related risk score (TRR) that stratifies tumor aggressiveness and immune landscape heterogeneity.
Ge Yunling, Xu Jietao, Xiao He, Zhao Tingxiao, Lv Jun, Zhou Hong, Qian Jiawei, Wang Xijun, Kang Yao   +8 more
wiley   +1 more source

PVT1 lincRNA signals an androgen‐dependent transcriptional activation program of oncogenes in prostate cancer cells

International Journal of Cancer, Volume 159, Issue 1, Page 144-158, 1 July 2026.
What's New? Unraveling the networks that regulate androgen receptor (AR) function is critical to better understanding prostate cancer development and progression. Of particular interest in this regard is the long non‐coding RNA PVT1, which regulates gene expression in cancer and is upregulated in prostate tumors.
Maria Gabriela Berzoti‐Coelho, Fabio Nunes de Mello, Ana Carolina Tahira, Gabriel Nakanishi Fortes, Agatha Fischer‐Carvalho, Pedro Jardim Poli, Murilo Sena Amaral, Sergio Verjovski‐Almeida   +7 more
wiley   +1 more source

Teamwork of clustered low-affinity κB sites and accessory factors regulates transcriptional strength of NF-κB RelA dimers

Nucleic Acids Research
Abstract Non-consensus binding sites of transcription factors (TFs) are often observed within the regulatory elements of genes; however, their effect on transcriptional strength is unclear. Within the promoters and enhancers of NF-κB-responsive genes, we identified clusters of non-consensus κB DNA sites, many exhibiting low affinity for ...
Shandy Shahabi, Tapan Biswas, Yuting Shen, Rose Sanahmadi, Yaya Zou, Gourisankar Ghosh   +5 more
openaire   +3 more sources

Coronavirus M Protein Hijacks Toll‐Interacting Protein (TOLLIP) to Suppress NF‐κB Signaling and Promote Immune Evasion

MedComm, Volume 7, Issue 7, July 2026.
Under physiological conditions, pathogenic stimuli activate TLR/IL1‐R signaling, triggering TOLLIP dissociation from IRAK1 and subsequent IRAK1 phosphorylation, TRAF6 ubiquitination, and NF‐κB activation. During SARS‐CoV‐2 infection, viral M protein binds TOLLIP and stabilizes the TOLLIP–IRAK1 complex, thereby suppressing NF‐κB signaling, impairing ...
Yabin Zhang, Lu Kang, Yu Zhong, Songjun Shao, Senren Xue, Changliang Liu, Xiaoqi Zheng, Jing‐Wen Lin, Yu Chen, Fengming Luo, Huajing Wan   +10 more
wiley   +1 more source

Transcriptomics Analysis Reveals Dual Axes of Metabolic and Immune Dysregulation in the Progression of NAFLD to HCC

Natural Sciences, Volume 6, Issue 3, July 2026.
The mechanisms driving the progression of NAFLD through NASH, cirrhosis and HCC are unclear. In this study, we have comprehensively analyzed multi‐cohort transcriptomics data of the whole NAFLD spectrum to unlock the paradigm changes in gene expression and its regulation.
Anusha Patodia, Harikeshav Karthik, Sulagna Basu, Varshini Venkatesan, Rakesh Pandey, Gowri Manohari Balachander   +5 more
wiley   +1 more source

NF-κB RelA is a cell-intrinsic metabolic checkpoint restricting glycolysis

Cell & Bioscience
An intrinsic link between metabolism and function in immune cells, and in particular macrophages, has been well established recently. However, the molecular mechanisms controlling the metabolic switch in these sentinel cells for their integral roles in ...
Liwen Li, Lei Han, Zhaoxia Qu
doaj   +1 more source

The stringent response regulates the poly-β-hydroxybutyrate (PHB) synthesis in Azotobacter vinelandii.

PLoS ONE
The stringent response exerted by (p)ppGpp and RNA-polymerase binding protein DksA regulates gene expression in diverse bacterial species. To control gene expression (p)ppGpp, synthesized by enzymes RelA and SpoT, interacts with two sites within the RNA ...
Cristian Camilo Ortiz-Vasco, Soledad Moreno, Luis Alonso Quintero-Navarro, Juliana Berenice Rojo-Rodríguez, Guadalupe Espín   +4 more
doaj   +1 more source

PIAS3 suppresses NF-κB-mediated transcription by interacting with the p65/RelA subunit

, 2019
Nuclear factor-κB (NF-κB) is a transcription factor critical for key cellular processes, including immune response, apoptosis, and cell cycle progression.
김재상, 이수영
core   +1 more source