Results 121 to 130 of about 36,472 (203)

Targeted Anti‐IL‐1 Immunomodulatory Therapy in Pediatric Onset PPP1R13L‐Related Arrhythmogenic Cardiomyopathy

American Journal of Medical Genetics Part A, Volume 200, Issue 8, Page 1807-1813, August 2026.
ABSTRACT Autosomal recessive loss‐of‐function variants in PPP1R13L cause an ultra‐rare cardiocutaneous syndrome characterized by rapidly progressive arrhythmogenic cardiomyopathy (ACM). PPP1R13L encodes iASPP, which has two potentially overlapping mechanisms driving ACM as both a regulator of NFκB‐mediated inflammation and a binding partner within the ...
Aaron Renberg, Savannah Coppersmith, Owen Merritt, Amer Heider, Adam Helms, Thomas Michniacki, Jack Luxford, Sarah Josephi‐Taylor, Philip Roberts, Joshua Meisner   +9 more
wiley   +1 more source

ETS1–EGR2 facilitates renal cell carcinoma progression by activating NOTCH signalling

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
ETS1 expression is significantly higher in ccRCC samples, and ETS1‐overexpression increases RCC cell malignancies in vitro and tumour growth in nude mice. ETS1 binds to EGR2 and destabilises EGR2 protein, which relieves EGR2's inhibitory effect on NOTCH signalling. NOTCH signalling activation promotes RCC development.
Weifeng Ye, Sishun Gan, Qiang Xu, Xiaoyang Shu, Panpan Dong, Lin Li, Chao Tang   +6 more
wiley   +1 more source

Mechanisms of Lycium barbarum Treatment in Sepsis‐Induced Myocardial Injury: A Network Pharmacology and Experimental Validation Study

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
The chemical characterization of the LB extract confirmed the presence of polysaccharides and specific small‐molecule constituents (e.g., rutin, isoquercitrin). Network pharmacology analysis predicted that the bioactive components of LB were able to interact with core targets such as TP53, AKT1, and JUN, and molecular docking simulations suggested ...
Ruxin Liu, Chunxia Ma, Yujiao Tang, Xue Bai, Liting Yang, Yi Hu, Zesu Niu, Weiliang Xue, Ling Zhang, Mengfei Chen   +9 more
wiley   +1 more source

Industrial Hydrocarbons Exposure Deteriorates Sperm Integrity and Reproductive Function

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
ABSTRACT Occupational exposure to polycyclic aromatic hydrocarbons (PAHs) or metal fumes in the workplace may be detrimental to male fertility. The present study compared sperm concentration, total motility, strict morphology and oxidative stress and SDF levels between 81 men, controls (n = 17) and workers from plastic industry workers (n = 18), steel ...
Madhan Kumar Pichandi, Babujanarthanam Ranganathanan, Doraiah Abilash   +2 more
wiley   +1 more source

Unlocking the Bioactive Potential of Streptomyces: A Multidisciplinary Approach to Strain Improvement

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
This paper aims to address critical gaps in the literature by providing a comprehensive, integrative synthesis of recent advances in Streptomyces strain improvement, with a particular focus on optimizing secondary metabolite production through a multidisciplinary approach.
Anum Goraya, Anila Fariq, Aneela Fatima, Syed Hussain Imam Abidi, Sohail Ameer Marwat, Gholamreza Abdi   +5 more
wiley   +1 more source

Metabolic Regulation of Macrophages in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Extracellular metabolites drive metabolic rewiring of glucose, lipid, and amino acid pathways in macrophages, steering their polarization toward pro‐ or anti‐inflammatory phenotypes and shaping a wide range of disease processes. Macrophages from different tissues display distinct metabolic signatures, and therapeutic strategies that target these ...
Shan Huang, Yu Zhang, Jiali Min, Jiahui Yang, Yuchen Li, Hao Zhang, Shanshan Liu   +6 more
wiley   +1 more source

Triphala Targets the SLC7A11–GSH–GPX4 Axis to Trigger Ferroptosis in Oral Cancer: An Integrated Network Pharmacology, Molecular Docking, and Experimental Validation Study

Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.
Triphala targets ferroptosis‐related pathways in oral cancer through multi‐compound, multi‐target interactions identified by network pharmacology and molecular docking. In CAL‐27 cells, Triphala suppresses the GPX4/SLC7A11 axis, promotes iron accumulation and lipid peroxidation, and supports an eight‐gene prognostic signature.
Yiwei Zhao, Simin Li, Linxin Jiang, Deborah Kreher, Gerhard Schmalz, Andreas Fichter, Xianda Hu   +6 more
wiley   +1 more source

Gut‐Derived Sodium Butyrate Attenuates Liver Fibrosis by Inhibiting Aerobic Glycolysis via the HDAC3/c‐Myc Signaling Axis

The FASEB Journal, Volume 40, Issue 14, 31 July 2026.
This study explores the molecular mechanisms by which NaB ameliorates liver fibrosis from the perspectives of the gut–liver axis and metabolic reprogramming. In vivo and in vitro experiments demonstrate that gut‐derived NaB may alleviate liver injury and fibrosis by inhibiting hepatic stellate cell activation and aerobic glycolysis through the HDAC3/c ...
Yong Sun, Huayue Wu, Yutong Zhou, Pengsheng Yin, Long Wu, Haiyang Li, Shi Zuo, Zhe Yang, Kun Cao   +8 more
wiley   +1 more source

Tuberous sclerosis complex 2 association with RelA/p65 is critical for NF-κB activation and endothelial cell inflammation. [PDF]

Cell Commun Signal
Tahir I, Najar RA, Rahman A.
europepmc   +1 more source

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source