Results 101 to 110 of about 36,830 (233)

Effects of Common Food Additives Kappa‐, Iota‐ and Lambda‐Carrageenans on Intestinal Epithelial Cell Activation and Barrier Disruption

Clinical &Experimental Allergy, EarlyView.
Carrageenans, widely used food additives, disrupted intestinal epithelial integrity in a gut‐on‐a‐chip model. All types (κ‐, ɩ‐, λ‐) induced cytotoxicity, inflammation and tight junction (TJ) disruption, triggering TNF‐mediated immune responses. λ‐Carrageenan had the most severe effects, supporting the Epithelial Barrier Theory linking food additives ...
Na Sun, Yagiz Pat, Huseyn Babayev, Sena Ardicli, Ismail Ogulur, Xianting Bu, Manru Li, Shuqi Jia, Beate Rückert, Raja Dhir, Kari C. Nadeau, Mubeccel Akdis, Cezmi A. Akdis, Duygu Yazici   +13 more
wiley   +1 more source

Aging-related signature stratifies LUAD prognosis and uncovers senescence-induced chemoresistance via NF-κB/RELA activation

Respiratory Research
Background Lung adenocarcinoma (LUAD) is the most common subtype of lung cancer and a leading cause of cancer-related mortality worldwide. Aging has emerged as a significant risk factor for LUAD, with evidence suggesting that age-associated biological ...
Chengyue Zhu, Ying Dong, Yue Dong, Xinyu Shang, Jintong Dong, Tingting Ge, Zhijun Jie, Jia Li, Yi Zang, Jindong Shi   +9 more
doaj   +1 more source

Selective Antagonists of the Bronchiolar Epithelial NF-κB-Bromodomain-Containing Protein 4 Pathway in Viral-Induced Airway Inflammation

Cell Reports, 2018
Summary: The mechanisms by which the mammalian airway detects invading viral pathogens to trigger protective innate neutrophilic inflammation are incompletely understood.
Bing Tian, Zhiqing Liu, Jun Yang, Hong Sun, Yingxin Zhao, Maki Wakamiya, Haiying Chen, Erik Rytting, Jia Zhou, Allan R. Brasier   +9 more
doaj   +1 more source

Lactate‐Primed NETosis Modulates Hepatic Regeneration During Acute Liver Failure via the TLR9/KLF15/AJUBA Axis

Cell Proliferation, EarlyView.
This study elucidates a novel Kupffer cell‐neutrophil‐hepatocyte axis that drives metabolic‐immune crosstalk during acute liver failure. Specifically, lactate‐primed NETs release links metabolic reprogramming to NETosis‐induced regenerative failure in hepatocytes via the TLR9/KLF15/AJUBA axis.
Jin Guo, Xiaoya Zhang, Danmei Zhang, Chunxia Shi, Luwen Wang, Zuojiong Gong   +5 more
wiley   +1 more source

NF-κB RelA regulates temporal oligodendrocyte differentiation in the postnatal brains

Frontiers in Cellular Neuroscience
The NF-κB signaling pathway responds to a diverse range of cytokines and extracellular stresses, regulating immune responses, inflammation, cell proliferation, and cell death.
Kamonrapat Sompub, Norihisa Bizen, Albert S. Baldwin, Albert S. Baldwin, Hirohide Takebayashi, Hirohide Takebayashi, Hirohide Takebayashi   +6 more
doaj   +1 more source

Earliest innate immune responses require macrophage RelA during pneumococcal pneumonia.

, 2011
NF-?B regulates cytokine expression to initiate and control the innate immune response to lung infections. The NF-?B protein RelA is critical for pulmonary host defense during Streptococcus pneumoniae pneumonia, but the cell-specific roles of this ...
Pittet, LA;Quinton, LJ;Yamamoto, K;Robson, BE;Ferrari, JD;Algul, H;Schmid, RM;Mizgerd, JP
core   +1 more source

Women in business: Gender and commercial space in nineteenth‐century Glasgow

The Economic History Review, EarlyView.
Abstract Focusing on women entrepreneurs in a large British city, we examine how women's commercially listed businesses populated that city. Using commercial property rental records, our study allows us to understand sectoral variation and the distribution of businesses across the city and to assess both the absolute and relative contribution of women ...
Graeme Acheson, Gill Newton, Linda Perriton   +2 more
wiley   +1 more source

IκB Kinase α and p65/RelA Contribute to Optimal Epidermal Growth Factor-induced c- fos Gene Expression Independent of IκBα Degradation

, 2004
Mitogenic activation of expression of immediate-early genes, such as c-fos, is controlled through signal-induced phosphorylation of constitutively bound transcription factors that is correlated with a nucleosomal response that involves inducible ...
Anest, Vasiliki, Baldwin Jr., Albert S., Cogswell, Patricia C.   +2 more
core   +1 more source

Adipocyte‐specific NIK depletion enhances energy metabolism and glucose tolerance in mice

The FEBS Journal, EarlyView.
Obesity is associated with reduced energy expenditure and increased hepatic lipid accumulation. This study reveals that loss of NIK in adipocytes stimulates FGF21‐driven expression of thermogenic genes, including UCP1, and mitochondrial uncoupled respiration.
Atakan Ozcan, Caroline Uslucan, Aleyna Kizilyer, Samet Agca, Aylin Karatas, Sanaz Naghizadeh, Bahar Zehra Camurdanoglu Weber, Sukru Anil Dogan, Serkan Kir   +8 more
wiley   +1 more source

Tetra-O-methyl nordihydroguaiaretic acid (Terameprocol) inhibits the NF-κB-dependent transcription of TNF-α and MCP-1/CCL2 genes by preventing RelA from binding its cognate sites on DNA

Journal of Inflammation, 2010
Background Tetra-O-methyl nordihydroguaiaretic acid, also known as terameprocol (TMP), is a naturally occurring phenolic compound found in the resin of the creosote bush.
Scholle Frank, Wilson Jason R, Sikes Michael L, Oyegunwa Akinbolade O, Laster Scott M   +4 more
doaj   +1 more source