Results 91 to 100 of about 36,830 (233)

Transcriptional activation of the interleukin-8 gene by respiratory syncytial virus infection in alveolar epithelial cells: nuclear translocation of the RelA transcription factor as a mechanism producing airway mucosal inflammation [PDF]

Journal of Virology, 1996
The most common cause of epidemic pediatric respiratory disease, respiratory syncytial virus (RSV), stimulates interleukin-8 (IL-8) synthesis upon infecting airway epithelium, an event necessary for the development of mucosal inflammation. We investigated the mechanism for enhanced IL-8 production in human A549 type II pulmonary epithelial cells ...
R, Garofalo, M, Sabry, M, Jamaluddin, R K, Yu, A, Casola, P L, Ogra, A R, Brasier   +6 more
openaire   +2 more sources

AOSNP‐ADAPTR resource level‐based recommendations on practical diagnostic strategies for ependymomas

Brain Pathology, EarlyView.
Adapting Diagnostic Approaches for Practical Taxonomy in Resource‐Restrained Regions (ADAPTR) recommendations for ependymomas in resource‐restrained settings (RL = resource level; created in BioRender). Abstract Ependymomas are uncommon primary tumors of the central nervous system (CNS) that affect both children and adults.
Laveniya Satgunaseelan, Michael E. Buckland, Geeta Chacko, Kenta Masui, Junji Shibahara, Vani Santosh, Maysa Al‐Hussaini, Sung‐Hye Park, Tarik Tihan, Ho‐Keung Ng, Pieter Wesseling, David N. Louis, Chitra Sarkar, Takashi Komori   +13 more
wiley   +1 more source

MAP17 Enhances Chemoresistance and Tumorigenicity of Glioblastoma‐Initiating Cells via the Canonical NF‐кB Pathway

Cancer Science, EarlyView.
MAP 17 is identified as highly expressed in TMZ‐resistant glioblastoma‐initiating cells (GICs). MAP17 enhances GIC proliferation, TMZ resistance, and tumorigenicity through NF‐κB/RELA‐dependent BCL2 upregulation. ABSTRACT Glioblastoma (GBM) is the most common malignant brain tumor in adults.
Shenshen Dou, You Lee Son, Toru Kondo
wiley   +1 more source

A Nationwide Central Diagnosis for Pediatric CNS Tumors in Japan: The JCCG Brain Tumor and Pathology Committees

Cancer Science, EarlyView.
In this report, we present the results of a nationwide initiative launched by the Japan Children's Cancer Group to provide integrated diagnoses for pediatric central nervous system (CNS) tumors, incorporating central pathological review and molecular profiling.
Yoshiko Nakano, Junko Hirato, Takako Yoshioka, Tetsuya Takimoto, Sumihito Nobusawa, Kaishi Satomi, Ran Tomomasa, Seiji Yamada, Taku Homma, Shoh Sasaki, Ayako Yamazaki, Maki Sakaguchi, Yasuhide Takeuchi, Nei Fukazawa, Kai Yamasaki, Kohei Fukuoka, Yui Shinohara Kimura, Yuki Nagayama, Yohei Inoue, Akira Miyahira, Ema Yoshioka, Asako Katsuma, Hayato Fukusumi, Tomoko Shofuda, Yuko Hibiya, Yuko Matsushita, Mai Honda Kitahara, Yuki Yomoda, Miho Kato, Michael D. Taylor, Yasuhito Arai, Tatsuhiro Shibata, Hiroaki Sakamoto, Keita Terashima, Yoshiki Arakawa, Toshihiro Kumabe, Ryo Nishikawa, Junichi Hara, Yonehiro Kanemura, Koichi Ichimura   +39 more
wiley   +1 more source

Table_2_The NF-κB RelA transcription factor is not required for CD8+ T-cell function in acute viral infection and cancer.xlsx

CD8+ T cells are critical mediators of pathogen clearance and anti-tumor immunity. Although signaling pathways leading to the activation of NF-κB transcription factors have crucial functions in the regulation of immune responses, the CD8+ T cell ...
Laurie Tonon (15162537), Guilhem Lalle (18102199), Pierre Stéphan (7319153), Insaf Boutemine (18102196), Philippe A. Cassier (14982849), Ulf Klein (6547655), Mélanie Wencker (207512), Julie Twardowski (18102193), Khaled Bouherrou (18102202), Véronique Baud (318941), Anthony Ferrari (161538), Maud Plaschka (18102187), Marlène Perrin-Niquet (18102190), Baptiste Eluard (3635830), Roxane Pommier (18102205), Allison Voisin (9740175), Yenkel Grinberg-Bleyer (7003466)   +16 more
core   +1 more source

Spatial Transcriptomics and Bulk RNA‐Seq Analysis Revealed Molecular Classification of Invasive Lobular Carcinoma

Cancer Science, EarlyView.
Spatial transcriptomics and bulk RNA‐seq data analysis revealed the molecular characteristics of invasive lobular carcinoma (ILC). ILC was classified into three clusters: proliferative, immunoreactive, and stromal‐rich, with different prognoses. ABSTRACT Invasive lobular carcinoma (ILC) is a special type of breast cancer.
Momoko Tokura, Jun Nakayama, Hironori Suzuki, Mieko Ochi, Miyaka Umemori, Sho Shiino, Masayuki Yoshida, Shin Takayama, Yasushi Yatabe, Yusuke Yamamoto   +9 more
wiley   +1 more source

Table_1_The NF-κB RelA transcription factor is not required for CD8+ T-cell function in acute viral infection and cancer.xlsx

CD8+ T cells are critical mediators of pathogen clearance and anti-tumor immunity. Although signaling pathways leading to the activation of NF-κB transcription factors have crucial functions in the regulation of immune responses, the CD8+ T cell ...
Laurie Tonon (15162537), Guilhem Lalle (18102199), Pierre Stéphan (7319153), Insaf Boutemine (18102196), Philippe A. Cassier (14982849), Ulf Klein (6547655), Mélanie Wencker (207512), Julie Twardowski (18102193), Khaled Bouherrou (18102202), Véronique Baud (318941), Anthony Ferrari (161538), Maud Plaschka (18102187), Marlène Perrin-Niquet (18102190), Baptiste Eluard (3635830), Roxane Pommier (18102205), Allison Voisin (9740175), Yenkel Grinberg-Bleyer (7003466)   +16 more
core   +1 more source

Novel determinants of antibiotic resistance : identification of mutated loci in highly methicillin-resistant subpopulations of methicillin-resistant Staphylococcus aureus

, 2014
This work was supported by a grant from the U.S. Public Health Service 2 RO1 AI457838-14 and by grant UL1 TR000043-07S1 from the National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH) Clinical and Translational ...
Kim, Choonkeun, Hermínia de Lencastre, Matthew T. J. Holden, Holden, Matthew T J, María Pardos de la Gándara, Tomasz, Alexander, Parkhill, Julian, de Lencastre, Hermínia, Alexander Tomasz, Stephen D. Bentley, Janina Dordel, Dordel, Janina, Pardos de la Gándara, María, Chung, Marilyn, Bentley, Stephen D, Marilyn Chung, Choonkeun Kim, Julian Parkhill   +17 more
core   +1 more source

Organ‐Specific Cancer‐Associated Fibroblast Subtypes Across the Digestive System Linked to Cancer Hallmarks

Cancer Science, EarlyView.
We integrated 14 single‐cell RNA‐seq datasets and 18 bulk cohorts to define eight CAF subtypes in GI cancers. myCAF1 and myCAF2 promoted immunosuppressive, poor‐prognosis niches, whereas iCAF1 was linked to favorable prognosis and antitumor immunity.
Huaitao Wang, Takashi Semba, Atsuko Yonemura, Hiroshi Naito, Lingfeng Fu, Takuya Tajiri, Masaaki Iwatsuki, Takatsugu Ishimoto   +7 more
wiley   +1 more source

Activation of the transcription factor, nuclear factor kappa-B, during the estrous cycle and early pregnancy in the pig

Reproductive Biology and Endocrinology, 2010
Establishment and maintenance of pregnancy in the pig involves intricate communication between the developing conceptuses and the maternal endometrium. This process occurs during trophoblast elongation which is spaciotemporally associated with conceptus ...
Hayashi Kanako, Ritchey Jerry W, Reagan Patrick, Mathew Daniel, Ashworth Morgan D, Ross Jason W, Spencer Thomas E, Lucy Matthew, Geisert Rodney D   +8 more
doaj   +1 more source