Results 181 to 190 of about 35,051 (207)
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Russian Journal of Genetics: Applied Research, 2017
The aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor, is involved in a wide range of critical cellular events in response to endogenous signals or xenobiotics. 2,3,7,8-Tetrachlorodibenzo-para-dioxin (TCDD) is one of the AhR ligands with the maximum affinity for AhR. TCDD is the most toxic among the dioxin xenobiotics and induces
E. V. Kashina +5 more
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The aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor, is involved in a wide range of critical cellular events in response to endogenous signals or xenobiotics. 2,3,7,8-Tetrachlorodibenzo-para-dioxin (TCDD) is one of the AhR ligands with the maximum affinity for AhR. TCDD is the most toxic among the dioxin xenobiotics and induces
E. V. Kashina +5 more
openaire +1 more source
p53-mediated repression of nuclear factor-kappaB RelA via the transcriptional integrator p300.
Cancer research, 1998The p53 tumor suppressor gene plays an instrumental role in transcriptional regulation of target genes involved in cellular stress responses. p53-dependent transactivation and transrepression require its interaction with p300/CBP, a coactivator that also interacts with the RelA subunit of nuclear factor-kappaB.
Ravi R. +7 more
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Clinical cancer research : an official journal of the American Association for Cancer Research, 2002
Activation of transcription factor nuclear factor-kappaB (NF-kappaB) has been shown to play a role in cell proliferation, apoptosis, cytokine production, and oncogenesis. The purpose of this study was to determine whether NF-kappaB is constitutively activated in human gastric carcinoma tissues and, if so, to determine any correlation between NF-kappaB ...
N, Sasaki +10 more
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Activation of transcription factor nuclear factor-kappaB (NF-kappaB) has been shown to play a role in cell proliferation, apoptosis, cytokine production, and oncogenesis. The purpose of this study was to determine whether NF-kappaB is constitutively activated in human gastric carcinoma tissues and, if so, to determine any correlation between NF-kappaB ...
N, Sasaki +10 more
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Clinical cancer research : an official journal of the American Association for Cancer Research, 1999
Pancreatic adenocarcinoma is a leading cause of adult cancer mortality in the United States. Recent studies have revealed that point mutation of the K-ras oncogene is a common event in pancreatic cancer, and oncogenesis mediated by Ras may also involve activation of Rel/nuclear factor (NF)-kappa B transcription factors. Furthermore, the c-rel member of
W, Wang +5 more
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Pancreatic adenocarcinoma is a leading cause of adult cancer mortality in the United States. Recent studies have revealed that point mutation of the K-ras oncogene is a common event in pancreatic cancer, and oncogenesis mediated by Ras may also involve activation of Rel/nuclear factor (NF)-kappa B transcription factors. Furthermore, the c-rel member of
W, Wang +5 more
openaire +1 more source
Pediatric Research, 1996
In previous studies, we have shown that RSV replication in A549 cells (a type II alveolar epithelial cell line) induces a dose- and time-dependent release of IL-8. We have subsequently investigated the mechanisms of IL-8 induction. By RT-PCR, the IL-8 mRNA, barely detectable in control cells, was strongly induced by RSV infection; the IL-8 mRNA ...
Roberto Garofalo +7 more
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In previous studies, we have shown that RSV replication in A549 cells (a type II alveolar epithelial cell line) induces a dose- and time-dependent release of IL-8. We have subsequently investigated the mechanisms of IL-8 induction. By RT-PCR, the IL-8 mRNA, barely detectable in control cells, was strongly induced by RSV infection; the IL-8 mRNA ...
Roberto Garofalo +7 more
openaire +1 more source
Tsitologiia, 1999
DNA binding activity and intracellular distribution of transcription factor NF-kappa B in primary embryo fibroblast (REF) cells transformed by the complementing oncogenes E1A plus cHa-ras have been studied. By means of a gel retardation assay with a regulatory element kappa B, we showed that DNA binding activity of NF-kappa B increased upon ...
Z A, Darieva +2 more
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DNA binding activity and intracellular distribution of transcription factor NF-kappa B in primary embryo fibroblast (REF) cells transformed by the complementing oncogenes E1A plus cHa-ras have been studied. By means of a gel retardation assay with a regulatory element kappa B, we showed that DNA binding activity of NF-kappa B increased upon ...
Z A, Darieva +2 more
openaire +2 more sources
RelA/NF-κB transcription factor associates with α-actinin-4
Experimental Cell Research, 2008Vladimir N. Babakov +8 more
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Multimodal interactions of drugs, natural compounds and pollutants with the gut microbiota
Nature Reviews Microbiology, 2022Anna Elisabeth Lindell +2 more
exaly
AbstractThe protein interactome of p65 / RELA, the most active subunit of the transcription factor (TF) NF-κB, has not been previously determined in living cells. Using p65-miniTurbo fusion proteins, we identified by biotin tagging > 350 RELA interactors from untreated and IL-1α-stimulated cells, including many TFs (47 % of all interactors) and >
Lisa Leib +12 more
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Lisa Leib +12 more
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Supratentorial ependymoma in childhood: more than just RELA or YAP
Acta Neuropathologica, 2021Stephanie Theresa Jünger +2 more
exaly