Results 181 to 190 of about 36,472 (203)

Transcription factor RELA promotes hepatocellular carcinoma progression by promoting the transcription of m6A modulator METTL3

Pathology Research and Practice
To explore the biological function of RELA proto-oncogene, NF-kB subunit (RELA) in hepatocellular carcinoma (HCC) progression, and its potential regulatory effects on the regulators of m6A modification.GEPIA, UALCAN and Human Protein Atlas databases were applied to analyze the expression characteristics of RELA in HCC tissues and non-cancer liver ...
Yongbin Zheng, Wenhong Deng
exaly   +3 more sources

Inferring Genome-Wide Functional Modulatory Network: A Case Study on NF-κB/RelA Transcription Factor [PDF]

Journal of Computational Biology, 2015
How different pathways lead to the activation of a specific transcription factor (TF) with specific effects is not fully understood. We model context-specific transcriptional regulation as a modulatory network: triplets composed of a TF, target gene, and modulator. Modulators usually affect the activity of a specific TF at the posttranscriptional level
Xueling Li, Andrzej Kudlicki, Allan R Brasier   +2 more
exaly   +3 more sources

Immortalized embryonic mouse fibroblasts lacking the RelA subunit of transcription factor NF-κB have a malignantly transformed phenotype [PDF]

Oncogene, 2002
The RelA transcription factor is part of dimeric complexes, most commonly either p50-RelA (NF-kappaB) heterodimers or RelA homodimers, that control a variety of cellular processes. Immortalized embryonic fibroblasts established from rela knockout mice have previously been shown to be more sensitive to apoptosis induced by tumor necrosis factor (TNF ...
Thomas D Gilmore, Gilmore Thomas D
exaly   +7 more sources

Optogenetic control of RelA reveals effect of transcription factor dynamics on downstream gene expression

2022
Abstract Many transcription factors (TFs) translocate to the nucleus with varied dynamic patterns in response to different inputs. A notable example of such behavior is RelA, a subunit of NF-κB, which translocates to the nucleus with either pulsed or sustained dynamics, depending on the stimulus.
Lindsey C. Osimiri, Alain R. Bonny, Seesha R. Takagishi, Stefanie Luecke, Nina Riehs, Alexander Hoffmann, Hana El-Samad   +6 more
openaire   +1 more source

Expression of constitutively active Nuclear-κB RelA transcription factor in blasts of acute myeloid leukemia

Human Pathology, 2004
The nuclear transcription factor NF-kappa B regulates cell survival, proliferation, and differentiation. Little is known about NF-kappa B in myeloid malignancies. In this report, we assessed NF-kappa B in a group of myeloid neoplasms by using an electrophoretic mobility shift assay (EMSA) and immunofluorescence methods in freshly isolated leukemia ...
Carlos E, Bueso-Ramos, Frederico C, Rocha, Shishir, Shishodia, L Jeffrey, Medeiros, Hagop M, Kantarjian, Saroj, Vadhan-Raj, Zeev, Estrov, Terry L, Smith, Martin H, Nguyen, Bharat B, Aggarwal   +9 more
openaire   +2 more sources

RelA and RelB Transcription Factors in Distinct Thymocyte Populations Control Lymphotoxin-Dependent Interleukin-17 Production in γδ T Cells [PDF]

Immunity, 2011
The NF-κB transcription factor regulates numerous immune responses but its contribution to interleukin-17 (IL-17) production by T cells is largely unknown. Here, we report that IL-17, but not interferon-γ (IFN-γ), production by γδ T cells required the NF-κB family members RelA and RelB as well as the lymphotoxin-β-receptor (LTβR).
Thomas Hehlgans, Falk Weih
exaly   +3 more sources

Expression dynamics of the REL, RELA, and IRF1 transcription factors in U937 macrophages after dioxin exposure

Russian Journal of Genetics: Applied Research, 2017
The aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor, is involved in a wide range of critical cellular events in response to endogenous signals or xenobiotics. 2,3,7,8-Tetrachlorodibenzo-para-dioxin (TCDD) is one of the AhR ligands with the maximum affinity for AhR. TCDD is the most toxic among the dioxin xenobiotics and induces
Mordvinov V A
exaly   +2 more sources

The DEAD‐box RNA helicase DDX1 interacts with RelA and enhances nuclear factor kappaB‐mediated transcription

Journal of Cellular Biochemistry, 2008
AbstractDEAD‐box RNA helicases constitute the largest family of RNA helicases and are involved in many aspects of RNA metabolism. In this study, we identified RelA (p65), a subunit of nuclear factor‐kappaB (NF‐κB), as a cellular co‐factor of DEAD‐box RNA helicase DDX1, through mammalian two hybrid system and co‐immunoprecipitation assay.
Musarat, Ishaq, Li, Ma, Xiaoyun, Wu, Yongxin, Mu, Ji'an, Pan, Jiajie, Hu, Tao, Hu, Qiong, Fu, Deyin, Guo   +8 more
openaire   +2 more sources

RelA/NF-kappaB transcription factor associates with alpha-actinin-4.

Experimental cell research, 2008
The NF-kappaB/RelA family of transcription factors regulates inducible transcription of a large number of genes in response to diverse stimuli. Little is known, however, about the location of NF-kappaB in the cytoplasm and the transport mechanism to the nucleus. We found that NF-kappaB is associated with the actin-binding protein alpha-actinin-4.
Vladimir N, Babakov, Olga A, Petukhova, Lidia V, Turoverova, Irina V, Kropacheva, Dmitri G, Tentler, Anastasia V, Bolshakova, Ekaterina P, Podolskaya, Karl-Eric, Magnusson, George P, Pinaev   +8 more
openaire   +1 more source

p53-mediated repression of nuclear factor-kappaB RelA via the transcriptional integrator p300.

Cancer research, 1998
The p53 tumor suppressor gene plays an instrumental role in transcriptional regulation of target genes involved in cellular stress responses. p53-dependent transactivation and transrepression require its interaction with p300/CBP, a coactivator that also interacts with the RelA subunit of nuclear factor-kappaB.
Ravi R., Mookerjee B., van Hensbergen Y., Bedi G. C., Giordano A., El-Deiry W. S., Fuchs E. J., Bedi A.   +7 more
openaire   +2 more sources