Results 111 to 120 of about 2,323,002 (379)

Unconventional mRNA processing and degradation pathways for the polycistronic yrzI (spyTA) mRNA in Bacillus subtilis

FEBS Letters, EarlyView.
The S1025 peptide is the major antidote to the YrzI toxin, which we renamed here as SpyT (Small Peptide YrzI Toxin) and SpyA (Small Peptide YrzI Antitoxin) (1). Degradation of the toxin–antitoxin spyTA mRNA, either by a translation‐dependent cleavage by the endoribonuclease Rae1 (2) or by direct attack by 3′‐exoribonucleases (3), also contributes to ...
Laetitia Gilet, Magali Leroy, Alexandre Maes, Ciarán Condon, Frédérique Braun   +4 more
wiley   +1 more source

Transcription factor DREF regulates expression of the microRNA gene bantam in Drosophila melanogaster

Вавиловский журнал генетики и селекции
The bantam gene encodes a vital microRNA and has a complex expression pattern in various tissues at different stages of Drosophila development. This microRNA is involved in the control of normal development of the ocu lar and wing imaginal discs, the ...
M. B.  Schwartz, M. M. Prudnikova, O. V. Andreenkov, E. I. Volkova, I. F. Zhimulev, O. V. Antonenko, S.  A. Demakov   +6 more
doaj   +1 more source

The SOX11 transcription factor is a critical regulator of basal-like breast cancer growth, invasion, and basal-like gene expression. [PDF]

, 2016
Basal-like breast cancers (BLBCs) are aggressive breast cancers associated with poor survival. Defining the key drivers of BLBC growth will allow identification of molecules for targeted therapy.
Brown, Powel H, Hilsenbeck, Susan G, Mazumdar, Abhijit, Savage, Michelle, Shepherd, Jonathan H, Tsimelzon, Anna, Uray, Ivan P   +6 more
core   +1 more source

Conserved noncoding sequences highlight shared components of regulatory networks in dicotyledonous plants [PDF]

, 2012
Conserved noncoding sequences (CNSs) in DNA are reliable pointers to regulatory elements controlling gene expression. Using a comparative genomics approach with four dicotyledonous plant species (Arabidopsis thaliana, papaya [Carica papaya], poplar ...
Barrington, Christopher, Baxter, Laura, Beynon, Jim, Buchanan-Wollaston, Vicky, Denby, Katherine J., Dyer, Nigel, Hickman, R. D. G., Jironkin, Aleksey, Krusche, Peter, Moore, Jonathan D., Ott, Sascha, Tiskin, Alexander   +11 more
core   +2 more sources

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

Molecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever, Renske D. M. Steenbergen   +1 more
wiley   +1 more source

Metabolic gatekeeper function of B-lymphoid transcription factors. [PDF]

, 2017
B-lymphoid transcription factors, such as PAX5 and IKZF1, are critical for early B-cell development, yet lesions of the genes encoding these transcription factors occur in over 80% of cases of pre-B-cell acute lymphoblastic leukaemia (ALL).
Borkhardt, Arndt, Braas, Daniel, Cazzaniga, Giovanni, Cazzaniga, Valeria, Chan, Lai N, Chen, Zhengshan, Cosgun, Kadriye Nehir, Dickins, Ross A, Ernst, Thomas, Geng, Huimin, Graeber, Thomas G, Hochhaus, Andreas, Hurtz, Christian, Koeffler, H Phillip, Konopleva, Marina, Kornblau, Steven M, Lee, Jae-Woong, Liu, Grace J, Milne, Thomas A, Müschen, Markus, Pufall, Miles A, Ross, Theodora S, Schjerven, Hilde, Shojaee, Seyedmehdi, Sánchez-García, Isidro, Xiao, Gang, Yamamoto, Keith R   +26 more
core  

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

Negative Example Aided Transcription Factor Binding Site Search [PDF]

arXiv, 2011
Computational approaches to transcription factor binding site identification have been actively researched for the past decade. Negative examples have long been utilized in de novo motif discovery and have been shown useful in transcription factor binding site search as well.
arxiv  

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

Molecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker, Samantha Hasenleithner, Rupert Bartsch, Simon P. Gampenrieder, Daniel Egle, Christian F. Singer, Gabriel Rinnerthaler, Michael Hubalek, Katja Schmitz, Zsuzsanna Bago‐Horvath, Andreas Petzer, Sonja Heibl, Ellen Heitzer, Marija Balic, Michael Gnant   +14 more
wiley   +1 more source

Engineering orthogonal dual transcription factors for multi-input synthetic promoters [PDF]

, 2016
Synthetic biology has seen an explosive growth in the capability of engineering artificial gene circuits from transcription factors (TFs), particularly in bacteria. However, most artificial networks still employ the same core set of TFs (for example LacI,
Broedel, AK, Isalan, M, Jaramillo, A
core   +2 more sources