Results 111 to 120 of about 15,143,293 (401)

An RxLR effector from phytophthora infestans prevents re-localisation of two plant NAC transcription factors from the endoplasmic reticulum to the nucleus [PDF]

, 2013
The plant immune system is activated following the perception of exposed, essential and invariant microbial molecules that are recognised as non-self. A major component of plant immunity is the transcriptional induction of genes involved in a wide array ...
A Block, A Bombarely, A Stamatakis, AN Olsen, AO Avrova, AP Rehmany, BJ Haas, BM Tyler, Brett Tyler, C Lacomme, C Zipfel, D Chinchilla, D Darriba, D Dou, DGO Saunders, EA van der Biezen, EM Gilroy, EM Gilroy, G Fabro, H-K Yoon, Hazel McLellan, HM Nguyen, HP Nguyen, I Hein, JD Jones, JIB Bos, Jim L. Beynon, JL Dangl, Juan Morales, K Bouwmeester, L Baxter, L Deslandes, Leighton Pritchard, M Karimi, M-C Caillaud, MD Curtis, Miles R. Armstrong, MS Mukhtar, N Ishihama, NK Clay, P Chomczynski, Paul R. J. Birch, Petra C. Boevink, PJ Seo, PJ Seo, PRJ Birch, PRJ Birch, Q Wang, S Capella-Gutierrez, S Dong, S Lee, S Moller, S Puranik, S Rivas, S-G Kim, S-Y Kim, SC Whisson, SK Oh, Sonia Gomez, SR Eddy, Stephen C. Whisson, T Boller, T Hoppe, T Ren, T Ren, TO Bozkurt, V Senchou, Y Liu, Y-J Lu, Y-S Kim, Z Nimchuk   +70 more
core   +4 more sources

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Pioneer transcription factors shape the epigenetic landscape

Journal of Biological Chemistry, 2018
Pioneer transcription factors have the unique and important role of unmasking chromatin domains during development to allow the implementation of new cellular programs.
Alexandre Mayran, J. Drouin
semanticscholar   +1 more source

Conserved noncoding sequences highlight shared components of regulatory networks in dicotyledonous plants [PDF]

, 2012
Conserved noncoding sequences (CNSs) in DNA are reliable pointers to regulatory elements controlling gene expression. Using a comparative genomics approach with four dicotyledonous plant species (Arabidopsis thaliana, papaya [Carica papaya], poplar ...
Barrington, Christopher, Baxter, Laura, Beynon, Jim, Buchanan-Wollaston, Vicky, Denby, Katherine J., Dyer, Nigel, Hickman, R. D. G., Jironkin, Aleksey, Krusche, Peter, Moore, Jonathan D., Ott, Sascha, Tiskin, Alexander   +11 more
core   +2 more sources

Intron‐oriented HTLV‐1 integration in an adult T‐cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA

FEBS Letters, EarlyView.
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi, Yuka Hirosawa, Yusaku Sagisaka, Minami Hama, Satoshi Takeda, Jun A. Komano   +5 more
wiley   +1 more source

GATA transcription factors in development and disease

Development, 2018
The GATA family of transcription factors is of crucial importance during embryonic development, playing complex and widespread roles in cell fate decisions and tissue morphogenesis.
Mathieu Tremblay, Oraly Sanchez-Ferras, M. Bouchard   +2 more
semanticscholar   +1 more source

Interleukin 2 transcription factors as molecular targets of cAMP inhibition: delayed inhibition kinetics and combinatorial transcription roles [PDF]

, 1994
Elevation of cAMP can cause gene-specific inhibition of interleukin 2 (IL-2) expression. To investigate the mechanism of this effect, we have combined electrophoretic mobility shift assays and in vivo genomic footprinting to assess both the availability ...
Chen, Dan, Rothenberg, Ellen V.
core   +2 more sources

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

FEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää, Ahmed B. Montaser, Henri Leinonen   +2 more
wiley   +1 more source

Reprogramming of lysosomal gene expression by interleukin-4 and Stat6. [PDF]

, 2013
BACKGROUND: Lysosomes play important roles in multiple aspects of physiology, but the problem of how the transcription of lysosomal genes is coordinated remains incompletely understood.
Bartlett, NW, Brignull, LM, Czimmerer, Z, Daniel, B, Johnston, SL, Meira, LB, Nagy, L, Nohturfft, A, Saidi, H, Villela, I   +9 more
core   +2 more sources

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source