Results 131 to 140 of about 15,365,257 (385)

Targeting GLI Transcription Factors in Cancer

Molecules, 2018
Aberrant activation of hedgehog (Hh) signaling has been observed in a wide variety of tumors and accounts for more than 25% of human cancer deaths. Inhibitors targeting the Hh signal transducer Smoothened (SMO) are widely used and display a good initial ...
Miroslava Didiasova, Liliana Schaefer, Malgorzata Wygrecka   +2 more
doaj   +1 more source

The effect of the termination RHO factor and ribonuclease III on the transcription of bacteriophage φ X174 DNA in vitro [PDF]

, 1976
E.L. Kapitza, E. A. Stukacheva, M.F. Shemyakin   +2 more
openalex   +1 more source

Classes of fast and specific search mechanisms for proteins on DNA

, 2011
Problems of search and recognition appear over different scales in biological systems. In this review we focus on the challenges posed by interactions between proteins, in particular transcription factors, and DNA and possible mechanisms which allow for ...
Abramowitz M, Adam G, Alon U, Benichou O, Braun E, Bresloff J L, Bustamante C, de Haan L, Eliazar I, Elowitz M B, Fersht A, Gasch A P, Grosberg A, Hill A V, Hughes B D, Jeltsch A, M Sheinman, Mirny L, Montroll E W, O Bénichou, Oshanin G, Phillips R, R Voituriez, Redner S, Richey B, Sheinman M, Sheinman M Kafri Y, Terry B J, von Hippel P H, von Hippel P H, von Smoluchowski M, Y Kafri, Zhang M O   +32 more
core   +2 more sources

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

ApiAP2 Transcription Factors in Apicomplexan Parasites

Pathogens, 2019
Apicomplexan parasites are protozoan organisms that are characterised by complex life cycles and they include medically important species, such as the malaria parasite Plasmodium and the causative agents of toxoplasmosis (Toxoplasma gondii) and ...
Myriam D. Jeninga, Jennifer E. Quinn, Michaela Petter   +2 more
doaj   +1 more source

The hardwiring of development: Organization and function of genomic regulatory systems [PDF]

, 1997
The gene regulatory apparatus that directs development is encoded in the DNA, in the form of organized arrays of transcription factor target sites. Genes are regulated by interactions with multiple transcription factors and the target sites for the ...
Arnone, Maria I., Davidson, Eric H.
core  

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

The interaction landscape between transcription factors and the nucleosome

Nature, 2017
Nucleosomes cover most of the genome and are thought to be displaced by transcription factors in regions that direct gene expression. However, the modes of interaction between transcription factors and nucleosomal DNA remain largely unknown.
F. Zhu, L. Farnung, Eevi Kaasinen, Biswajyoti Sahu, Yimeng Yin, Bei Wei, S. Dodonova, K. Nitta, E. Morgunova, Minna Taipale, P. Cramer, J. Taipale   +11 more
semanticscholar   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

NAC transcription factors in plant immunity

Phytopathology Research, 2019
The NAC (NAM, ATAF and CUC) family is one of the largest plant-specific transcription factor (TF) families. Members of this family are implicated in plant growth, development and stress responses.
Xi Yuan, Hui Wang, Jiating Cai, Dayong Li, Fengming Song   +4 more
doaj   +1 more source