Results 131 to 140 of about 2,323,002 (379)

Isolation and characterization of conditional lethal mutants of Escherichia coli defective in transcription termination factor rho. [PDF]

, 1976
Anindya Das, Don Court, Sankar Adhya
openalex   +1 more source

Obesity alters the fitness of peritumoral adipose tissue, exacerbating tumor invasiveness in renal cancer through the induction of ADAM12 and CYP1B1

Molecular Oncology, EarlyView.
Tumor microenvironment drives cancer formation and progression. We analyzed the role of human cancer‐associated adipocytes from patients with renal cell carcinoma (RCC) stratified as lean, overweight, or obese. RNA‐seq demonstrated that, among the most altered genes involved in the tumor–stroma crosstalk, are ADAM12 and CYP1B1, which were proven to be ...
Sepehr Torabinejad, Caterina Miro, Annarita Nappi, Francesco Del Giudice, Annunziata Gaetana Cicatiello, Serena Sagliocchi, Lucia Acampora, Federica Restolfer, Melania Murolo, Emery Di Cicco, Federico Capone, Ciro Imbimbo, Monica Dentice, Felice Crocetto   +13 more
wiley   +1 more source

Editorial: Transcription regulation — Brain development and homeostasis — A finely tuned and orchestrated scenario in physiology and pathology, volume II

Frontiers in Molecular Neuroscience, 2023
Estela M. Muñoz, Verónica Martínez Cerdeño   +1 more
doaj   +1 more source

ApiAP2 Transcription Factors in Apicomplexan Parasites

Pathogens, 2019
Apicomplexan parasites are protozoan organisms that are characterised by complex life cycles and they include medically important species, such as the malaria parasite Plasmodium and the causative agents of toxoplasmosis (Toxoplasma gondii) and ...
Myriam D. Jeninga, Jennifer E. Quinn, Michaela Petter   +2 more
doaj   +1 more source

Noise-filtering features of transcription regulation in the yeast S. cerevisiae [PDF]

arXiv, 2007
Transcription regulation is largely governed by the profile and the dynamics of transcription factors' binding to DNA. Stochastic effects are intrinsic to this dynamics and the binding to functional sites must be controled with a certain specificity for living organisms to be able to elicit specific cellular responses.
arxiv  

The effect of the termination RHO factor and ribonuclease III on the transcription of bacteriophage φ X174 DNA in vitro [PDF]

, 1976
E.L. Kapitza, E. A. Stukacheva, M.F. Shemyakin   +2 more
openalex   +1 more source

Robust acute myeloid leukemia engraftment in humanized scaffolds using injectable biomaterials and intravenous xenotransplantation

Molecular Oncology, EarlyView.
Patient‐derived xenografts (PDXs) can be improved by implantation of a humanized niche. We tested different biomaterials and approaches, and demonstrate that the combination of an injectable biomaterial for scaffold creation plus an intravenous route for acute myeloid leukemia (AML) xenotransplantation provide the most convenient and robust approach to
Daniel Busa, Zdenka Herudkova, Jan Hyl, Jakub Vlazny, Filip Sokol, Kvetoslava Matulova, Adam Folta, Jakub Hynst, Lucy Vojtova, Leos Kren, Martin Repko, Zdenek Racil, Jiri Mayer, Martin Culen   +13 more
wiley   +1 more source

KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells

Molecular Oncology, EarlyView.
We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock, Lina Benzien, Sandra Lange, Maja Huehns, Alexandra Runge, Catrin Roolf, Anett Sekora, Gudrun Knuebel, Hugo Murua Escobar, Christian Junghanss, Anna Richter   +10 more
wiley   +1 more source

NAC transcription factors in plant immunity

Phytopathology Research, 2019
The NAC (NAM, ATAF and CUC) family is one of the largest plant-specific transcription factor (TF) families. Members of this family are implicated in plant growth, development and stress responses.
Xi Yuan, Hui Wang, Jiating Cai, Dayong Li, Fengming Song   +4 more
doaj   +1 more source

Bridging-Induced Phase Separation and Loop Extrusion Drive Noise in Chromatin Transcription [PDF]

arXiv
Transcriptional noise, or heterogeneity, is important in cellular development and in disease. The molecular mechanisms driving it are, however, elusive and ill-understood. Here, we use computer simulations to explore the role of 3D chromatin structure in driving transcriptional noise.
arxiv