Results 151 to 160 of about 15,584,477 (336)
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Regulation of Topoisomerase IIa expression in humans : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Biochemistry at Massey University, Palmerston North, New Zealand [PDF]
, 2006 In mammalian cells, the loss or down-regulation of tumour-suppressor genes and/or the mutation or overexpression of proto-oncogenes, whose products promote unregulated proliferation in cells, characterise the process of malignant transformation.
Senior, Kelly
core
Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes
Cell, 2013 Warren A. Whyte +8 more
semanticscholar +1 more source
How transcription factors drive choice of the T cell fate
Nature reviews. Immunology, 2020 H. Hosokawa, E. Rothenberg
semanticscholar +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Roles of transcription factors, RBPA and SIGF, in the mycobacterium tuberculosis [PDF]
, 2016 The mechanism of prokaryotic transcription has been characterized primarily in the classic system, Escherichia coli, and cannot be confidently extended to include other prokaryotic species, such as those of the Actinobacteria phylum.
Pope, Steven Scott
core +1 more source
Transcription factors in ferroptotic cell death
Cancer Gene Therapy, 2020 Chongshan Dai +5 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Transcriptional regulation of suberin and its response to the environment
Xibei zhiwu xuebao[Objective] Suberin is a polyester type biopolymer that specifically deposits in tissues such as the endodermis, periderm, seed coat, and wound epidermis of plants.
ZHOU Yue, AN Yongping, MA Rong, WANG Pei
doaj +1 more source