Results 71 to 80 of about 9,751,730 (314)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Transcription factors and asthma [PDF]

European Respiratory Journal, 1998
Asthma is characterized by the expression of multiple genes for inflammatory proteins, such as cytokines, enzymes, receptors and adhesion molecules. This is orchestrated by transcription factors, which are proteins that bind to the promoter regions of these genes and may be activated by inflammatory stimuli, such as cytokines.
P J, Barnes, I M, Adcock
openaire   +2 more sources

MYB transcription factors that colour our fruit

, 2008
Anthocyanin concentration is a primary determinant of plant colour. Fruit anthocyanin biosynthesis is controlled by a distinct clade of R2R3 MYB transcription factors.
Hellens, R.P., Allan, A.C., Laing, W.A.
core   +1 more source

Prunus transcription factors: Breeding perspectives

Frontiers in Plant Science, 2015
Many plant processes depend on differential gene expression, which is generally controlled by complex proteins called transcription factors (TFs). In peach, 1,533 TFs have been identified, accounting for about 5.5% of the 27,852 protein-coding genes ...
Valmor João Bianchi, Manuel eRubio, Livio eTrainotti, Ignazio eVerde, Claudio eBonghi, Pedro eMartinez-Gomez   +5 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Transcription factors in megakaryocytes and platelets

Frontiers in Immunology, 2023
Transcription factors bind promoter or regulatory sequences of a gene to regulate its rate of transcription. However, they are also detected in anucleated platelets.
Hengjie Yuan, Hengjie Yuan, Yafan Liu, Jianning Zhang, Jing-fei Dong, Jing-fei Dong, Zilong Zhao, Zilong Zhao   +7 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Nitric oxide sensing in plants is mediated by proteolytic control of group VII ERF transcription factors [PDF]

, 2014
Nitric oxide (NO) is an important signaling compound in prokaryotes and eukaryotes. In plants, NO regulates critical developmental transitions and stress responses.
Coego, Alberto, Gray, Julie E., Pearce, S. P., Theodoulou, F. L., Marin-De La Rosa, N., Pearce, Simon P, Gibbs, Daniel J., Mendiondo, G. M., Lozano-Juste, J., Bachmair, A., Movahedi, Mahsa, Lozano-Juste, Jorge, Hamali, B., Movahedi, M., Sousa Correia, Cristina, Gray, Julie E, Theodoulou, Frederica L, Talloji, P., Gibbs, D. J., Le�n, Jos�, Marín-De La Rosa, Nora Alicia, Pearce, Simon P., Correia, Cristina Sousa, Talloji, Prabhavathi, Tome, D. F. A., Bachmair, Andreas, Alabadí, David, Tomé, Daniel F.A., Holdsworth, Michael J, Alabadi, D., Bassel, George W., Vicente Conde, J. V., Md Isa, Nurulhikma, Tomé, Daniel F A, Tomé, Daniel F. A., Marín-de la Rosa, Nora, Bassel, George, Alabad�, David, Hamali, Bulut, Mar�n-de la Rosa, Nora, Mendiondo, Guillermina M, Vicente Conde, Jorge, Berckhan, S., Beynon, Jim, Berckhan, Sophie, León, José, Tom�, Daniel F.A., Coego, A., Holdsworth, M. J., Isa, N. M., Isa, Nurulhikma M. D., Sousa Correia, C., Mendiondo, Guillermina M., Conde, Jorge Vicente, Coego González, Alberto, Leon, J., Bassel, G. W., Holdsworth, Michael J., Theodoulou, Frederica L., Gibbs, Daniel J; id_orcid, Bassel, George W, Beynon, J., ALABADÍ DIEGO, DAVID, Gray, J. E., Rosa, Nora, Marin-de La, Isa, Nurulhikma Md, Theodoulou, Freddie   +66 more
core   +1 more source

WRKY transcription factors in legumes

BMC Plant Biology, 2018
Background WRKY transcription factors, so named because of the WRKYGQK heptapeptide at the N-terminal end, are widely distributed in plants and play an important role in physiological changes and response to biotic and abiotic stressors.
Hui Song, Weihong Sun, Guofeng Yang, Juan Sun   +3 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source