Results 61 to 70 of about 9,751,730 (314)

Transcription Factors in Cancer

International Journal of Molecular Sciences, 2022
This Special Issue comprises three original studies and five review articles [...]
Tomasz Wilanowski, Sebastian Dworkin
openaire   +2 more sources

transcription-factor-analysis-profacgen.jpg

, 2019
Transcription factors are proteins that bind to specific DNA sequences and regulate the transcription of genetic information from DNA to messenger RNA (mRNA). They are found in all living organisms. https://www.profacgen.com/transcription-factor-analysis.
Jerry Carter (6727871)
core   +1 more source

The Fission Yeast Homeodomain Protein Yox1p Binds to MBF and Confines MBF-Dependent Cell-Cycle Transcription to G1-S via Negative Feedback [PDF]

, 2009
The regulation of the G1- to S-phase transition is critical for cell-cycle progression. This transition is driven by a transient transcriptional wave regulated by transcription factor complexes termed MBF/SBF in yeast and E2F-DP in mammals. Here we apply
Brazma Alvis, Klier, S, Codlin, S, Lackner Daniel H., Bahler, J, Alvis Brazma, Brian T Wilhelm, Robertus A M de Bruin, Sofia Aligianni, de Bruin, RAM, Daniel H Lackner, Sandra Codlin, Gabriella Rustici, Klier Steffi, Wilhelm, BT, Rustici Gabriella, Lackner, DH, Marguerat Samuel, Aligianni, S, Bähler Jürg, de Bruin, RA, Jürg Bähler, Brazma, A, Codlin Sandra, Marguerat, S, Steffi Klier, Wilhelm Brian T., Samuel Marguerat, Aligianni Sofia, de Bruin Robertus A. M., Rustici, G   +30 more
core   +1 more source

The interplay between chromatin and transcription factor networks during B cell development: who pulls the trigger first?

Frontiers in Immunology, 2014
All mature blood cells derive from hematopoietic stem cells (HSCs) through gradual restriction of their cell fate potential and acquisition of specialized functions.
Mohamed-Amin eChoukrallah, Patrick eMatthias   +1 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Metabolic control through the PGC-1 family of transcription coactivators [PDF]

, 2005
Many complex biological programs are controlled at the level of gene transcription by DNA binding transcription factors. Recent studies have revealed a novel mode of regulation by coactivator proteins, best illustrated by the PGC-1 family of coactivators.
Lin, J., Jiandie Lin, Christoph Handschin, Bruce M. Spiegelman, Handschin, C., Spiegelman, B. M.   +5 more
core   +1 more source

Distinct transcriptomic features are associated with transitional and mature B-cell populations in the mouse spleen

Frontiers in Immunology, 2015
Splenic transitional B-cells (T1 and T2) are selected to avoid self-reactivity and to safeguard against autoimmunity, then differentiate into mature follicular (FO-I and FO-II) and marginal zone (MZ) subsets.
Eden eKleiman, Daria eSalyakina, Magali eDe Heusch, Magali eDe Heusch, Kristen L Hoek, Joan M Llanes, Iris eCastro, Jacqueline A Wright, Emily S Clark, Derek Michael Dykxhoorn, Akiko eTakeda, Enrico eCapobianco, Jean-Christophe eRenauld, Jean-Christophe eRenauld, Wasif N Khan   +14 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Variable structure motifs for transcription factor binding sites [PDF]

, 2010
Background: Classically, models of DNA-transcription factor binding sites (TFBSs) have been based on relatively few known instances and have treated them as sites of fixed length using position weight matrices (PWMs).
Evans, Kenneth J., Dyer, N., Nigel Dyer, Ott Sascha, Reid, J.E., Lorenz Wernisch, Sascha Ott, Ott, S., Wernisch Lorenz, John E Reid, Evans Kenneth J, Wernisch, Lorenz, Kenneth J Evans, Dyer Nigel, Reid John E   +14 more
core   +6 more sources

Zygotic pioneer factor activity of Odd-paired/Zic is necessary for late function of the Drosophila segmentation network

eLife, 2020
Because chromatin determines whether information encoded in DNA is accessible to transcription factors, dynamic chromatin states in development may constrain how gene regulatory networks impart embryonic pattern.
Isabella V Soluri, Lauren M Zumerling, Omar A Payan Parra, Eleanor G Clark, Shelby A Blythe   +4 more
doaj   +1 more source