Results 51 to 60 of about 9,355,994 (306)

Sequence Motifs in MADS Transcription Factors Responsible for Specificity and Diversification of Protein-Protein Interaction [PDF]

, 2010
Protein sequences encompass tertiary structures and contain information about specific molecular interactions, which in turn determine biological functions of proteins.
Angenent, G.C., Martijn Fiers, Roeland C H J van Ham, Roeland C. H. J. van Ham, Morabito Giuseppa, Ham, R.C.H.J., van, Aalt D J van Dijk, Angenent Gerco C., Immink, R.G.H., van Dijk, A.D.J., Richard G H Immink, van Dijk Aalt D. J., Morabito, G., van Ham Roeland C. H. J., Dijk, A.D.J., van, Fiers, M.A., Richard G. H. Immink, Giuseppa Morabito, van Ham, R.C.H.J., Aalt D. J. van Dijk, Immink Richard G. H., Gerco C Angenent, Gerco C. Angenent, Fiers Martijn   +23 more
core   +2 more sources

Regulation of breast tumour cell survival by AP-2 transcription factors [PDF]

, 2010
PhDAP-2 transcription factors are crucial regulators of embryonic development and also play important roles in human neoplasia. Over-expression of AP-2α and AP-2γ in primary breast cancer (BC) correlates with expression of two major breast markers ...
Chan, Ka Yi Viona
core   +4 more sources

Distinct transcriptomic features are associated with transitional and mature B-cell populations in the mouse spleen

Frontiers in Immunology, 2015
Splenic transitional B-cells (T1 and T2) are selected to avoid self-reactivity and to safeguard against autoimmunity, then differentiate into mature follicular (FO-I and FO-II) and marginal zone (MZ) subsets.
Eden eKleiman, Daria eSalyakina, Magali eDe Heusch, Magali eDe Heusch, Kristen L Hoek, Joan M Llanes, Iris eCastro, Jacqueline A Wright, Emily S Clark, Derek Michael Dykxhoorn, Akiko eTakeda, Enrico eCapobianco, Jean-Christophe eRenauld, Jean-Christophe eRenauld, Wasif N Khan   +14 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Falling for the dark side of transcription: Nab2 fosters RNA polymerase III transcription. [PDF]

, 2016
RNA polymerase III (RNAPIII) synthesizes diverse, small, non-coding RNAs with many important roles in the cellular metabolism. One of the open questions of RNAPIII transcription is whether and how additional factors are involved.
Reuter, LM, Sträßer, K
core   +1 more source

The interplay between chromatin and transcription factor networks during B cell development: who pulls the trigger first?

Frontiers in Immunology, 2014
All mature blood cells derive from hematopoietic stem cells (HSCs) through gradual restriction of their cell fate potential and acquisition of specialized functions.
Mohamed-Amin eChoukrallah, Patrick eMatthias   +1 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Silodosin inhibits noradrenaline-activated transcription factors Elk1 and SRF in human prostate smooth muscle. [PDF]

, 2012
The transcription factors Elk1 and serum response factor (SRF) are central regulators of cell cycle and phenotype in various cell types. Elk1 is activated by phosphorylation (serine-383), while activation of SRF requires its co-factor, myocardin ...
Christian G Stief, Strittmatter, Frank, Martin Hennenberg, Waidelich, Raphaela, Beckmann, Christer, Füllhase, Claudius, Rutz, Beata, Montorsi, Francesco, Petter Hedlund, Christer Beckmann, Christian Gratzke, Stief, Christian Georg, Raphaela Waidelich, Hedlund, Petter, Frank Strittmatter, Karl-Erik Andersson, Andersson, Karl-Erik, Francesco Montorsi, Hennenberg, Martin, Gratzke, Christian, Beata Rutz, Claudius Füllhase   +21 more
core   +1 more source

Zygotic pioneer factor activity of Odd-paired/Zic is necessary for late function of the Drosophila segmentation network

eLife, 2020
Because chromatin determines whether information encoded in DNA is accessible to transcription factors, dynamic chromatin states in development may constrain how gene regulatory networks impart embryonic pattern.
Isabella V Soluri, Lauren M Zumerling, Omar A Payan Parra, Eleanor G Clark, Shelby A Blythe   +4 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source