Results 151 to 160 of about 4,117,946 (252)

The dynamic pool of Rec8-cohesin is crucial for meiotic recombination and transcription regulation in the yeast Saccharomyces cerevisiae. [PDF]

J Biol Chem
Paliwal S, Dey P, Kumari A, Sadasivam K, Joshi S, Raghuvanshi R, Goyal R, Sanyal K, Nishant KT, Shinohara A, Mehta G.   +10 more
europepmc   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Transcription regulation by TBX18 in smooth muscle cells is essential for normal aortic development and homeostasis. [PDF]

Cardiovasc Res
Mukherjee D, Larcher V, Winter H, Sachs N, Andriani F, Chiesa M, Perrucci GL, Rega S, Günther S, Kuenne C, Martin JC, Gu Y, Pelisek J, Fischer A, Peruzzo S, Pizzo E, Peterson KL, Dimmeler S, Maegdefessel L, Cattaneo P, Evans SM, Guimarães-Camboa N.   +21 more
europepmc   +1 more source

Computational Characterization of Undifferentially Expressed Genes with Altered Transcription Regulation in Lung Cancer. [PDF]

Genes (Basel), 2023
Xin R, Cheng Q, Chi X, Feng X, Zhang H, Wang Y, Duan M, Xie T, Song X, Yu Q, Fan Y, Huang L, Zhou F.   +12 more
europepmc   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Phase-separating fusion proteins drive cancer by upsetting transcription regulation. [PDF]

Genome Biol
Farahi N, Lazar T, Tompa P, Mészáros B, Pancsa R.   +4 more
europepmc   +1 more source

Computational approaches to understand transcription regulation in development. [PDF]

Biochem Soc Trans, 2023
van der Sande M, Frölich S, van Heeringen SJ.   +2 more
europepmc   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Structural basis of transcription regulation in Spirochaeta africana

STRUCTURAL BASIS OF TRANSCRIPTION REGULATION IN SPIROCHAETA AFRICANA Structural basis of transcription regulation in Spirochaeta africana / Wang, Tingting (Rights reserved) (-
Wang, Tingting
core  

Multi-omic relay velocity modeling uncovers dynamic chromatin-transcription regulation across cell states. [PDF]

Nat Commun
Hong A, Lee S, Kim K.
europepmc   +1 more source