Results 161 to 170 of about 4,117,946 (252)

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

CDCA7 targets LSH to DNA maintenance methylation in S phase and transcription regulation in interphase via two distinct DNA-binding modes. [PDF]

Nucleic Acids Res
Chen F, Sun M, Chang M, Dai Z, Chen Z, Li J, Duan Y, Li J, Cao X, Huang Y, Wong J.   +10 more
europepmc   +1 more source

Transcription regulation strategies in methylotrophs: progress and challenges. [PDF]

Bioresour Bioprocess, 2022
Huang X, Song Q, Guo S, Fei Q.
europepmc   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Transcription regulation and human diseases

Swiss Medical Weekly, 2004
Swiss Medical Weekly
doaj   +1 more source

Hallmarks of glucocorticoid receptor condensates involvement in transcription regulation. [PDF]

iScience
Benítez B, Stortz M, De Rossi MC, Presman DM, Levi V.   +4 more
europepmc   +1 more source

Transcription regulation by CarD in mycobacteria is guided by basal promoter kinetics. [PDF]

J Biol Chem, 2023
Zhu DX, Stallings CL.
europepmc   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Electron Paramagnetic Resonance Spectroscopy Reveals Promoter Dependent Transcription Regulation by Copper Activated CueR in Pseudomonas aeruginosa. [PDF]

Chemphyschem
Yasin A, Irshed M, Hofmann L, Shenberger Y, Gevorkyan-Airapetov L, Ruthstein S.   +5 more
europepmc   +1 more source

The Intertwined Role of 8-oxodG and G4 in Transcription Regulation. [PDF]

Int J Mol Sci, 2023
Gorini F, Ambrosio S, Lania L, Majello B, Amente S.   +4 more
europepmc   +1 more source