Results 211 to 220 of about 5,538,535 (384)

A lethal deletion on mouse chromosome 7 affects regulation of liver-cell-specific functions: posttranscriptional control of serum protein and transcriptional control of aldolase B synthesis. [PDF]

, 1985
J M Sala-Trepat, Maryse Poiret, Carole H. Sellem, R. Bessada, T. Erdös, Salome Gluecksohn‐Waelsch   +5 more
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

The Intertwined Role of 8-oxodG and G4 in Transcription Regulation. [PDF]

Int J Mol Sci, 2023
Gorini F, Ambrosio S, Lania L, Majello B, Amente S.   +4 more
europepmc   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Regulation of expression and activity of the yeast transcription factor ADR1. [PDF]

, 1988
Hal Blumberg, Toinette Hartshorne, E T Young   +2 more
openalex   +1 more source

CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes

Cell, 2013
Luke A. Gilbert, Matthew H. Larson, Leonardo Morsut, Zairan Liu, G. Brar, S. E. Torres, Noam Stern-Ginossar, Onn Brandman, E. Whitehead, J. Doudna, W. Lim, J. Weissman, Lei S. Qi   +12 more
semanticscholar   +1 more source

N⁶-methyladenosine in 7SK small nuclear RNA underlies RNA polymerase II transcription regulation. [PDF]

Mol Cell, 2023
Wang Y, Traugot CM, Bubenik JL, Li T, Sheng P, Hiers NM, Fernandez P, Li L, Bian J, Swanson MS, Xie M.   +10 more
europepmc   +1 more source

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source

Multilevel interrogation of H3.3 reveals a primordial role in transcription regulation. [PDF]

Epigenetics Chromatin, 2023
Nabeel-Shah S, Garg J, Ashraf K, Jeyapala R, Lee H, Petrova A, Burns JD, Pu S, Zhang Z, Greenblatt JF, Pearlman RE, Lambert JP, Fillingham J.   +12 more
europepmc   +1 more source

Transcriptional Regulation of Carnitine Palmitoyltransferase Synthesis in Riboflavin Deficiency in Rats

, 1988
Paul S. Brady, Ya-Xiong Feng, Linda J. Brady   +2 more
openalex   +1 more source