Results 151 to 160 of about 8,550,429 (348)

Dysregulation of Positive Transcription Elongation Factor b and Myocardial Hypertrophy [PDF]

Circulation Research, 2009
See related articles, pages 1347–1354 Prolonged stimulus of the adult heart by hypertension, arrhythmias, or other pathogenic conditions can result in myocardial hypertrophy and subsequently heart failure. Hypertrophy is characterized by an increase in the size of cardiomyocytes and this is associated with an elevated rate of RNA synthesis and ...
openaire   +2 more sources

Chemical Screening Identifies Danofloxacin as a Self‐Renewal Agonist of Embryonic Stem Cells through Alleviation of HDAC1‐Mediated Deacetylation of Tert and Prdm10

Advanced Science, EarlyView.
This study identified Danofloxacin as a novel supporter of the maintenance of mouse embryonic stem cell (ESC) pluripotency. It functions partially by inhibiting HDAC1, which increases specific histone acetylation marks and activates key genes like Tert and Prdm10.
Yan Zhang, Junxiang Ji, Baoxing Dong, Zhenhua Zhu, Xucheng Lv, Peng Chen, Wenqiang Liu, Min Zhou, Shou‐Dong Ye   +8 more
wiley   +1 more source

A Pentaradial and Bilateral Combined Photoreception System in the Sea Cucumber is Mediated by a Blue Light‐Sensitive R‐Opsin

Advanced Science, EarlyView.
The sea cucumber Holothuria leucospilota detects blue and adjacent wavelengths of light via an r‐opsin with a maximum absorption at 459 nm. In the oral tentacles, papillae, and tube feet, distinct light‐sensing structures with specialized morphologies are formed, constituting a unique pentaradial and bilateral combined photoreception system.
Jiasheng Huang, Chunhua Ren, Zhou Qin, Yimeng Cui, Bingbing Zhang, Peng Luo, Xuan Wang, Yaoqi Xie, Xin Zhang, Aifen Yan, Yang Zhang, Dingding Fan, Yang Liu, Wenjie Pan, Xiao Jiang, Lihong Yuan, Haipeng Qin, David M. Irwin, Chaoqun Hu, Yang Liu, Ting Chen   +20 more
wiley   +1 more source

RNA interference-mediated co-transcriptional gene silencing in fission yeast [PDF]

, 2012
In the last decade or so, RNA interference (RNAi) has gained unanticipated recognition in the fields of RNA biology and gene regulation. It exists in a wide variety of eukaryotic organisms, and various forms of RNAi are involved in diverse biological ...
Woolcock, Katrina Jane
core   +1 more source

The Protein Phosphatase Inhibitor LB100 Targets the Mesenchymal Lineage of Pancreatic Ductal Adenocarcinoma

MedComm
Pancreatic ductal adenocarcinoma (PDAC) remains a therapeutic challenge, and the aggressive basal‐like/mesenchymal subtype is particularly refractory to chemotherapy, underscoring the need for novel therapies.
Janine Murr, Carolin Schneider, Ningjun Duan, Hazal Köse, Anantharamanan Rajamani, Xueyang He, Jonas Buchloh, Christian Hintze, Atharva Naik, Daniel Goeke, Nicole Rjasanow, Lukas Krauß, Alexandra Nguyen, Sebastian A. Widholz, Christian Schneeweis, Riccardo Trozzo, Felix Orben, Sebastian Mueller, Rupert Öllinger, Juan J Montero, Michael Dudek, Percy Knolle, Bo Kong, Volker Ellenrieder, Constanza Tapia Contreras, Elisabeth Hessmann, Marian Grade, Michael Ghadimi, Christian J. Braun, Roland Rad, Maximillian Reichert, Ulrich Keller, Roland M. Schmid, Paul L. Boutz, Dieter Saur, Matthias Wirth, Oliver H. Krämer, Günter Schneider   +37 more
doaj   +1 more source

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

Transcriptional Blood Signatures Distinguish Pulmonary Tuberculosis, Pulmonary Sarcoidosis, Pneumonias and Lung Cancers [PDF]

, 2013
Rationale New approaches to define factors underlying the immunopathogenesis of pulmonary diseases including sarcoidosis and tuberculosis are needed to develop new treatments and biomarkers. Comparing the blood transcriptional response of tuberculosis
Lipman, M, Derek Blankenship, Katalin A Wilkinson, Christine M Graham, Xu, Zhaohui, Vancheeswaran, Rama, Matthew P. R. Berry (130010), Anne O’Garra (130055), Dominique, Valeyre, Beynon, H, Banchereau, J, Rama Vancheeswaran, Guy Gorochov, Virginia Pascual, Anne O'Garra, Ling-pei Ho, Phillip Vanhems, Damien Chaussabel (26369), Pascual, V, Phillip Vanhems (441320), Xu, Z, Yvonne Kendrick (441315), Kendrick, Yvonne, Rozakeas, F, Chloe I. Bloom (130006), Lipman, Marc, Huw Beynon (441321), Vanhems, Phillip, Fotini Rozakeas, Wickremasinghe, Melissa, Christine M. Graham (130008), Miyara, M, Jacques Banchereau, Wickremasinghe, M, Marc Lipman, Matthew P. R. Berry, Diane Bouvry (441317), Yuanyuan Wang, Huw Beynon, Ferry, T, Berry, MP, Blankenship, D, Derek Blankenship (173502), Wilkinson, Robert J, Gilles Devouassoux (441316), Dominique, V, Ferry, Tristan, Paul S. Redford (441314), Robert J. Wilkinson, Berry, MPR, Matthew P R Berry, Melissa Wickremasinghe, Jacques Banchereau (4187), Wilkinson, Katalin A, Valeyre Dominique, Redford, Paul S, Zhaohui Xu, Saadatian, Mitra, Gilles Devouassoux, Berry, Matthew P R, Wang, Y, O\u27Garra, Anne, Yuanyuan Wang (20181), Rama Vancheeswaran (441322), Blankenship, Derek, Vancheeswaran, R, Katalin A. Wilkinson, Saadatian, M, Mitra Saadatian, Paul S. Redford, O'Garra, A, Chaussabel, Damien, Diane Bouvry, Devouassoux, G, Melissa Wickremasinghe (235318), Ho, LP, Robert J Wilkinson, Ho, Ling-Pei, Mitra Saadatian (441319), Guy Gorochov (89307), Wilkinson, KA, Pascual, Virginia, Rozakeas, Fotini, Katalin A. Wilkinson (130012), Robert J. Wilkinson (130050), Zhaohui Xu (130026), Damien Chaussabel, Gorochov, Guy, Graham, CM, Beynon, Huw, Valeyre, D, Tristan Ferry, Tristan Ferry (412308), Redford, PS, Bloom, Chloe I, Virginia Pascual (130037), Bouvry, D, Chaussabel, D, Chloe I. Bloom, Marc Lipman (130043), Vanhems, P, Bloom, CI, Paul S Redford, Chloe I Bloom, Ling-pei Ho (5655859), Wang, Yuanyuan, Yvonne Kendrick, Anne O’Garra, Dominique Valeyre, Gorochov, G, Kendrick, Y, Makoto Miyara, Bouvry, Diane, Banchereau, Jacques, Miyara, Makoto, Valeyre Dominique (441318), Christine M. Graham, Devouassoux, Gilles, Ho, L-P, Wilkinson, RJ, Makoto Miyara (199979), Graham, Christine M, Fotini Rozakeas (130019)   +122 more
core   +1 more source

Knockdown of selenocysteine-specific elongation factor in Amblyomma maculatum alters the pathogen burden of Rickettsia parkeri with epigenetic control by the Sin3 histone deacetylase corepressor complex.

PLoS ONE, 2013
Selenocysteine is the 21st naturally-occurring amino acid. Selenoproteins have diverse functions and many remain uncharacterized, but they are typically associated with antioxidant activity.
Steven W Adamson, Rebecca E Browning, Khemraj Budachetri, José M C Ribeiro, Shahid Karim   +4 more
doaj   +1 more source

Pre‐Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair

Advanced Science, EarlyView.
The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang, Qiang Chen, Aihua Jin, Xiaoqi Yang, Hui Zhou, Weiquan Gong, Jin Cheng, Jun Dai, Minjin Wang, Meihua Piao, Yuanyi Wang, Nan Zhou   +11 more
wiley   +1 more source

Tat gets the "green" light on transcription initiation

Retrovirology, 2005
Human immunodeficiency virus type 1 (HIV-1) Tat transactivation is an essential step in the viral life cycle. Over the past several years, it has become widely accepted that Tat exerts its transcriptional effect by binding the transactivation-responsive ...
Kashanchi Fatah, Brady John
doaj   +1 more source