Results 141 to 150 of about 8,550,429 (348)

Bottom‐Up Engineering of a Human Neuromuscular System for Modeling Activity‐Induced Remodeling, Metabolic Stress, and Endothelial‐Modulated Excitability

Advanced Materials, EarlyView.
Using a bottom‐up approach, we engineered a human neuromuscular microchip to investigate distinct adaptive responses to neural stimulation and metabolic stress. Further integration of endothelial cells revealed their critical role in modulating neuromuscular excitability, establishing a comprehensive neurovascular‐muscular model.
Jinchul Ahn, Min‐seop Kim, Ju‐Hee Kim, Seok‐Hyeon Kang, Dain Lee, Hui‐Wen Liu, Seung‐cheol Shin, Kyuhwan Na, Yesl Jun, Oak‐Kee Hong, Ji Hun Yang, Jin‐A Kim, Hwanseok Jang, Hong Nam Kim, Roger D. Kamm, Ji‐Hoon Kim, Jang‐Won Son, Seok Chung   +17 more
wiley   +1 more source

Drosophila HP1c is regulated by an auto-regulatory feedback loop through its binding partner Woc [PDF]

, 2009
HP1 is a major component of chromatin and regulates gene expression through its binding to methylated histone H3. Most eukaryotes express at least three isoforms of HP1 with similar domain architecture.
Eskeland, Ragnhild, RAFFA, GRAZIA DANIELA, Eskeland Ragnhild, Abel, Jochen, Jochen Abel, Raffa Grazia D., Raffa, Grazia D, Ragnhild Eskeland, Abel Jochen, Kremmer Elisabeth, Abel, J., Imhof Axel, Raffa, G.D., Ragnhild Eskel, Imhof, Axel, Eskeland, R., Grazia D. Raffa, Kremmer, E., Imhof, A., Kremmer, Elisabeth, Axel Imhof, Grazia D Raffa, Elisabeth Kremmer   +22 more
core   +1 more source

Novel domains and orthologues of eukaryotic transcription elongation factors

Nucleic Acids Research, 2002
The passage of RNA polymerase II across eukaryotic genes is impeded by the nucleosome, an octamer of histones H2A, H2B, H3 and H4 dimers. More than a dozen factors in the yeast Saccharomyces cerevisiae are known to facilitate transcription elongation through chromatin.
openaire   +4 more sources

Transcription Elongation Factor GreA Has Functional Chaperone Activity

PLoS ONE, 2012
Bacterial GreA is an indispensable factor in the RNA polymerase elongation complex. It plays multiple roles in transcriptional elongation, and may be implicated in resistance to various stresses.In this study, we show that Escherichia coli GreA inhibits aggregation of several substrate proteins under heat shock condition.
Kun Li, Tianyi Jiang, Bo Yu, Limin Wang, Chao Gao, Cuiqing Ma, Ping Xu, Yanhe Ma   +7 more
openaire   +4 more sources

Iterative Selection of DNA Nanostructures for Cellular Uptake

Advanced Materials, EarlyView.
DNA nanostructures are promising cell targeting delivery vehicles for therapeutics, but the targeting behavior is not fully understood. In this study, libraries of DNA nanostructures that can be amplified and sequenced are combined with cellular uptake as a selection pressure to iteratively refine DNA structures taken up in cells to better understand ...
Anjali Rajwar, Lisa Eichhorn, Jakub Palacka, Sandra Ly, Erik Benson   +4 more
wiley   +1 more source

elongation

, 2016
elongation.csv - 'Plot_nr' shows plot number - 'Plot' shows treatment, 'contr' = control, 'new' = short-term manipulation (1 yr), 'old' = long-term manipulation (11 yrs) - 'individual' shoot elongation (growth) is measured on 5 individuals per plot ...
Hjalmar Laudon (1297494), Gesche Blume-Werry (3322224), Juergen Kreyling (3322227), Kreyling, Juergen, Laudon, Hjalmar, Ann Milbau (527594), Milbau, Ann, Blume-Werry, Gesche   +7 more
core   +1 more source

The RhoA transcriptional program in pre-T cells [PDF]

, 2007
The GTPase RhoA is essential for the development of pre-T cells in the thymus. To investigate the mechanisms used by RhoA to control thymocyte development we have used Affymetrix gene profiling to identify RhoA regulated genes in T cell progenitors.
Lightfoot, K., Cantrell, D., Miller, M., Lahesmaa, R., Clarke, R., Mullin, M.   +5 more
core   +1 more source

Fabrication of Aligned Polycaprolactone Nanofibrillar Bundles to Control Cell‐Mediated Collagen Deposition in Engineered Cartilage

Advanced Materials, EarlyView.
Melt electrofibrillation (MEF) enables the fabrication of nanofibrillar PCL scaffolds with defined architectures that guide cellular alignment and retention during cartilage tissue engineering. Unlike conventional melt electrowriting, MEF consistently directs collagen type II‐rich extracellular matrix organization, providing a tunable platform to ...
Alba Pueyo Moliner, Lennard Spauwen, James L. Martin Robinson, Ángela García Grech, Isabelle Martinier, Sara Grasselli, Aylin Kara Özenler, Matthias Ryma, Jürgen Groll, Mylène de Ruijter, Jos Malda   +10 more
wiley   +1 more source

Structure of a transcribing Pol II-DSIF-SPT6-U1 snRNP complex

Nature Communications
In eukaryotic cells, splicing occurs predominantly co-transcriptionally, enhancing splicing efficiency and fidelity while introducing an additional layer of regulation over gene expression.
Luojia Zhang, Christopher Batters, Shintaro Aibara, Yuliya Gordiyenko, Kristina Žumer, Jana Schmitzová, Kerstin Maier, Patrick Cramer, Suyang Zhang   +8 more
doaj   +1 more source

Transcription-driven chromatin repression of Intragenic transcription start sites.

PLoS Genetics, 2019
Progression of RNA polymerase II (RNAPII) transcription relies on the appropriately positioned activities of elongation factors. The resulting profile of factors and chromatin signatures along transcription units provides a "positional information system"
Mathias Nielsen, Ryan Ard, Xueyuan Leng, Maxim Ivanov, Peter Kindgren, Vicent Pelechano, Sebastian Marquardt   +6 more
doaj   +1 more source