Results 121 to 130 of about 8,550,429 (348)

The in vivo dynamics of TCERG1, a factor that couples transcriptional elongation with splicing [PDF]

RNA, 2016
Coupling between transcription and RNA processing is key for gene regulation. Using live-cell photobleaching techniques, we investigated the factor TCERG1, which coordinates transcriptional elongation with splicing. We demonstrate that TCERG1 is highly mobile in the nucleoplasm and that this mobility is slightly decreased when it is associated with ...
Sánchez-Hernández, Noemí, Boireau, Stéphanie, Schmidt, Ute, Muñoz-Cobo, Juan Pablo, Hernández-Munain, Cristina, Bertrand, Edouard, Suñé, Carlos   +6 more
openaire   +3 more sources

A Magneto‐Mechanically Activated Nerve Guidance Conduit Promotes Peripheral Nerve Regeneration via TIMP1‐Mediated Membrane Tension Transfer

Advanced Functional Materials, EarlyView.
This study presents a magneto‐mechanical strategy that incorporates FP@MSCs into an aligned PCL/GelMA nerve guidance conduit. Magnetic stimulation increases membrane tension in FP@MSCs, triggering cytoskeletal remodeling, Schwann cell‐like differentiation, and TIMP1 secretion. TIMP1 activates ITGB1/CD63–FAK signaling in NE‐4C cells, increasing membrane
Xinyu Zhu, Yumin Wu, Xiang Gao, Tianlu Wang, Wanting Jia, Xueying Mei, Huanzhong Ji, Zongxi Wu, Yujie Liang, Xiang Li, Kan Li, Jingyuan Li, Guangsen Zheng, Guiqing Liao, Siyong Gao   +14 more
wiley   +1 more source

A Comprehensive, Quantitative, and Genome-Wide Model of Translation [PDF]

, 2010
Translation is still poorly characterised at the level of individual proteins and its role in regulation of gene expression has been constantly underestimated.
Piotr Zielenkiewicz, Siwiak, Marlena, Marlena Siwiak, Zielenkiewicz, Piotr   +3 more
core   +1 more source

Isoginkgetin and Madrasin are poor splicing inhibitors.

PLoS ONE
The production of eukaryotic mRNAs requires transcription by RNA polymerase (pol) II and co-transcriptional processing, including capping, splicing, and cleavage and polyadenylation.
Michael Tellier, Gilbert Ansa, Shona Murphy   +2 more
doaj   +1 more source

A role for Chk1 in blocking transcriptional elongation of p21 RNA during the S-phase checkpoint.

Genes & Development, 2009
We reported previously that when cells are arrested in S phase, a subset of p53 target genes fails to be strongly induced despite the presence of high levels of p53.
R. Beckerman, A. J. Donner, M. Mattia, M. Peart, J. Manley, Joaquín M. Espinosa, C. Prives   +6 more
semanticscholar   +1 more source

Genome-wide kinetic properties of transcriptional bursting in mouse embryonic stem cells

Science Advances, 2020
The kinetic properties of transcriptional bursting were comprehensively analyzed in mouse embryonic stem cells. Transcriptional bursting is the stochastic activation and inactivation of promoters, contributing to cell-to-cell heterogeneity in gene ...
H. Ochiai, T. Hayashi, Mana Umeda, M. Yoshimura, Akihito Harada, Yukiko Shimizu, Kenta Nakano, N. Saitoh, Zhe J. Liu, Takashi Yamamoto, T. Okamura, Y. Ohkawa, H. Kimura, I. Nikaido   +13 more
semanticscholar   +1 more source

Transcription Elongation Factors Are Potential Targets in Glioblastoma [PDF]

Cancer Discovery, 2017
Abstract JMJD6 promotes transcription pause-release and elongation and glioblastoma cell survival in vivo.
openaire   +1 more source

Patient‐Derived 3D Heart‐On‐a‐Chip Model of Dilated Cardiomyopathy With Embedded Bead‐Based Mapping of Tissue Contractility

Advanced Healthcare Materials, EarlyView.
A heart‐on‐a‐chip model of dilated cardiomyopathy is developed from patient‐derived induced pluripotent stem cells. The model recapitulates key disease phenotypes and enables functional assessment through integrated bead‐based tracking and pillar deflection measurements.
Ali Mousavi, Ludovic Mouttet, Shihao Cui, Yasaman Hekmatnia, Mehran Mottahedi, Ida Derish, Naimeh Rafatian, Mark Aurousseau, Gregor Andelfinger, Renzo Cecere, Houman Savoji   +10 more
wiley   +1 more source

Reliable transfer of transcriptional gene regulatory networks between taxonomically related organisms [PDF]

, 2009
Baumbach J, Rahmann S, Tauch A. Reliable transfer of transcriptional gene regulatory networks between taxonomically related organisms. BMC Systems Biology.
Sven Rahmann, Andreas Tauch, Tauch, Andreas, Baumbach, Jan, Jan Baumbach, Rahmann, Sven   +5 more
core   +1 more source

Tumor suppressor p53: a transcription elongation factor

The FASEB Journal, 2007
Sequence‐specific transcriptional activators are normally thought to function by stably binding to their cognate DNA sequences, followed by recruitment of nucleosome remodeling complexes and components of the general transcription machinery to the promoter regions of target genes.
Sri Kripa Balakrishnan, David S. Gross
openaire   +1 more source