Results 111 to 120 of about 8,550,429 (348)

Vps Factors Are Required for Efficient Transcription Elongation in Budding Yeast [PDF]

Genetics, 2013
Abstract There is increasing evidence that certain Vacuolar protein sorting (Vps) proteins, factors that mediate vesicular protein trafficking, have additional roles in regulating transcription factors at the endosome. We found that yeast mutants lacking the phosphatidylinositol 3-phosphate [PI(3)P] kinase Vps34 or its associated protein
Wong, CM, Malcova, I, Vasicova, P, Brickner, JH, Hinnebusch, AG, Gaur, NA, Hasek, J, Brickner, DG, Qiu, H, Zhang, F   +9 more
openaire   +4 more sources

Wearable Smart Patches on Sustainable Chitosan With Reversible Microbial Growth‐Inhibitory Properties

Advanced Functional Materials, EarlyView.
ABSTRACT Chitosan, a polysaccharide upcycled from biowaste, has long promised sustainable, biocompatible, and antimicrobial films and devices, an appeal reinforced by its recent regulatory recognition, with several chitosan‐based antibacterial dressings gaining clearance through the Food and Drug Administration's 510(k) pathway.
Jacopo Nicoletti, Kubra Kocak, Andrea Michel, Enrico Cavarzerani, Ali Raza, Petr Rohzin, Nouha Loudhaief, Saimir Frroku, Nicolò Baldovin, Hazrat Bilal, Alvise Perosa, Maurizio Selva, Flavio Rizzolio, Luca Sbuelz, Sabrina Tamburini, Domenico De Fazio, Giovanni Antonio Salvatore   +16 more
wiley   +1 more source

The HY5-PIF regulatory module coordinates light and temperature control of photosynthetic gene transcription [PDF]

, 2014
The ability to interpret daily and seasonal alterations in light and temperature signals is essential for plant survival. This is particularly important during seedling establishment when the phytochrome photoreceptors activate photosynthetic pigment ...
Stewart, Kelly L., Karen J. Halliday (561241), Toledo Ortiz, Gabriela, Stewart, Kelly, Bou Torrent, Jordi, Keun Pyo Lee (577334), Gabriela Toledo-Ortiz, Lee, Keun Pyo, Gavin Steel, Karen J Halliday, Steel, Gavin, Keun Pyo Lee, Jordi Bou-Torrent (204117), Gavin Steel (577336), Toledo-Ortiz, Gabriela, Rodríguez-Concepción, Manuel, Manuel Rodríguez-Concepción (2185861), Jordi Bou-Torrent, Kelly Stewart, Henrik Johansson (519182), Halliday, Karen J., Henrik Johansson, Halliday, Karen J, Manuel Rodríguez-Concepción, Johansson, Henrik, Bou-Torrent, Jordi, Karen J. Halliday, Gabriela Toledo-Ortiz (577333), Rodríguez Concepción, Manuel, Kelly Stewart (577335)   +29 more
core   +1 more source

Making a Short Story Long: Regulation of P-TEFb and HIV-1 Transcriptional Elongation in CD4+ T Lymphocytes and Macrophages

Biology, 2012
Productive transcription of the integrated HIV-1 provirus is restricted by cellular factors that inhibit RNA polymerase II elongation. The viral Tat protein overcomes this by recruiting a general elongation factor, P-TEFb, to the TAR RNA element that ...
Andrew P. Rice, Hart Donahue, Sona Budhiraja, Hongbing Liu, Rajesh Ramakrishnan, Karen Chiang   +5 more
doaj   +1 more source

The transcription elongation factor TCEA3 promotes the activity of the myogenic regulatory factors

PLOS ONE, 2019
The transcription elongation factor TFIIS is encoded by a three member gene family in vertebrates. Here we show that one member of this family, TCEA3, is upregulated during skeletal muscle differentiation and acts to promote gene activation by the myogenic regulatory family of transcription factors, which includes MyoD and myogenin.
Noor Kazim, Abhinav Adhikari, Judith Davie   +2 more
openaire   +4 more sources

The splicing factor SC35 has an active role in transcriptional elongation [PDF]

Nature Structural & Molecular Biology, 2008
Mounting evidence suggests that transcription and RNA processing are intimately coupled in vivo, although each process can occur independently in vitro. It is generally thought that polymerase II (Pol II) C-terminal domain (CTD) kinases are recruited near the transcription start site to overcome initial Pol II pausing events, and that stably bound ...
Lin, Shengrong, Coutinho-Mansfield, Gabriela, Wang, Dong, Pandit, Shatakshi, Fu, Xiang-Dong   +4 more
openaire   +2 more sources

3D Bioprinted Glioblastoma Multiforme Models: How the Extracellular Matrix Glycosignature Influences Drug Response

Advanced Functional Materials, EarlyView.
Aberrant glycosylation in the glioblastoma tumor microenvironment drives therapeutic resistance. Here, a 3D bioprinted model was engineered by incorporating α‐NeuNAc‐(2→3)‐β‐D‐Gal‐ and chondroitin sulfate. Combined multiplex immunofluorescence and synchrotron‐based nanoCT analysis revealed that glycan‐matrix interactions dictate specific drug‐escape ...
Francesca Cadamuro, Marco Piazzoni, Ilaria Borghi, Alberto Baeri, Alessandro Fumagalli, Federica Perillo, Hafiz Muhammad Fahad, Martina Ghizzi, Luca Crippa, Gabriella Nicolini, Angela Bentivegna, Daniele Ramazzotti, Valentina Zuliani, Mirko Rivara, Carlo Giorgio Giussani, Andrea Di Cristofori, Guido Cavaletti, Federica Facciotti, Sobhan Sheikhi, Claire Seydoux, Murielle Salome, Peter Cloetens, Alberto Bravin, Paola Coan, Francesco Nicotra, Laura Russo   +25 more
wiley   +1 more source

Identification of autophosphorylation sites in eukaryotic elongation factor-2 kinase [PDF]

, 2012
eEF2K [eEF2 (eukaryotic elongation factor 2) kinase] phosphorylates and inactivates the translation elongation factor eEF2. eEF2K is not a member of the main eukaryotic protein kinase superfamily, but instead belongs to a small group of so-called ...
Hussain, Nusrat, Proud, Christopher G, Proud, C., Wang, Xuemin, Rider, M., Rider, Mark H, Pyr Dit Ruys, S., Vertommen, D., Rider, Mark, Pyr Dit Ruys, Sébastien, Herinckx, Gaëtan, Vertommen, Didier, Herinckx, G., Smith, Ewan M, Wang, X., Smith, E., Hussain, N.   +16 more
core   +1 more source

RBM22 regulates RNA polymerase II 5′ pausing, elongation rate, and termination by coordinating 7SK-P-TEFb complex and SPT5

Genome Biology
Background Splicing factors are vital for the regulation of RNA splicing, but some have also been implicated in regulating transcription. The underlying molecular mechanisms of their involvement in transcriptional processes remain poorly understood ...
Xian Du, Wenying Qin, Chunyu Yang, Lin Dai, Mingkui San, Yingdan Xia, Siyu Zhou, Mengyang Wang, Shuang Wu, Shaorui Zhang, Huiting Zhou, Fangshu Li, Fang He, Jingfeng Tang, Jia-Yu Chen, Yu Zhou, Rui Xiao   +16 more
doaj   +1 more source

Multivalent Role of Human TFIID in Recruiting Elongation Components at the Promoter-Proximal Region for Transcriptional Control

Cell Reports, 2019
Summary: Despite substantial progress in our understanding of the players involved and the regulatory mechanisms controlling the initiation and elongation steps of transcription, little is known about the recruitment of elongation factors at promoter ...
Dipika Yadav, Koushik Ghosh, Subham Basu, Robert G. Roeder, Debabrata Biswas   +4 more
doaj   +1 more source