Results 221 to 230 of about 8,550,429 (348)

Control of transcriptional elongation and cotranscriptional histone modification by the yeast BUR kinase substrate Spt5

Proceedings of the National Academy of Sciences of the United States of America, 2009
Karen Zhou, W. Kuo, Jeffrey Fillingham, J. Greenblatt   +3 more
semanticscholar   +1 more source

EBV‐Driven ODC1 Upregulation Enhances Polyamine Anabolism to Promote Viral Replication and Cisplatin Resistance in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
EBV‑BZLF1 initiates ODC1‑driven polyamine anabolism that correlates with poor clinical prognosis in nasopharyngeal carcinoma. The ODC1–spermidine axis promotes viral replication, cell proliferation and innate immune evasion. Pharmacological inhibition of ODC1 rescues cisplatin sensitivity, establishing ODC1 as a viable therapeutic target for EBV ...
Yueshuo Li, Xudong Hu, Chenxing Yang, Na Liu, Lin Wang, Xi Cai, Min Tang, Ya Cao, Li Shang, Feng Shi   +9 more
wiley   +1 more source

RNA polymerase II phosphorylation dynamics: from molecular mechanisms to human disease. [PDF]

RNA Biol
González-Jiménez A, Medina I, Alfonso MJ, Vázquez de Aldana CR, Calvo O.   +4 more
europepmc   +1 more source

Herbivory‐Induced Stomatal Opening Triggers the Dispersal of an Invasive Insect Herbivore

Advanced Science, EarlyView.
The invasive leafminer Phthorimaea absoluta uniquely manipulates plant defenses by inducing stomatal opening in tomato. This response, mediated by the stomatal regulator IQM1, enhances the release of the repellent volatile benzaldehyde. This volatile triggers the dispersal of adult moths, facilitates colonization of new hosts, and leads to rapid ...
Limin Chen, Xiaowei Li, Yaru Wang, Farman Ullah, Shuxing Zhou, Lemeng Dong, Weizhong He, Harro J. Bouwmeester, Youming Hou, Ian T. Baldwin, Yaobin Lu   +10 more
wiley   +1 more source

Integrated signaling mechanisms governing root hair growth via transcriptional master regulators. [PDF]

Plant J
Hipperdinger YG, Gonzalez NA, Padilla G, Estevez JM.   +3 more
europepmc   +1 more source

Klotho‐Derived Peptide 1 Protects against Acute Kidney Injury by Directly Targeting Mitochondrial ATAD3A

Advanced Science, EarlyView.
This study uncovers that KP1, a Klotho‐derived peptide, protects the kidney against acute kidney injury, a clinical syndrome with high morbidity and mortality. KP1 enters tubular epithelial cells via endocytosis, directly interacts with the mitochondrial ATAD3A/HIGD2A complex, thereby preventing cytochrome c release, and caspases activation, and ...
Xiaoyao Zhang, Shihui Lin, Tianyu Wu, Zhixin Zhang, Hong Zhou, Xue Hong, Youhua Liu   +6 more
wiley   +1 more source

Oxidative stress triggers RNAPII arrest through PARylation and DNA damage. [PDF]

Nat Commun
Thomas QA, Wu L, Lesage E, Iversen HKM, López Martínez D, Kompocholi S, Liu H, Nieto Moreno N, Gregersen LH.   +8 more
europepmc   +1 more source

The stress-activated Hog1 kinase is a selective transcriptional elongation factor for genes responding to osmotic stress.

Molecules and Cells, 2006
M. Proft, Glòria Mas, Eulàlia de Nadal, A. Vendrell, N. Noriega, K. Struhl, F. Posas   +6 more
semanticscholar   +1 more source

Selective Modulation of OTUB1 Noncanonical Function via a bioPhosTAC Strategy

Advanced Science, EarlyView.
This work positions the versatile performance of the peptide‐based bioPhosTAC platform for dissecting phosphorylation‐dependent biology and expanding the scope of induced‐proximity technologies. We demonstrated that selective manipulation of a tyrosine phosphorylation site is sufficient to propagate coordinated cellular consequences.
Seung Un Seo, Seon Min Woo, Minhyeong Choi, Soeun Rhee, Simmyung Yook, Donghyuk Shin, Kwang‐Su Park, Taeg Kyu Kwon   +7 more
wiley   +1 more source

Targeting super elongation complex-driven RNA polymerase II elongation reduces plaque vulnerability. [PDF]

Signal Transduct Target Ther
Kokot KE, Reichardt S, Menedo C, Erbe S, Kneuer JM, Palm KCA, Hoba J, Andritschke M, Katzmann M, Reuser A, von Scheidt M, Mokry M, Xiao J, Sheikh BN, Klöting N, Laufs U, Boeckel JN.   +16 more
europepmc   +1 more source