Results 231 to 240 of about 104,900 (265)
Some of the next articles are maybe not open access.
Stimulatory effect of splicing factors on transcriptional elongation
Nature, 2001Transcription and pre-mRNA splicing are tightly coupled gene expression events in eukaryotic cells. An interaction between the carboxy-terminal domain of the largest subunit of RNA polymerase (Pol) II and components of the splicing machinery is postulated to mediate this coupling.
Y W, Fong, Q, Zhou
openaire +2 more sources
Promoting elongation with transcript cleavage stimulatory factors
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 2002Transcript elongation by RNA polymerase is a dynamic process, capable of responding to a number of intrinsic and extrinsic signals. A number of elongation factors have been identified that enhance the rate or efficiency of transcription. One such class of factors facilitates RNA polymerase transcription through blocks to elongation by stimulating the ...
Rachel N, Fish, Caroline M, Kane
openaire +2 more sources
Transcript elongation factors: shaping transcriptomes after transcript initiation
Trends in Plant Science, 2014Elongation is a dynamic and highly regulated step of eukaryotic gene transcription. A variety of transcript elongation factors (TEFs), including modulators of RNA polymerase II (RNAPII) activity, histone chaperones, and histone modifiers, have been characterized from plants.
Mieke, Van Lijsebettens +1 more
openaire +2 more sources
Mechanisms of Transcription Elongation Factor DSIF (Spt4–Spt5)
Journal of Molecular Biology, 2021The transcription elongation factor Spt5 is conserved from bacteria to humans. In eukaryotes, Spt5 forms a complex with Spt4 and regulates processive transcription elongation. Recent studies on transcription elongation suggest different mechanistic roles in yeast versus mammals.
openaire +2 more sources
Transcription Elongation Factors Repress Transcription Initiation from Cryptic Sites
Science, 2003Previous studies have suggested that transcription elongation results in changes in chromatin structure. Here we present studies of Saccharomyces cerevisiae Spt6, a conserved protein implicated in both transcription elongation and chromatin structure. Our results show that, surprisingly, an
Craig D, Kaplan +2 more
openaire +2 more sources
Cellular dynamics of the negative transcription elongation factor NELF
Experimental Cell Research, 2009Negative Elongation Factor (NELF) is a transcription factor discovered based on its biochemical activity to suppress transcription elongation, and has since been implicated in various diseases ranging from neurological disorders to cancer. Besides its role in promoter-proximal pausing of RNA polymerase II during early stages of transcription, recently ...
Tetsu M C, Yung +4 more
openaire +2 more sources
Transcript Elongation Factor TFIIS Is Involved in Arabidopsis Seed Dormancy
Journal of Molecular Biology, 2009Transcript elongation factor TFIIS promotes efficient transcription by RNA polymerase II, since it assists in bypassing blocks during mRNA synthesis. While yeast cells lacking TFIIS are viable, inactivation of mouse TFIIS causes embryonic lethality. Here, we have identified a protein encoded in the Arabidopsis genome that displays a marked sequence ...
Grasser, Marion +5 more
openaire +4 more sources
Transcription elongation factor S-II is not required for transcription-coupled repair in yeast
Molecular and General Genetics MGG, 1997Two different subpathways play a role in removal of UV-induced cyclobutane pyrimidine dimers (CPDs) by nucleotide excision repair (NER). The relatively slow global genome repair subpathway operates on all CPDs irrespective of their position in the DNA, whereas the transcription-coupled repair subpathway is responsible for the rapid removal of CPDs from
R A, Verhage +3 more
openaire +2 more sources
Characterization of the gene encoding the human transcriptional elongation factor TFIIS
Gene, 1994The transcriptional elongation factor TFIIS causes stimulation of RNA polymerase II elongation and readthrough of some of the elongation blocks. We present cloning and sequence characterization of the human TFIIS gene and a pseudogene. The intron-less organization of both of these genes indicates that previously identified cDNAs which suggested the ...
PARK, HR +4 more
openaire +3 more sources